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| 1 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 2 | Nonlinear acoustic echo cancellation based on volterra filters 显示文摘 | G Alexandre F Gerard L B J Regine | 2003 | IEEE Transactions on Speech and Audio Processing2003，11，6： | 1 |
| 3 | Isolation of cloned Moloney murine leukemia virus reverse transcriptase lacking ribonuclease H activity显示文摘 | KOTEWICZ M L SAMPSON C M DALESSIO J M GERARD G F | 1988 | Nucleic Acids Res1988，16，1： | 1 |
| 4 | Nonlinear a- coustic echo cancellation based on Volterra filters 显示文摘 | G Mexandre F Gerard and L B J Regine | 2003 | IEEE Transactions on Speech and Audio Processing2003，11，6： | 1 |
| 5 | cDNA synthesis by Moloney murine leukemia virus RNase H-minus reverse transcriptase possessing full DNA polymerase activity显示文摘 | GERARD G F SCHMIDT B J KOTEWICZ M L | 1992 | Fouse ( Life Technoligise)1992，14，： | 1 |
| 6 | Synthesis,structure and morphology of polymer-silica hybrid nanocomposite based on hydroxyethyl methacrylate显示文摘 | Hajji P David L Gerard J F Pascault J P Vigier G | 1999 | J Polym Sci:Polym Phys1999，37，22： | 1 |
| 7 | Reverse transcriptase显示文摘 | Gerard G F Fox D K Nathan M | | 0，，1： | 1 |
| 8 | cDNA synthesis by Moloney murine leukemia virus RNase H-minus reverse transcriptase possessing full DNA polymerase activity显示文摘 | Gerard G F Schmidt B J Kotewicz M L | 1992 | Focus (Life Technologies)1992，14，： | 1 |
| 9 | Nonlinear acoustic echo cancellation based on volterra filters 显示文摘 | G Alexandre F Gerard L B J Regine | 2003 | IEEE Transactions on Speech and Audio Processing2003，11，6： | 1 |
| 10 | Reverse transcriptase显示文摘 | GERARD G F FOX D K NATHAN M | 1997 | Molecular Biotechnology1997，8，1： | 1 |
| 11 | Hodgsonox, a new class of sesquiterpene from the liverwort Ltpidolaena hodgsoniae isolation directed by insecticidal activity 显示文摘 | Ainge G D Gerard P J Hinkley S F R | 2001 | J Org Chem2001，66，8： | 1 |
| 12 | A method for clone sequence confirmation using a mismatch-specific DNA endonuclease显示文摘 | Qiu P Shandilya H Gerard G F | 2005 | Mol Biotechnol2005，29，1： | 1 |
| 13 | ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article显示文摘 | Melvin D Cheitlin William F Armstrong Gerard P Aurigemma George A Beller Fredrick Z Bierman Jack L Davis Pamela S Douglas David P Faxon Linda D Gillam Thomas R Kimball William G Kussmaul Alan S Pearlman John T Philbrick Harry Rakowski Daniel M Thys Elliot | 2003 | Journal of the American College of Cardiology2003，，5： | 1 |
| 14 | Action and mo-tion planning for agile earth-observing satellites显示文摘 | ROMAIN G GERARD V ANTOINE F | 2012 | Acta Futura2012，，5： | 1 |
| 15 | Evolution of spontaneous atherosclerotic plaque rupture with medical therapy 显示文摘 | Gilles R Martine G Gerard F | 2004 | Circulation2004，110，： | 1 |
| 16 | Identification of a Drosophila melanogaster ICE/CED-3-related protease,drICE显示文摘 | Andrew G F Gerard I E | 1997 | The EMBO Journal1997，10，16： | 1 |
| 17 | Hodgsonox, a New Class of Sesquiterpene from the Liverwort Lepidolaena hodgsoniae Isolation Directed by Insecticidal Activity显示文摘 | AINGE G D GERARD P J Simon F R | 2001 | J Org Chem2001，66，： | 1 |
| 18 | Polyamide 11/poly ( hydroxy amino ether) blends: Influence of the blend composition and morphology on the barrier and mechanical properties 显示文摘 | Lafitte G Espuche E Gerard J F | 2011 | European Polymer Journal2011，47，10： | 1 |
| 19 | Novel inorganic franeworks constructed from double-fourring (D4R) units: computational design, structures, and lattice energies of silicate, alumin ophosphate, and gallophosphate candidates显示文摘 | Caroline M D Stephanie G Gerard F | 2002 | J Am Chem Soc2002，124，15： | 1 |
| 20 | Using enzymes to improve the process and the product quality in the recycled paper industry显示文摘 | JEAN-CLAUDE P JEAN-LUC F GERARD G | 1989 | Tappi Journal1989，72，6： | 1 |
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