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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Management and clinical outcomes of pregnant patients with invasive cervical cancer显示文摘 | Germann N Haie-Meder C Morice P | | 0，，： | 1 |
| 3 | Temperature fluctuations during deep temperature cryopreservation reduce PBMC recovery, viability and T-cell function显示文摘 | Anja Germann Young-Joo Oh Tomm Schmidt Uwe Sch?n Heiko Zimmermann Hagen von Briesen | 2013 | Cryobiology2013，，： | 1 |
| 4 | Preliminary results on the activity of oxaliplatin (L-OHP) in refractory/recurrent non-Hodgkin' s lymphoma patients显示文摘 | Germann N Brienza S Rotarski M | 1999 | Ann Oncol1999，10，3： | 1 |
| 5 | Stem-Iike cells with luminal progenitor phenotype survive castration in human prostate cancer显示文摘 | Germann M Wetterwald A Guzman -Ramirez N | 2012 | Stem Cells2012，30，： | 1 |
| 6 | Management and clinical outcomes of pregnant patients with invasive cervical cancer显示文摘 | Germann N Haie-Meder C Morice P | 2005 | Ann Oncol2005，16，： | 1 |
| 7 | Hypertonic, hyperoncotic hydroxyethyl starch decreases intratranial pressure following neurotrauma 显示文摘 | Weinstsabl C Mayer N Germann P | 1991 | Anesthesilogy1991，75，： | 1 |
| 8 | Anthmcyclines during -: embryo-fetal outcome in 160 patients 显示文摘 | Germann N Goffinet F Goldwasser F | 2004 | Ann Oneol2004，15，1： | 1 |
| 9 | Aesthetic breast augmentation显示文摘 | Reichenberger MA Biedermann N Germann G | | 0，，9： | 1 |
| 10 | Management and clinical outcomes of pregnant patients with invasive cervical cancer显示文摘 | Germann N Haie-Meder C Morice P | | 0，，03： | 1 |
| 11 | Intrinsic Flaps in theHand显示文摘 | Germann G Biedermann N Levin S | 2011 | Clinics in Plastic Surg2011，38，4： | 1 |
| 12 | Anthracyclines during pregnancy: embryo-fetal outcome in 160 patients显示文摘 | Germann N Goffinet F Goldwasser F | 2004 | Ann Oncol2004，15，1： | 1 |
| 13 | Preliminary results on the activity of oxaliplatin (L- OHP) in refractory/recurrent non- Hodgkin's lymphoma patients 显示文摘 | Germann N Brienza S Rotarski M | 1999 | Ann Oncol1999，10，3： | 1 |
| 14 | Anthracyclines during pregnancy:embryo-fetal outcome in 160 patients显示文摘 | GERMANN N GOFFINET F GOLDWASSER F | 2004 | Ann Oncol2004，15，1： | 1 |
| 15 | Aesthetic breast augmentation 显示文摘 | Reichenberger MA Biedermann N Germann G | 2011 | Chirurg2011，82，9： | 1 |
| 16 | Preliminary results on the activity of oxaliplatin ( L - OHP) in refrae-tory ! recurrent non - Hodgk ins' lymphoma patien ts 显示文摘 | Germann N Brien za S Rotarsk iM | 1999 | Ann Onco1999，10，3： | 1 |
| 17 | Preliminary results on the activity of oxaliplatin(L-OHP)in refractory/recurrent non-Hodgkin's lymphoma patients显示文摘 | Germann N Brienza S Rotarski M | 1999 | Ann Oncol1999，10，3： | 1 |
| 18 | Stem-like cells with luminal progenitor phenotype survive castration in human prostate cancer显示文摘 | Germann M Wetterwald A Guzman-Ramirez N | 2012 | Stem Cells2012，30，6： | 1 |
| 19 | Preliminary results on the activity of oxaliplatin (L-OHP) in refractory/recurrent nonHodgkin's lymphoma patients显示文摘 | Germann N Brienza S Rotarski M | | 0，，03： | 1 |
| 20 | Preliminary results on the activity of oxaliplatin ( L - OHP) in refractory/recurrent non - Hodgkin's lymphoma patients 显示文摘 | Germann N Brienza S Rotarski M | 1999 | Ann Oncol1999，10，3： | 1 |
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