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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 3 | Higher differentiation among subspecies of the house mouse(Mus muscu/us )in genomic regions with low recombination显示文摘 | GERALDES A BASSET P SMITH K L | 2011 | Molecular Ecology2011，20，22： | 1 |
| 4 | Familial hypercholesterolemia: developments in diagnosis and treatment 显示文摘 | Gerald K Ulrich L Winfried M | 2014 | Dtsch Arztebl Int2014，111，3132： | 1 |
| 5 | HVOF-spray technology poised for growth显示文摘 | DANIEL W P GERALD L K | 1991 | Advanced Materials and Processes1991，，4： | 1 |
| 6 | Magneto-optic/eddy current imaging of aging aircratf: a new NDI technique显示文摘 | Fitzpatrick Gerald L Thome David K Skaugest Richard L | 1993 | Materials Evaluation1993，51，12： | 1 |
| 7 | Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer:evidence for involvement of AP-1 and PEA3显示文摘 | Subbaramaiah K Norton L Gerald W | 2002 | J BiolChem2002，27，18： | 1 |
| 8 | Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer:evidence for involvement of AP-1 and PEA3显示文摘 | Subbaramaiah K Norton L Gerald W | 2002 | J Biol Chem2002，277，18： | 1 |
| 9 | Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3显示文摘 | Subbaramaiah K Norton L Gerald W | 2002 | J Biol Chem2002，277，18： | 1 |
| 10 | Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer:evidence for involvement of AP-1 and PEA3显示文摘 | Subbaramaiah K Norton L Gerald W | 2002 | J Biol Chem2002，277，18： | 1 |
| 11 | Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3 显示文摘 | Norton L Gerald W | 2002 | J Biol Chem2002，277，18： | 1 |
| 12 | Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer:evidence for involvement of AP-1 and PEA3显示文摘 | Subbaramaiah K Norton L Gerald W | 2002 | J Biol Chem2002，277，18： | 1 |
| 13 | Intraabdominal desmoplastic small round-cell tumor: report of 19 cases of a distinctive type of high-grade polyphenotypic malignancy affecting young individuals显示文摘 | Gerald W L Miller H K Battifora H | 1991 | Anti Surg Pathol1991，15，6： | 1 |
| 14 | National Culture and Internal Control Material Weaknesses Around the World 显示文摘 | Kanagaretnam K Gerald J L Chen M Jian Z | 2016 | Journal of Accounting Auditing & Finance2016，31，1： | 1 |
| 15 | Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer显示文摘 | Subbaramaiah K Norton L Gerald W | 2002 | J Biol Chem2002，277，18： | 1 |
| 16 | Polycblorinated dioxins, furans, and biphenyls, and polybrominated diphenyl ethers in a US meat mar ket basket and estimates of dietary intake显示文摘 | Lanice K H Gerald L L | 2005 | Environ Sci Technol2005，，39： | 1 |
| 17 | Factors as- sociated with the failure of patients to complete cardiac rehabilitation for medical and nonmedical reasons显示文摘 | Sanderson B K Philips M M Gerald L | 2003 | J Cardiopulm Rehabil2003，23，4： | 1 |
| 18 | Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3 显示文摘 | Subbaramaiah K Norton L Gerald W | 2002 | Biol Chem2002，277，18： | 1 |
| 19 | A Real -time Video Tracking System显示文摘 | Gilbert Alton L Giles Michael K Flachs Gerald M | 1980 | IEEE Transactions on Pattern Analysis and Machine Intelligence1980，2，1： | 1 |
| 20 | Glycosylationof nucleocytoplasmic proteins : signal transduction and 0-glcNAc显示文摘 | WELLS L VOSSELLER K GERALD W H | 2001 | Science2001，291，5512： | 1 |
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