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| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | Late results after transurethral bladder neck incision显示文摘 | Neykov KG Panchev P Georgiev M | 1998 | Eur Urol1998，33，1： | 2 |
| 3 | Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family显示文摘AIM: To present novel frameshift mutation c.31delC [p.L11X] in the MLH1 gene identified in an extended Bulgarian hereditary non-polyposis colorectal cancer (HNPCC) family and to analyze the molecular and clinical findings within the pedigree concerning the proposal of adequate individual prophylactic strategy for all mutation carriers. METHODS: The pedigree of the family consists of 42 members in four generations. Search for mutations in the MLH1 and hMSH2 genes was performed in the pro-band. After PCR amplification of all exons including flanking intronic regions, amplicons were directly sequenced. RESULTS: The mutation was found in nine from the thirteen pedigree members who signed informed consent to participate in the study. In three adenocarcinomas, microsatellite instability and lack of the MLH1 protein expression were detected. The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining. CONCLUSION: The newly described mutation c.31delC is HNPCC causative. Besides the typical clinical features of the syndrome, we found a specific pathologic manifestation such as moderate to high differentiated adenocarcinomas of the colon. One of the mutation carriers developed a benign giant cell soft tissue tumor. The primary tumor localizations were frequently extracolonic and detailed yearly gastrointestinal and gynecological examinations have been proposed to the mutation carriers. We emphasize the importance of including the HNPCC genetic counseling and testing as well in the following surveillance of all patients at risk in the services covered by the health insurance in Bulgaria. | Tanya Kirilova Kadiyska Radka Petrova Kaneva Dimitar Georgiev Nedin Alexandrina Borisova Alexandrova Antonina Todorova Gegova Stoyan Ganchev Lalchev Tatyana Christova Vanio Ivanov Mitev Juergen Horst Nadja Bogdanova Ivo Marinov Kremensky | 2006 | World Journal of Gastroenterology2006，12，48： | 2 |
| 4 | Existence of a solution of the wave equation with nonlinear damping and source termd显示文摘 | Georgiev V Todorova G | 1994 | J Diff Equ1994，109，2： | 2 |
| 5 | Existence of solutions of the wave equation with nonlinear damping and source terms显示文摘 | Georgiev V Tdorova G | 1994 | J Differential Equations1994，109，： | 1 |
| 6 | First in situ determination ofground and borehole thermal properties in LatinAmerica 显示文摘 | P ROTH A GEORGIEV | 2004 | Renewable Energy2004，29，12： | 1 |
| 7 | Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01显示文摘 | Zhou T Georgiev L Wu X | | 0，，5993： | 1 |
| 8 | Brdf study of gray-scale spectralon显示文摘 | GEORGIEV G T BUTLERB J J | 2008 | SPIE2008，7081，： | 1 |
| 9 | Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal horn neurons 显示文摘 | Georgiev SK Furue H Baba H | 2010 | Mol Pain2010，6，： | 1 |
| 10 | Nonparametric function recovering from noisy observations显示文摘 | GEORGIEV A A GREBLICKI W | 1986 | Journal of Statistical Planning and Inference1986，13，1： | 1 |
| 11 | Sparse component analysis and blind source separation of underdetermined mixtures 显示文摘 | P G Georgiev F Theis A Cichocki | 2005 | IEEE Transactions on Neural Network2005，16，4： | 1 |
| 12 | Two-photon induced polarization spectroscopy applied to the detection of NH3 and CO molecules in cold flows and flames显示文摘 | FRITZON R GEORGIEV N | 1995 | Opt Commun1995，114，： | 1 |
| 13 | Cheap two-axis sun following device 显示文摘 | ROTH P GEORGIEV A BOUDINOV H | 2005 | Energy Conversion and Management2005，46，78： | 1 |
| 14 | Role of oxida-tive stress and DNA damage in human carcinogenesis显示文摘 | Kryston TB Georgiev AB Pissis P | 2011 | Mutat Res2011，711，12： | 1 |
| 15 | Sparse component analysis and blind source separation of underdetermined mixtures显示文摘 | Georgiev P Theis F Cichocki A | 2005 | IEEE Transactions on Networks2005，，： | 1 |
| 16 | The Effects of the Pressure and the Oxygen Content of the Sputtering Gas on the Structure and the Properties of Zinc Oxy-Nitride Thin Films Deposited by Reactive Sputtering of Zinc 显示文摘 | Jiang N Georgiev D G Jayatissa A H | 2013 | Semi- conductor Science and Technology2013，28，25： | 1 |
| 17 | Consistent nonparametric multiple regression: the fixed design case显示文摘 | GEORGIEV A A | 1988 | Journal of Multi?variate Analysis1988，25，1： | 1 |
| 18 | Pulse wave transit time measure-ments of cardiac output in septic shock patients: a comparison of the estimated continuous cardiac output system with transthoracic echocardiography 显示文摘 | Feissel M Aho LS Georgiev S | 2015 | PLoS ONE2015，10，01： | 1 |
| 19 | Cracking of cherry fruits, its causes and control显示文摘 | Georgiev S Milenkov M | 1973 | B” lgarski Plodove Zelenchutsi-iKonservi1973，，3： | 1 |
| 20 | Sun following system adjustment at the UTFSM 显示文摘 | GEORGIEV A ROTH P OLIVARES A | 2004 | Energy Conversion and Management2004，45，1112： | 1 |
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