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2篇 您的检索式：作者名="Geoffrey L. Liu"

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		题名	作者	年代	出处	被引量
	1	Distally Based Dorsal Pedal Neurocutaneous Flap for Forefoot Coverage显示文摘	Wengang Huang Dong Liu Geoffrey L. Robb Qixu Zhang	2011	Annals of Plastic Surgery2011，，3：	1
	2	Effects of milrinone on inflammatory response-related gene expressions in cultured rat cardiomyocytes显示文摘Congestive heart failure(CHF)is defined as a cardiac dysfunction leading to low cardiac output and inadequate tissue perfusion.Intravenous positive inotropes are used to increase myocardial contractility in hospitalized patients with advanced heart failure.Milrinone is a phosphodiesterase Ⅲ inhibitor and used most commonly for inotropic effect.The well-known PROMISE study investigated the effects of milrinone on mortality in patients with severe CHF,and concluded that long-term therapy with milrinone increased morbidity and mortality armong patients with advanced CHF.Previous studies have suggested that phosphodiesterase inhibitors can have potential effects on inflammatory pathways.Hence,we hypothesized that milrinone may alter inflammatory gene expressions in cardiomyocytes,thus leading to adverse clinical outcomes.We used rat cardiomyocyte cell line H9 C2 and studied the impact of exposing cardiomyocytes to milrinone(10 μmol/L)for 24 hours on inflammatory gene expressions.RNA extracted from cultured cardiomyocytes was used for whole rat genome gene expression assay(41 000 genes).The following changes in inflammatory response-related gene expressions were discovered.Genes with increased expressions included:THBS2(+ 9.98),MMP2(+3.47),DDIT3(+2.39),and ADORA3(+3.5).Genes with decreased expressions were:SPP1(-5.28)and CD14(-2.05).We found that the above mentioned gene expression changes seem to indicate that milrinone may hinder the inflammatory process which may potentially lead to adverse clinical outcomes.However,further in vivo and clinical investigations will be needed to illustrate the clinical relevance of these gene expression changes induced by milrinone.	Archana G. Venakatesh Johann J. Mathew Scott Coleman Longqiu Yang Geoffrey L. Liu Marilyn M. Li Henry Liu	2019	The Journal of Biomedical Research2019，33，4：	0

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