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| 1 | Irritable bowel syndrome: A concise review of current treatment concepts显示文摘Irritable bowel syndrome(IBS) is one of the most common gastrointestinal disorders causing patients to seek medical treatment. It is relatively resource intensive and the source of significant morbidity. Recent insights into the pathophysiology and treatment of IBS has given clinicians more options than ever to contend with this disorder. The purpose of our paper is to review older, 'classic' treatments for IBS as well as newer agents and 'alternative' therapies. We discuss the evidence base of these drugs and provide context to help develop appropriate treatment plans for IBS patients. | Geoffrey C Wall Ginelle A Bryant Michelle M Bottenberg Erik D Maki rew R Miesner | 2014 | World Journal of Gastroenterology2014，20，27： | 5 |
| 2 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 3 | Presence of phthalates in gastrointestinal medications: Is there a hidden danger?显示文摘Pharmaceutical companies that produce gastrointestinal(GI)medications often utilize phthalates for their ability to localize medication release.Commonly prescribed GI medications that may utilize phthalates are 5-Aminosalicylates,proton pump inhibitors,and pancreatic enzymes.Our understanding of the cumulative health effects of phthalates from medications remains unclear,and there is increasing evidence that phthalates are not harmless.Experimental studies in animals have shown that phthalates,specifically dibutyl phthalate and Di-(2-ethyl-hexyl)phthalate,have the potential to alter and/or inhibit reproductive biology and in utero development.Despite the lack of definitive human data,many cohort and cross-sectional studies demonstrate concerning associations between phthalates and poor health status,specifically developmental problems.Longitudinal studies and studies with larger sample sizes are required to determine whether phthalates actually cause negative health consequences.It is also important that physicians regularly review and discuss with patients the medicinal ingredients in their medications and supplements,specifically in pregnant woman with inflammatory bowel disease. | Zane R Gallinger Geoffrey C Nguyen | 2013 | World Journal of Gastroenterology2013，19，41： | 2 |
| 4 | The in vivo cardiovascular effects of box jellyfish Chironex fleckeri venom in rats efficacy of pre-treatment with antivenom, verapamil and magnesium sulphate显示文摘 | Sharmaine R Geoffrey K Seymour E | 2004 | Toxicon2004，43，： | 1 |
| 5 | Opal and inverse opal photonic crystals: Fabrication and characterization 显示文摘 | Geoffrey I N Waterhouse Mark R Waterland | 2007 | Polyhedron2007，26，： | 1 |
| 6 | Effect of organic-matter type and thermal maturity on methane adsorption in shale-gas systems显示文摘 | Zhang T Geoffrey S E Stephen C R etal | 2012 | Organic Geo- chemistry2012，47，： | 1 |
| 7 | Ecotourism: Towards Congruence between Theory and Praetiee显示文摘 | Sheryl R Geoffrey W | 1999 | Tourism Managemertt1999，，20： | 1 |
| 8 | Immunocontraception is induced in BALB/c mice inoculated with murine cytomegalovirus expressing mouse zona pellucida3显示文摘 | Lloyd Megan L Shellam Geoffrey R Papadimitriou John M | 2003 | Biol Reprod2003，68，6： | 1 |
| 9 | Simulation of potassium feldspar dissolution and illitization in the Statfjord Formation,North Sea显示文摘 | GEOFFREY T BERNARD P B MOGENS R | 2001 | AAPG Bulletin2001，85，4： | 1 |
| 10 | Selenium:an essential element for immune function显示文摘 | Roderick C M Teresa S R Geoffrey J B | 1998 | Immunology today1998，19，8： | 1 |
| 11 | Pyrolysis of inulin,glucose,and fructose显示文摘 | GLENN R P GEOFFREY N R | 1993 | Carbohyd Res1993，24，2： | 1 |
| 12 | Crystal structure of Co2EDTA·2H2O and preferential site occupation in CoNiEDTA·2H2O显示文摘 | Pedro G R Geoffrey B J Coronado E :Low-dimensional bimetallic ordered systems:synthesis and characterization of the isomorphous series CoxNi2-x EDTA·2H2O | 1986 | Inorg Chem1986，25，： | 1 |
| 13 | Obesitygene variant and elite endurance performance显示文摘 | Moore Geoffrey E Shuldiner Alan R Zmuda J0seph M Ferrell Robert E Mccole Steve D Hagberg James M | 2001 | Metabolism Clinical and Experimental2001，50，12： | 1 |
| 14 | Comparison of amyloidplaque contrast generated by T2-, T2* -, and susceptibility-weighted imaging methods in transgenic mouse models ofAlzheimer’s disease 显示文摘 | Ryan C Denise R Geoffrey LC | 2009 | Magn Reson Med2009，61，5： | 1 |
| 15 | Evaluation of the quality of sandalwood essential oils by gas chro- matography-mass spectrometry 显示文摘 | Mdanie-Jayne R Howes Monique S J Simmonds Geoffrey C Kite | 2004 | Journal of Chromatography A2004，1028，： | 1 |
| 16 | Flow of Wormlike Micelle Solu- tions Through a Periodic Array of Cylinders显示文摘 | Geoffrey R M Jonathan P R | 2010 | Journal of Non - Newtonian Fluid Mechanics2010，，165： | 1 |
| 17 | Transmitter diversity for OFDM systems and its impact on high-rate data wireless networks显示文摘 | Justin C Chuang Nelson R Sollenberger | 1999 | IEEE Journal on SAC1999，17，7： | 1 |
| 18 | Improved space-time coding for MIMO-OFDM wireless communications显示文摘 | Blum R S Li Ye(Geoffrey) Winters J H | 2001 | IEEE Trans on Com2001，49，11： | 1 |
| 19 | Adaptive antenna arrays for OFDM systems with co-channel interference显示文摘 | Nelson R Sollenberger | 1999 | IEEE Trans on Com1999，47，2： | 1 |
| 20 | Introduction of Pulse Shapes and Durations into Impulse-Momentmn Collision Models显示文摘 | GEOFFREY J G GEE R S | 2005 | SAE2005，，1： | 1 |
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