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| 1 | Targeting the tumor stroma in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common and deadly cancers worldwide. In ninety percent of the cases it develops as a result of chronic liver damage and it is thus a typical inflammationrelated cancer characterized by the close relation between the tumor microenvironment and tumor cells. The stromal environment consists out of several cell types, including hepatic stellate cells, macrophages and endothelial cells. They are not just active bystanders in the pathogenesis of HCC, but play an important and active role in tumor initiation, progression and metastasis. Furthermore, the tumor itself influences these cells to create a background that is beneficial for sustaining tumor growth. One of the key players is the hepatic stellate cell, which is activated during liver damage and differentiates towards a myofibroblast-like cell. Activated stellate cells are responsible for the deposition of extracellular matrix, increase the production of angiogenic factors and stimulate the recruitment of macrophages. The increase of angiogenic factors(which are secreted by macrophages, tumor cells and activated stellate cells) will induce the formation of new blood vessels, thereby supplying the tumor with more oxygen and nutrients, thus supporting tumor growth and offering a passageway in the circulatory system. In addition, the secretion of chemokines by the tumor cells leads to the recruitment of tumor associated macrophages. These tumor associated macrophages are key actors of cancer-related inflammation, being the main type of inflammatory cells infiltrating the tumor environment and exerting a tumor promoting effect by secreting growth factors, stimulating angiogenesis and influ-encing the activation of stellate cells. This complex interplay between the several cell types involved in liver cancer emphasizes the need for targeting the tumor stroma in HCC patients. | Femke Heindryckx Pär Gerwins | 2015 | World Journal of Hepatology2015，7，2： | 16 |
| 2 | Effect of soil parameters on the cocrosion of archaeological metal finds显示文摘 | Gerwin W Baumhauer R | 2000 | Geoderma2000，96，2： | 1 |
| 3 | Erythroid-lineagespecific engraftment in patients with severe hemoglobinopathy following allogeneic hematopoietic stem cell transplantation显示文摘 | Armistead PM Mohseni M Gerwin R | 2008 | Exp Hematol2008，36，9： | 1 |
| 4 | Interrater reliability in myofas- cial trigger point examination显示文摘 | Gerwin R D Shannon S Hong C Z | 1997 | Pain1997，69，12： | 1 |
| 5 | Alternative operative exposure of the posterior aspect of the humural disphysis with reference to the radial nerve显示文摘 | GERWIN M HOTCHKISS R N WEILAND A J | 1996 | J Bone Joint Surg(Am)1996，78，： | 1 |
| 6 | Diagnosing fibromyalgia and myofascial pain syndrome: a guide显示文摘 | Gerwin R D | 2013 | J Fam Praet2013，62，12： | 1 |
| 7 | Alternative operative exposures of the posterior aspect of the humeral diaphysis with reference to the radial nerve显示文摘 | Gerwin M Hotchkiss R Weiland A | 1996 | Bone Joint Surg1996，11，： | 1 |
| 8 | Effect of soil parameters on corrosion ofarchaeological metal finds显示文摘 | Gerwin W Baumhauer R | 2000 | Geoderma2000，96，12： | 1 |
| 9 | Alternative operative exposures of the posterior aspect of the humeral diaphysis with reference to the radial nerve 显示文摘 | Gerwin M Hotchkiss R Weiland A | 1996 | Bone Joint Surg1996，78，11： | 1 |
| 10 | Wholebody Mill and PET-CT in the management of cancer patients 显示文摘 | GERWIN P ALEXANDER R STEFAN O | 2006 | Eur Radiol2006，16，： | 1 |
| 11 | Landscape and ecosystem development after disturbance by mining 显示文摘 | Huttl R F Gerwin W | 2005 | Ecological Engineering2005，24，12： | 1 |
| 12 | Effect of soil parameter on the corrosion of archaeological metal finds 显示文摘 | Gerwin W Baumhauer R | 2000 | Geoderma2000，96，12： | 1 |
| 13 | T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro:the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells显示文摘 | Lyck R Reiss Y Gerwin N Greenwood J | | 0，，10： | 1 |
| 14 | A review of rnyofascial pain and fibromy algia: Factors that promote their persistence显示文摘 | Gerwin R D | 2005 | Acu puncture in Medicine2005，23，3： | 1 |
| 15 | Effect of Soil Parameters on the Corrosionof Archaeological Metal Finds显示文摘 | W Gerwin R Baumhauer | 2000 | Geoderma2000，96，： | 1 |
| 16 | Alternative poera- tire exposures of the posterior aspect of the humeral diaphysis with reference to the radial nerve显示文摘 | Gerwin M Hotchkiss R WeilandAJ | 1996 | J Bone Joint Surg Am1996，78，： | 1 |
| 17 | Effect of soil parameters on the corrosion of archaeological metal finds显示文摘 | GERWIN W BAUMHAUER R | 2000 | Geoderma2000，96，12： | 1 |
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