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12篇 您的检索式:作者名="Gennady P"
    题名 作者 年代 出处 被引量
1Results of combined surgery by phacoemulsification and vitrectomy 显示文摘Ayala P Gennady L Guy K 2004IMAJ2004,3,1:1
2On the theory of thermal stresses in a thin bonding layer 显示文摘CHEREPANOV GENNADY P 1995Journal of Applied Physics (S0021-8979)1995,78,11:1
3Extreme value Theory as a Risk management Tool显示文摘Embrechts P Resnick I Gennady S 1999North American Actuarial Journal1999,3,2:1
4Architectural Tradeoffs for Survivor Sequence Memory Management in Viterbi Decoder 显示文摘Gennady Feygin P G Gulak 1993IEEE Transactions on Communications1993,41,3:1
5Double-supply-frequency pressure pulsation in annular linear induction pump显示文摘Hideo Araseki Igor R Kirillov Gennady V Preslitsky Anatoly P Ogorodnikov 2000Nuclear Engineering and Design2000,,1:1
6Primary structures of two ribonucleases from ginseng calluses:New members of the PR-10 family of intracellular pathogenesis-related plant proteins 显示文摘Gennady P Moiseyeva Larisa I 1997FEBS Letters1997,407,2:1
7New ap- proach to the synthesis of phthalo cyanines containing strong accepting and donating groups显示文摘Evgeny V Kudrik Ivan U Nikolaev Gennady P 2000Org Chem2000,10,6:1
8Bininda-Emonds and Alexei V Abramov Morphological variability and evolution of the baculum (os penis) in Mustelidae (Carnivora) 显示文摘Gennady F B Olaf R P 2003Journal of Mammalogy2003,84,2:1
9Architectural Tradeoffs for Survivor Sequence Memory Management inViterbi Decoder显示文摘Gennady Feygin P G Gulak 1993IEEE Transations on Communications1993,41,3:1
10Vertical ZnOnanorod/Si contact light-emitting diode显示文摘Hakdong C Gennady P Wonkang T 2011AppliedPhysics Letters2011,98,09:1
11Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls:Nanoshuttles for targeted on-demand theranostics显示文摘Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis,efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles(NP)-embedded silica nanoshuttles(MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin(DOX), a cancer drug, was loaded in the MGNSs as a payload. DOX loaded MGNSs were encapsulated in heat and pH sensitive polymer P(NIPAM-coMAA) to enable controlled release of the payload. Magnetically-guided transport of MGNSs was examined in:(a) a glass capillary tube to simulate their delivery via blood vessels; and(b) porous hydrogels to simulate their transport in composite human tissues, including bone, cartilage, tendon, muscles and blood–brain barrier(BBB). The viscoelastic properties of hydrogels were examined by atomic force microscopy(AFM). Cellular uptake of DOXloaded MGNSs and the subsequent pH and temperature-mediated release were demonstrated in differentiated human neurons derived from induced pluripotent stem cells(iPSCs) as well as epithelial HeL a cells. The presence of embedded iron and gold NPs in silica shells and polymer-coating are supported by SEM and TEM. Fluorescence spectroscopy and microscopy documented DOX loading in the MGNSs. Time-dependent transport of MGNSs guided by an external magnetic field was observed in both glass capillary tubes and in the porous hydrogel. AFM results affirmed that the stiffness of the hydrogels model the rigidity range from soft tissues to bone. pH and temperature-dependent drug release analysis showed stimuli responsive and gradual drug release. Cells' viability MTT assays showed that MGNSs are non-toxic. The cell death from on-demand DOX release was observed in both neurons and epithelial cells even though the drug release efficiency was higher in neurons. Therefore, development of smart nanoshuttles have significant translational potential for controlled delivery of theranostics' payloads and precisely guided transport in specified tissues and organs(for example, bone, cartilage, tendon, bone marrow, heart,lung, liver, kidney, and brain) for highly efficient personalized medicine applications.Liping Wang Grace Jang Deependra Kumar Ban Vrinda Sant Jay Seth Sami Kazmi Nirav Patel Qingqing Yang Joon Lee Woraphong Janetanakit Shanshan Wang Brian P Head Gennadi Glinsky Ratneshwar Lai 2017Bone Research2017,5,4:1
12Identification of an O-linked repetitive glycan chain of the polar flagellum flagellin of Azospirillum brasilense Sp7 显示文摘Alexei Ye Belyakov Gennady L Burygin Nikolai P Arbatsky 2012Carbohydrate Research2012,361,:1
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