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| 1 | 排土场散体软岩重塑物理力学参数研究显示文摘为了研究蒙东地区露天矿软岩散体物料重塑进程中的物理力学参数变化规律,依据该地区露天矿不同的排土作业方式,分析了堆载压力叠加方式,设计了分级加载和连续加载2种软岩重塑试验方案,提供了具体的试验步骤进行重塑试样的制备,对软岩重塑试样的物理力学强度进行了测定,结果表明:重塑岩样的孔隙比随着重塑压力的增大呈负指数规律递减,密度随着重塑压力的增大呈幂函数增长,含水率随重塑压力的增大呈对数关系递减;重塑岩样的黏聚力随重塑压力的增大呈二次函数规律增长,增长的速度逐渐下降;而内摩擦角不受重塑压力的影响。 | 韩流 舒继森 尚涛 陈树召 GERSON S V T | 2019 | 采矿与安全工程学报2019，36，4： | 22 |
| 2 | Anti-rods/rings autoantibody generation in hepatitis Cpatients during interferon-α/ribavirin therapy显示文摘Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon. | Gerson Dierley Keppeke S John Calise Edward KL Chan Luis Eduardo C Andrade | 2016 | World Journal of Gastroenterology2016，22，6： | 4 |
| 3 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 4 | Clinical relevance of MGMT in the treat- ment of cancer显示文摘 | Gerson S L | 2002 | J Clin Oncol2002，20，9： | 1 |
| 5 | The influence of sodium carbonate in sodium aluminosilicate crystallization and solubility in sodium aluminate solutions显示文摘 | ZHENG K L GERSON A R ADDAL-MENSAH J SMART R S C | 1997 | J Crystal Growth1997，171，： | 1 |
| 6 | Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy显示文摘 | Koc 0 N Gerson S L Cooper B W | 2000 | J Clin Oncol2000，18，2： | 1 |
| 7 | The evolution of surface layers formed during chalcopyfite leaching显示文摘 | HARMER S L THOMAS J E FORNASIERO D GERSON A R | 2006 | Geochimica et Cosmochimica Acta2006，70，17： | 1 |
| 8 | Spider mite webbing the production of webbing under various enviromental conditions 显示文摘 | HAZAN A GERSON U TAHORI A S | 1974 | Acarologia1974，16，： | 1 |
| 9 | Chemical colitis显示文摘 | Sheibani S Gerson LB | 2008 | J Clin Gastroenterol2008，42，2： | 1 |
| 10 | A Comparison of the Kinetics and Mechanism of Acid Leaching of Sphalerite Containing Low and High Concentrations of Iron显示文摘 | Weisener C G Smart R S C Gerson A R | 2004 | International Journal of Mineral Process2004，74，1234： | 1 |
| 11 | An investigationof the mechanism of gibbsite nucleation using molecularmodelling 显示文摘 | GERSON A R RALSTON J SMART R S C | 1996 | Colloids and Surfaces A-Physicochemical andEngineering Aspects1996，110，1： | 1 |
| 12 | Are lifestyle measures effective in patients with gastroesophageal reflux disease An evidence-based approach显示文摘 | Kaltenbach T Crockett S Gerson LB | | 0，，09： | 1 |
| 13 | ITS2 sequences as barcodes for identifying and analyzing spider mites (Acari: Tetranychidae) 显示文摘 | Ben D T Melamed S Gerson U | 2007 | Experimental and Applied Acarology2007，41，3： | 1 |
| 14 | 颗粒尺寸及倾角对渗流水压力分布的影响研究显示文摘为了研究颗粒尺寸及渗流倾角对水压力分布的影响规律,基于水力学基本原理,推导出了结构面渐进贯通过程中的静水压力以及多孔介质连续渗流过程中的渗透力计算方法,揭示了颗粒结构、倾角与水压力的函数关系。设计单因素渗流试验方案,分别以颗粒尺寸和渗流倾角为自变量,以压力水头为因变量,进行了9组循环渗流试验,测定了沿程压力水头。结果表明:渗透力未改变石子、中沙的颗粒排布结构,造成了细沙渗流路径上13^(#)水头管位置出现流沙沉降。沿程压力水头在石子、中沙内部分别呈'直角三角形'和'等腰三角形'分布,在细沙内部则呈现连续增长+骤降+水平波动+连续下降的分布规律。峰值压力水头分别出现在石子渗流路径的终点、中沙渗流路径的中点,以及细沙压力水头骤降区的起点。石子、中沙渗流的峰值压力水头△h_(max)与β,sinβ均符合良好的线性关系,细沙渗流的峰值压力水头与倾角符合二次函数关系。散体介质过流断面与底板出水孔透水能力的相对大小是决定压力水头峰值和分布规律的关键因素。 | 韩流 舒继森 尚涛 杨国宇 陈涛 李胤达 GERSON S V Tovele | 2021 | 采矿与安全工程学报2021，38，3： | 1 |
| 15 | Adverse drug reactions to cep- halosporins in hospitalized patients whit a history of penicillin allergy 显示文摘 | Fonacier L Hirschberg R Gerson S | 2005 | Allergy Asthma Proc2005，26，2： | 1 |
| 16 | vivo expansion and subsequentinfusion of human bone marrow derived atromal progenitor cells (mesenchymal progenitor cells):implications for the rapeuticuse显示文摘 | Haynesworth S Gerson S | 1995 | Bone Marrow Transplant1995，16，： | 1 |
| 17 | Galvanic corrosion of laser weldments of AA6061 aluminium alloy 显示文摘 | Rahman A Mujibur Kumar S Gerson A | 2007 | Corrosion Science2007，49，12： | 1 |
| 18 | Chemical colitis显示文摘 | SHEIBANI S GERSON L B | 2008 | J Clin Gastroenterol2008，42，2： | 1 |
| 19 | Miceover expressiong human O^6 - alkylguanine- DNA alkyltransferase lcetively reduced O^6 - methylguanine mediated cancinogenic mutations to threshold level salter N - methyl - N - nitrosourea显示文摘 | ALLAY E VEIGI M GERSON S L | 1999 | Oncogene1999，18，25： | 1 |
| 20 | Two - dimen- sional assessment of right ventricular function : an echocardiograph- ic - MRI correlative study 显示文摘 | ANAVEKAR N S GERSON D SKALI H | 2007 | Echocm''diograph2007，24，5： | 1 |
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