|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 3 | Genome-wide analysis of gene expression associated with MYCN in human neuroblastoma显示文摘 | Alaminos M Mora J Cheung NK Smith A Qin J Chen L Gerald WL | 2003 | Cancer Res2003，63，8： | 1 |
| 4 | Investigation of nanoporous carbon powders produced by high energy ball milling and formation of carbon nanotubes during subsequent annealing显示文摘 | Y CHEN J FITZ GERALD L T CHADDERTONL and L CHAFFRON | 1999 | Journal of Metastable and Nanocrystalline Materials1999，2，： | 1 |
| 5 | Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C2C12 myoblasts via Toll-like receptor-4 and c-Jun NH2-terminal kinase pathways显示文摘 | FROST R A GERALD J N CHARLES H L | 2004 | American Journal of Physiology Cell Physiology2004，287，： | 1 |
| 6 | A solid state process for formation of boron nitride nanotubes 显示文摘 | CHEN Y CHADDERTON L T GERALD J F | 1999 | Appl Phys Lett1999，74，： | 1 |
| 7 | A Solid-state process for formation of boron nitride 显示文摘 | Chen Y Chadderton L T Gerald J F | 1999 | Appl Phys Lett1999，74，： | 1 |
| 8 | Post-traumatic stress disor- der after weaning from prolonged mechanical ventilation 显示文摘 | Amal J Gerald L Lisa AD | 2010 | Intensive Care Med2010，36，12： | 1 |
| 9 | Nanoporous carbon produced by ball milling 显示文摘 | Chen Y Gerald J F Chadderton L T | 1999 | Applied physics letters1999，74，： | 1 |
| 10 | Localized fibrous tumor of the pleura显示文摘 | Melissa L Gerald F Teri J | 2003 | Radiographic2003，239，3： | 1 |
| 11 | A solid-state process for formation of boron nitride nanotubes显示文摘 | Chen Y Chadderton L T Fitz Gerald J | 1999 | Appl Phys Lett1999，74，20： | 1 |
| 12 | Case 2: desmoplastic small round cell tumor with divergent differentiation显示文摘 | Gerald W L Bosai J | 1989 | Pediatr Pathol1989，9，2： | 1 |
| 13 | Fundamentals of dry powder blending for metal matrix composites显示文摘 | Gerald P J Jayashree L Hani H | 1993 | The International Journal of Powder Metallurgy1993，29，4： | 1 |
| 14 | National Culture and Internal Control Material Weaknesses Around the World 显示文摘 | Kanagaretnam K Gerald J L Chen M Jian Z | 2016 | Journal of Accounting Auditing & Finance2016，31，1： | 1 |
| 15 | Investigation of flow patterns and mass transfer in membrane module channels filled with flow-aligned spacers using computational fluid dynamics (CFD)显示文摘 | Santos J L C Geraldes V Velizarov S Crespo J G | 2007 | Journal of Membrane Science2007，305，12： | 1 |
| 16 | The Effect of Economic Similarity-Dissimilarity as Determinants of Attraction显示文摘 | BYRNE D E GERALD L C J WORCHEL P | 1966 | Journal of Personality and Social Psychology1966，4，2： | 1 |
| 17 | An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification显示文摘 | Bianca J L Gerald F J | 2011 | J Am Chem Soc2011，133，： | 1 |
| 18 | Extraction Coupled with Liquid Chromatography/Electrospray Ionization Mass Spectrometry for the Simplified Determination of Imidazolinone Herbicides and Their Metabolites in Plant Tissue显示文摘 | STEVEN J S ADRIAN RD GERALD L P | 1996 | Journal of Agricultural and Food Chemistry1996，44，： | 1 |
| 19 | Localized fibrous tmors of the pleura显示文摘 | Melissa L Gerald F Teri J | 2003 | Radiopraphic2003，23，： | 1 |
| 20 | Predictors of online Buying Behavior显示文摘 | STEVEN BELLMAN GERALD L LOHSE ERIC J JOHNSON | 2009 | Communications of ACM2009，42，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员