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| 1 | Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis显示文摘AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP).Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation.METHODS: AP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were done.RESULTS: Histopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for NO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and NO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas NO.CONCLUSION: NO increases in both pancreas and lungs in AP and NO contributes to the pathogenesis of AP under oxidative stress. | Gülnur Andican Remisa Gelisgen Ethem Unal Osman Baran Tortum Sergülen Dervisoglu Tayfun Karahasanoglu Gülden Bur(?)ak | 2005 | World Journal of Gastroenterology2005，11，15： | 18 |
| 2 | Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus 显示文摘 | Tabak O Gelisgen R Erman H | 2011 | Clin Invest Med2011，34，3： | 1 |
| 3 | Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus 显示文摘 | Tabak O Gelisgen R Erman H | 2011 | Clin Invest Med2011，34，3： | 1 |
| 4 | Oxidative lipid,protein,and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus显示文摘 | Tabak O Gelisgen R Erman H | | 0，，03： | 1 |
| 5 | Oxidative lipid,protein,andDNA damage as oxidative stress markers in vascular complications ofdiabetes mellitus显示文摘 | Tabak O Gelisgen R Erman H | 2011 | Clin Invest Med2011，34，3： | 1 |
| 6 | The effects of 1713- estradiol plus drospirenone on anthropometric and biochemical measures of adiposity in menopausal women显示文摘 | Karakus M Gelisgen R Topcuoglu A | 2012 | Arch Gynecol Obstet2012，286，5： | 1 |
| 7 | Hypertension and hemostatic/fibrinolytic balance disorders显示文摘 | Tabak O Gelisgen R Uzun H | 2009 | Clin Invest Med2009，32，6： | 1 |
| 8 | Circulating levels of adiponectin, orexin-A, ghrelin and the antioxidant paraoxonase-I in metabolic syndrome 显示文摘 | TABAK O GELISGEN R CICEKCI H | 2012 | Minerva Med2012，103，4： | 1 |
| 9 | The effects of 17βestradiol plus drospirenone on anthropometric and biochemical measures of adiposity in menopausal women显示文摘 | Karakus M Gelisgen R Topcuoglu A | 2012 | Arch Gynecol Obstet2012，286，5： | 1 |
| 10 | Hypertension and hemostatic/fi- brinolytic balance disorders 显示文摘 | Tabak O Gelisgen R Uzun H | 2009 | Clin Invest Med2009，32，6： | 1 |
| 11 | Hypertension and hemostatic/fibrinolytic balance disorders显示文摘 | Tabak 0 Gelisgen R Uzun H | 2009 | Clin Invest Med2009，32，6： | 1 |
| 12 | Oxidative lipid, pro- tein, and DNA damage as oxidative stress markers in vascular com- plications of diabetes mellitus 显示文摘 | TABAK O GELISGEN R ERMAN H | 2011 | Clin Invest Med2011，34，3： | 1 |
| 13 | Oxidative lipid, protein and DNA damageas oxidative stress markers in vascular complications of diabetes mellitus 显示文摘 | Tabak O Gelisgen R Erman H | 2011 | Clin Invest Med2011，34，3： | 1 |
| 14 | Comparison of maternal and umbilical cord blood soluble lectin-like oxidized low-density lipoprotein receptor 1 levels in early- and late-onset preeclampsia显示文摘 | A. Tuten H. Erman G. G. Korkmaz M. Oncul R. Gelisgen V. Sozer S. Ac?kgoz G. Simsek H. Uzun | 2014 | Archives of Gynecology and Obstetrics2014，，5： | 1 |
| 15 | And DNA damage as oxidative stress markers in vascular complications of diabetes mellitus 显示文摘 | TABAK O GELISGEN R ERMAN H L | 2011 | Clinical and Investigative Medicine2011，34，3： | 1 |
| 16 | Oxidative lipid,protein,and DNA damage as oxidative stress markersin vascular complications of diabetes mellitus显示文摘 | Tabak O Gelisgen R Erman H | 2011 | Clin Invest Med2011，34，3： | 1 |
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