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| 1 | Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner显示文摘Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after receiving intravenous injection of recombinant murine CIRP (rmCIRP, 5 mg/kg body weight (BW)) or PBS (vehicle), those mice receiving rmCIRP showed significantly increased expression of CD69 and CD25 on both CD4+ and CD8+ splenic T cells. This effect, however, was not seen in TLR4-deficient mice after rmCIRP injection. In addition, treatment with CIRP predisposed CD4+ T cells to a Th1 hyperinflammatory response profile, and influenced CD8+ T cells toward a cytotoxic profile. Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner. | Alexandra C Bolognese Archna Sharma Weng-Lang Yang Jeffrey Nicastro Gene F Coppa Ping Wang | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 2 | Cadmium toxicity among wildlife in the Colorado Rocky Mountaion显示文摘 | James R L Gene E L John W F | | 0，，13： | 1 |
| 3 | Bioehem Biophys Res Commun显示文摘 | Gao F Zhao ZL Zhao WT miR-9 modulates the expression of in- terferon-regulated genes and MHC class I molecules in human na- sopharyngeal carcinoma cells | 2013 | 431(3) :6102013，431，3： | 1 |
| 4 | Guidelines for the prevention of falls in people over 65显示文摘 | Gene F Colin C Sheila D | 2000 | BMJ2000，321，7267： | 1 |
| 5 | Tn-AT1,by cDNA microarray显示文摘 | KAWAMATA H FURIHATA T OMOTEHARA F Identification of genes differentially expressed in a newly isolated human metastasizing esophageal cancer cell line T | 2003 | Cancer Sci2003，94，8： | 1 |
| 6 | N16-5显示文摘 | Ma Y H Xue Y F Dou Y T et ah Characterization and gene cloning of a novel fl mannanase from alkaliphilic Bacillus sp | 2004 | Extremophiles2004，8，： | 1 |
| 7 | Application of recursive partitioning analysis and evaluation of the use of whole brain radiation among patients treated with stereotactic radiosurgery for newly diagnosed brain metastases显示文摘 | Mark A Chidel John H Suh Chandana A Reddy Sam T Chao Melissa F Lundbeck Gene H Barnett | 2000 | International Journal of Radiation Oncology Biology Physics2000，，4： | 1 |
| 8 | Rheology of high internal phase emulsions显示文摘 | Cynthia F Welch Gene D | 2006 | Langmuir2006，22，： | 1 |
| 9 | Cardiovascular prognosis of 'masked hypertension' detected by blood pressure self-measurement in elderly treated hypertensive patients 显示文摘 | Bobrie G Chatellier F Genes N | 2004 | JAMA2004，291，11： | 1 |
| 10 | sp Vasinfectum显示文摘 | DOWD C Wilson L W McFadden H Gene expression profile changes in cotton root and hypocotyl tissues in response to in- fection with Fusarium oxysporum f | 2004 | Molecu- lar Plant-Microbe Interaction2004，17，6： | 1 |
| 11 | Erythropoietin restores glu- tathione peroxidease activitY in 1-methyi-4-phenly-l,2,5,6-tetrahy- dropyridine- induced neurotoxicity in C57BL mice and stimulates routine as troglial glutathione peroxidase production in vitro显示文摘 | Gene S Akhisaroglu M Kuralay F | 2002 | Neu- rosci Lett2002，321，12： | 1 |
| 12 | Molecular and phenotypicdata supporting distinct species statuses for Scedosporiumapiospermum and Pseudallescheria boydii and the newspecies Scedosporium dehoogii显示文摘 | Gilgado F Cano J Gene J | 2008 | Journal of ClinicalMicrobiology2008，46，2： | 1 |
| 13 | Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin显示文摘 | Gene L Bidwell Izabela F | 2007 | Biochemical pharmacology2007，73，： | 1 |
| 14 | Erythropoietlu restores glutathione peroxidase activity in 1- methyl- 4 -phenly- 1,2,5 6 -tetrahydropyridine- induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro显示文摘 | Gene S Akhisaroglu M Kuralay F | 2002 | Neurosci Lett2002，321，12： | 1 |
| 15 | The Evolving Marketing Concept, Competitive Intensity And Organaizational Performance 显示文摘 | ROBERT F L GENE R L | 1987 | Journal of The Acadenay of Marketing Science1987，15，3： | 1 |
| 16 | ponders and nonresponders to recombinant hepatitisB vaccine 显示文摘 | Soroosh P Shokri F Azizi M Analysis of T-cell receptor betachain variable gene segment usage in healthy adult re | 2003 | Scand J Immunol2003，57，5： | 1 |
| 17 | An analysis of the total least squares problem 显示文摘 | Gene H Golub Charles F Van Loan | 1980 | SIAM Journal on Numerical Analysis1980，6，17： | 1 |
| 18 | Sodium ni-tniprusside and toxic epidermal necrolysis显示文摘 | Kilic M Ozturk F Gene G | 2012 | Asian Pac J Allery Jmmunol2012，30，3： | 1 |
| 19 | Influence of electron donor, oxygen, and redox potential on bacterial perchlorate degradation 显示文摘 | Joshua D S Gene F P | 2006 | Water Research2006，40，6： | 1 |
| 20 | Molecular phylogeny ofthe Pseudallescheria boydii species complex: proposal oftwo new species显示文摘 | Gilgado F Cano J Gene J | 2005 | Journal of Clinical Microbiology2005，43，10： | 1 |
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