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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Cortically Coupled Computer Vision for Rapid Image Search显示文摘 | Parra L C Sajda P | 2006 | IEEE Transactions on Neural Systems and Rehabilitation Engineering2006，14，2： | 1 |
| 3 | Clinical relevance of MGMT in the treat- ment of cancer显示文摘 | Gerson S L | 2002 | J Clin Oncol2002，20，9： | 1 |
| 4 | Risk factors for small bowel bacte-rial overgrowth in cystic fibrosis显示文摘 | Fridge JL Conrad C Gerson L | 2006 | Pediatr Gastroenterol Nutr2006，44，2： | 1 |
| 5 | American Gastroenterological Association (AGA) Institute medical position statement on obscure gastrointestinal bleeding 显示文摘 | Raju GS Gerson L Das A American Gastroen- terological Association | 2007 | Gastroenterology2007，133，5： | 1 |
| 6 | American Gastroenterological Asso- ciation (AGA) Institute technical review on obscure gastrointestinal bleeding 显示文摘 | Raju GS Gerson L Das A | 2007 | Gastroenterology2007，133，5： | 1 |
| 7 | The influence of sodium carbonate in sodium aluminosilicate crystallization and solubility in sodium aluminate solutions显示文摘 | ZHENG K L GERSON A R ADDAL-MENSAH J SMART R S C | 1997 | J Crystal Growth1997，171，： | 1 |
| 8 | Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy显示文摘 | Koc 0 N Gerson S L Cooper B W | 2000 | J Clin Oncol2000，18，2： | 1 |
| 9 | The evolution of surface layers formed during chalcopyfite leaching显示文摘 | HARMER S L THOMAS J E FORNASIERO D GERSON A R | 2006 | Geochimica et Cosmochimica Acta2006，70，17： | 1 |
| 10 | Families' experience with seeking treatment for recent-onset psychosis 显示文摘 | Gerson R Davidson L Booty A | 2009 | Psychiatr Serv2009，60，6： | 1 |
| 11 | Reduced lung tumorigenesis in human methylguanine DNA-methyltransferase transgenic mice achieved by expression of transgene within the target cell显示文摘 | Liu L Qin X Gerson SL | 1999 | Carcinogenesis1999，20，2： | 1 |
| 12 | American Gastroenterological Association (AGA) Institute technical review on obscure gastrointestinal bleeding 显示文摘 | Raju GS Gerson L Das A American Gastroen- terological Association | 2007 | Gastroenterology2007，133，5： | 1 |
| 13 | Base excision repair as a therapeutic target in colon cancer 显示文摘 | Liu L Nakatsuru Y Gerson SL | 2002 | Clin Cancer Res2002，8，9： | 1 |
| 14 | Amenicn Gastroentreological Association(AGA) Institule Position statement on obsure gastrointestinal bleeding显示文摘 | Raj L Gerson L Das A | 2007 | Gastroantreology2007，133，： | 1 |
| 15 | Systematic review:the effects of carbonated beverages on gastro-oesophageal reflux disease显示文摘 | Johnson T Gerson L Hershcovici T | | 0，，06： | 1 |
| 16 | Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina 显示文摘 | Gao L Macklin W Gerson J | 2006 | Dev Biol2006，290，2： | 1 |
| 17 | American Gastroenterological Association (AGA)Institute technical review on obscure gastrointestinal bleeding显示文摘 | Raju GS Gerson L Das A | | 0，，05： | 1 |
| 18 | Adverse drug reactions to cep- halosporins in hospitalized patients whit a history of penicillin allergy 显示文摘 | Fonacier L Hirschberg R Gerson S | 2005 | Allergy Asthma Proc2005，26，2： | 1 |
| 19 | Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules 显示文摘 | Tolcher AW Gerson SL Denis L | 2003 | Br J Cancer2003，88，7： | 1 |
| 20 | Guidelines for the di- agnosis and management of gastroesophageal reflux dis- ease 显示文摘 | Katz P O Gerson L B Vela M F | 2013 | Am J Gastroenterol2013，108，3： | 1 |
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