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| 1 | Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR:A systematic literature review显示文摘AIM:To review literature on efficacy and safety of octreotide-long-acting repeatable(LAR)used at doses higher than the Food and Drug Administration(FDA)-approved 30 mg/mo for treatment of neuroendocrine tumors(NETs).METHODS:We searched Pub Med and Cochrane Library from 1998-2012,5 conferences(American Society of Clinical Oncology,Endocrine Society,European Neuroendocrine Tumor Society,European Society for Medical Oncology,North American Neuroendocrine Tumor Society)from 2000-2013 using Me SH and keyterms including neuroendocrine tumors,carcinoid tumor,carcinoma,neuroendocrine,and octreotide.Bibliographies of accepted articles were also searched.Two reviewers reviewed titles,abstracts,and full-length articles.Studies that reported data on efficacy and safety of≥30 mg/mo octreotide-LAR for NETs in human subjects,published in any language were included in the review.RESULTS:The search identified 1086 publications,of which 238 underwent full-text review(20 were translated into English);17 were included in the review.Studies varied in designs,subjects,octreotide-LAR regimens,and definition of outcomes.Eleven studies reported use of higher doses to control symptoms and tumor progression,although symptom severity and formal quality-of-life analysis were not quantitatively measured.Ten studies reported efficacy,describing 260 subjects with doses ranging from 40 mg/mo or 30 mg/3 wk up to 120 mg/mo.Eight studies reported expert clinical opinion that supported dose escalation of octreotide-LAR up to 60 mg/mo for symptom control and suggested increased doses may be effective at preventing tumor progression.Eight studies reported safety;there was no evidence of increased toxicity associated with doses of octreotide-LAR>30 mg/mo.CONCLUSION:As reported in this review,octreotide-LAR at doses>30 mg/mo is being prescribed for symptom and tumor control in NET patients.Furthermore,expert clinical opinion provided support for escalation of somatostatin analogs for refractory hormonal symptoms. | Michael S Broder David Beenhouwer Jonathan R Strosberg Maureen P Neary Dasha Cherepanov | 2015 | World Journal of Gastroenterology2015，21，6： | 8 |
| 2 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 3 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 4 | Tucker,performance of wdm ring and bus networks in the present of homodyne crosstalk显示文摘 | Jonathan P R Lacey Rodney S | 1999 | Journal of Lightwave Technology1999，17，3： | 1 |
| 5 | Reassessing risk in developing country infrastructure显示文摘 | Jonathan P D Ravi R | 2003 | Long Range Planning2003，36，2： | 1 |
| 6 | Fielding, Sequence architecture within a low-accommodation setting:An example from te Permian of theGalilee and Bowen basins, Queensland, Australia 显示文摘 | Jonathan P Allen Christopher R | 2007 | AAPG2007，91，11： | 1 |
| 7 | BMP-7 and proximal tubule epithelial cells:activation of multiple signaling pathways reveals a novel anti-fibrotic mechanism显示文摘 | Motazed R Colville-Nash P Jonathan T | 2008 | Pharm Res2008，25，10： | 1 |
| 8 | Sequence architecture within a low- accommodation setting: An example from the Permian of the Galilee and Bowen basins 显示文摘 | Jonathan P Allen Christopher R Fielding | 2007 | AAPG Bulletin2007，91，11： | 1 |
| 9 | Sequence architecture within a low-accommodation setting : An example from the Permian of the Galilee and Bowen basins, Queensland, Australia 显示文摘 | Jonathan P A Christopher R F | 2007 | AAPG Bul- letin2007，91，11： | 1 |
| 10 | Flow of Wormlike Micelle Solu- tions Through a Periodic Array of Cylinders显示文摘 | Geoffrey R M Jonathan P R | 2010 | Journal of Non - Newtonian Fluid Mechanics2010，，165： | 1 |
| 11 | Outlook for ellulase improvement: Screening and selection strategies 显示文摘 | Zhang Y H P Michael E H Jonathan R M | 2006 | Biotechnology Advances2006，24，： | 1 |
| 12 | Consensus-degen- erate hybrid oligonucleotide primers (CODEHOPs)for the detec- tion of novel viruses in non-human primates显示文摘 | Jeannette P S Jonathan T R Gregory B | 2009 | Methods2009，49，1： | 1 |
| 13 | The Importance of Precautionary Motives in Explaining Individual and Aggregate Saving显示文摘 | Hubbard R Glenn Jonathan Skinner Stephen P Zeldes | 1994 | Carnegie-Rochester Conference Series on Public Policy1994，，40： | 1 |
| 14 | Room temperature ionic liquids as novel media for 'clean' liq uid-liquid extraction 显示文摘 | Huddleston Jonathan G Willauer Heather D Swatloski R P | 1998 | Chemical Communications1998，16，1： | 1 |
| 15 | Meta-Analysis of Calcium Supplementation for the Prevention of Postmenopausal Osteoporosis显示文摘 | Beverley S George W Ann C Nicole Z Vivian R Lauren G Zulma O Joan P Jonathan A Peter T Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 16 | Phosphorylation of phosp- hazenes and its effects on thermal properties and rire re- tardant behavior显示文摘 | Allcock H R Jonathan P T | 2007 | Polymer Engine ering and Science2007，40，： | 1 |
| 17 | CD44 is required for two consecutive steps in HGF/c-Met signaling显示文摘 | Véronique O R Chen L F Jonathan P | 2002 | Gene & Development2002，16，23： | 1 |
| 18 | Laminar drag reduction in microchannels using uhrahydrophobic surfaces 显示文摘 | Jia O Blair P Jonathan P R | 2004 | Physics Fluids2004，16，12： | 1 |
| 19 | Estimating hydrogen pro-duction potential in biorefineries using microbial electrolysis celltechnology显示文摘 | Abhijeet P Borole Jonathan R Mielenz | 2011 | International Journal of Hydrogen Energy2011，36，14： | 1 |
| 20 | Corporate Social Responsibility, Public Policy, and NGO Activism in Europe and the United States: An Institutional - Stakeholder Perspective 显示文摘 | Jonathan P Doh Terrence R Guay | 2006 | Journal of Management Studies2006，43，1： | 1 |
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