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| 1 | Capecitabine for locally advanced and metastatic colorectal cancer:A review显示文摘Capecitabine (Xeloda) is an oral fluoropyrimidine which is produced as a pro-drug of fluorouracil, and shows improved tolerability and intratumor drug concentrations following its tumor-specif ic conversion to the active drug. We have searched the Pubmed and Cochrane databases from 1980 to 2009 with the purpose of reviewing all available information on Capecitabine, focusing on its clinical effectiveness against colorectal cancer. Special attention has been paid to trials that compared Capecitabine with standard folinic acid (leucovorin, LV)-modulated intravenous 5-fluorouracil (5-FU) bolus regimens in patients with metastatic colorectal cancer. Moreover the efficacy of Capecitabine on metastatic colorectal cancer, either alone or in various combinations with other active drugs such as Irinotecan and Oxaliplatin was also assessed. Finally, neoadjuvant therapy con- sisting of Capecitabine plus radiation therapy, for locally advanced rectal cancer was analysed. This combination of chemotherapy and radiotherapy has a special role in tumor down staging and in sphincter preservation for lower rectal tumors. Comparative trials have shown that Capecitabine is at least equivalent to the standard LV-5-FU combination in relation to progression-free and overall survival whilst showing a better tolerability prof ile with a much lower incidence of stomatitis. It is now known that Capecitabine can be combined with other active drugs such as Irinotecan and Oxaliplatin. The combination of Oxaliplatin with Capecitabine represents a new standard of care for metastatic colorectal cancer. Combinating the Capecitabine-Oxaliplatin regimen with promising new biological drugs such as Bevacizumab seems to give a realistic prospect of further improvement in time to progression of metastatic disease. Moreover, preoperative chemo-radiation using oral capecitabine is better tolerated than bolus 5-FU and is more effective in the promotion of both down-staging and sphincter preservation in patients with locally advanced rectal cancer. Finally, the outcomes of recently published trials suggest that capecitabine seems to be more cost effective than other standard treatments for the management of patients with colorectal cancer. | Georgios V Koukourakis Georgios Zacharias John Tsalafoutas Dimitrios Theodoridis Vassilios Kouloulias | 2010 | World Journal of Gastrointestinal Oncology2010，2，8： | 4 |
| 2 | Influence of building density and roof shape on the wind and dispersion characteristics in an urban area: a numerical study显示文摘 | THEODORIDIS GEORGIOS MOUSSIOPOULOS NICOLAS | 2000 | Environmental Monitoring and Assessment2000，65，11： | 1 |
| 3 | Flow and Sequential Injection Manifolds for the Spectrophotometric Determination of Captopril Based on its Oxidation by Fe(III)显示文摘 | Paraskevas D. Tzanavaras Demetrius G. Themelis Anastasios Economou Georgios Theodoridis | 2003 | Microchimica Acta (-)2003，，1： | 1 |
| 4 | Determination of anabolic steroids in muscle tissue by liquid chromatography–tandem mass spectrometry显示文摘 | George Kaklamanos Georgios Theodoridis Themistoklis Dabalis | 2009 | Journal of Chromatography A2009，，46： | 1 |
| 5 | Map-matched trajectory compression显示文摘 | Georgios Kellaris Nikos Pelekis Yannis Theodoridis | 2013 | The Journal of Systems & Software2013，，6： | 1 |
| 6 | Preparation of a molecularly imprintedpolymer for the solid-phase extraction of scopolamine withhyoscyamine as a dummy template molecule 显示文摘 | Georgios Theodoridis Andreas Kantifes PanagiotisManesiotis | 2003 | Journal ofChromatography A2003，987，12： | 1 |
| 7 | Influence of Building Density and Roof Shape on the Wind and Dispersion Characteristics in an Urban Area: A Numerical Study显示文摘 | Georgios Theodoridis Nicolas Moussiopoulos | 2000 | Environmental Monitoring and Assessment (-)2000，，1： | 1 |
| 8 | Preparation of a molecularly imprinted polymer for the solid-phase extraction of scopolamine with hyoscyamine as a dummy template molecule显示文摘 | Georgios Theodoridis Andreas Kantifes Panagiotis Manesi- otis | 2003 | Journal of Chromatography A2003，，987： | 1 |
| 9 | Determination of Anabolic Steroidsin Muscle Tissue by Liquid Chromatography - Tandem Mass Spectrometry 显示文摘 | George Kaklamanos Georgios Theodoridis Themistoklis Dabalis | 2009 | Journal of Chromato - Graphy A2009，1216，： | 1 |
| 10 | GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2)drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine显示文摘Acetazolamide(molecular mass(MM),222)belongs to the class of sulfonamides(R-SO2-NH2)and is one of the strongest pharmacological inhibitors of carbonic anhydrase activity.Acetazolamide is excreted unchanged in the urine.Here,we report on the development,validation and biomedical application of a stable-isotope dilution GC-MS method for the reliable quantitative determination of acetazolamide in human urine.The method is based on evaporation to dryness of 50 mL urine aliquots,base-catalyzed derivatization of acetazolamide(d0-AZM)and its internal standard[acetylo-2H3]acetazolamide(d3-AZM)in 30 vol%pentafluorobenzyl(PFB)bromide in acetonitrile(60 min,30C),reconstitution in toluene(200 mL)and injection of 1-mL aliquots.The negative-ion chemical ionization(NICI)mass spectra(methane)of the PFB derivatives contained several intense ions including[M]‒at m/z 581 for d0-AZM and m/z 584 for d3-AZM,suggesting derivatization of their sulfonamide groups to form N,N-dipentafluorobenzyl derivatives(R-SO2-N(PFB)2),i.e.,d0-AZM-(PFB)2 and d3-AZM-(PFB)2,respectively.Quantification was performed by selected-ion monitoring of m/z 581 and 83 for d0-AZM-(PFB)2 and m/z 584 and 86 for d3-AZM-(PFB)2.The limits of detection and quantitation of the method were determined to be 300 fmol(67 pg)and 1 mM of acetazolamide,respectively.Intra-and inter-assay precision and accuracy for acetazolamide in human urine samples in pharmacologically relevant concentration ranges were determined to be 0.3%e4.2%and 95.3%e109%,respectively.The method was applied to measure urinary acetazolamide excretion after ingestion of a 250 mg acetazolamide-containing tablet(Acemit®)by a healthy volunteer.Among other tested sulfonamide drugs,methazolamide(MM,236)was also found to form a N,N-dipentafluorobenzyl derivative,whereas dorzolamide(MM,324)was hardly detectable.No GC-MS peaks were obtained from the PFB bromide derivatization of hydrochlorothiazide(MM,298),xipamide(MM,355),indapamide and metholazone(MM,366 each)or brinzolamide(MM,384).We demonstrate for the first time that sulfonamide drugs can be derivatized with PFB bromide and quantitated by GC-MS.Sulfonamides with MM larger than 236 are likely to be derivatized by PFB bromide but to lack thermal stability. | Olga Begou Kathrin Drabert Georgios Theodoridis Dimitrios Tsikas | 2020 | Journal of Pharmaceutical Analysis2020，10，1： | 1 |
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