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| 1 | Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C显示文摘AIM:To evaluate serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C virus(HCV)infection.METHODS:The study included 30 children with chronic HCV infection before receiving antiviral therapy.Chronic HCV infection was defined by positive anti-HCV,a positive polymerase chain reaction for HCV-RNA for more than 6 mo with absence of any associated liver disease.A second group of 30 age-and sex-matched healthy children served as controls.Serum C4a levels were measured by enzyme-linked immunosorbent assay.Liver fibrosis stage and inflammatory grade were assessed using Ishak scoring system.Serum C4a levels were compared according to different clinical,laboratory and histopathological parameters.Statistical significance for quantitative data was tested by MannWhitney U non-parametric tests.For qualitative data,significance between groups was tested by 2test.Correlation was tested by Spearman’s test.Results were considered significant if P value≤0.05.RESULTS:The age of the patients ranged from 3.5to 18 years and that of controls ranged from 4 to 17years.C4a mean levels were merely lower in patients(153.67±18.69 mg/L)than that in the controls(157.25±11.40 mg/L)with no statistical significance(P=0.378).It did not differ significantly in patients with elevated vs those with normal transaminases(152.25±16.62 vs 155.36±21.33;P=0.868)or with different HCV viremia(P=0.561).Furthermore,there was no statistical significant difference in serum levels between those with no/mild fibrosis and those with moderate fibrosis(154.65±20.59 vs 152.97±17.72;P=0.786)or minimal and mild activity(155.1±21.93 vs 152.99±17.43;P=0.809).Though statistically not significant,C4a was highest in fibrosis score 0(F0),decreasing in F1 and F2 to be the lowest in F3.When comparing significant fibrosis(Ishak score≥3)vs other stages,C4a was significantly lower in F3 compared to other fibrosis scores(143.55±2.33 mg/L vs 155.26±19.64 mg/L;P=0.047)and at a cutoff value of less than 144.01 mg/L,C4a could discriminate F3 with 76.9%sensitivity and75%specificity from other stages of fibrosis.CONCLUSION:Serum complement C4a did not correlate with any of transaminases,HCV viremia or with the histopathological scores.Although C4a decreased with higher stages of fibrosis,this change was not significant enough to predict individual stages of fibrosis.Yet,it could predict significant fibrosis with acceptable clinical performance. | Behairy E Behairy Ghada M El-Mashad Ragab S Abd-Elghany Enas M Ghoneim Mostafa M Sira | 2013 | World Journal of Hepatology2013，5，8： | 4 |
| 2 | Comparison of psychologic and cognitive functions after general or regional anesthesia 显示文摘 | Ghoneim M M Hi nrichs JV O'Hara MW | 1988 | Anesthesiology1988，69，4： | 1 |
| 3 | Extended Radical Lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multi center study显示文摘 | Leissner J Ghoneim M A Abol-Enein H | 2004 | J Urol2004，171，： | 1 |
| 4 | Response of a laminar premixed flame to flow oscillations: A kinematic model and thermoacoustic instability results显示文摘 | Fleifil M Annaswamy A M Ghoneim Z A | 1996 | Combustion and Flame1996，106，4： | 1 |
| 5 | Voltammetric studies and assay of the antiiflammatory drug ketoprofen in pharmaceutical formulation and human plasma at a mercury electrode显示文摘 | GHONEIM M M TAWFI K | 2003 | Can J Chem2003，81，： | 1 |
| 6 | Sequence,characterization and localization of a cysteine proteinase cathepsin L in Schistosoma mansoni显示文摘 | Michel A Ghoneim H Resto M | 1995 | Mol Biochem Parasitol1995，73，： | 1 |
| 7 | Tuberculosis in Egyptian kidney trasplant recipients:study of clinical couse and outcome显示文摘 | el-Agroudy A E Refaie A F Moussa O M Ghoneim -M-A | 2003 | J Nephrol2003，16，3： | 1 |
| 8 | Targeting tams-1 gene results in underestimation of Theileria annulata infection in diseased cattle in Egypt显示文摘 | Ghoneim A M EI-Fayomy A O | 2014 | Acta Parasitol2014，59，1： | 1 |
| 9 | Awareness during anesthesia: risk factors, causes and sequelae: a review of reported cases in the literature显示文摘 | Ghoneim MM Block RI Haffarnan M | 2009 | Anesth Analg2009，108，2： | 1 |
| 10 | Awareness during anesthesia: Risk factors, causes and sequelae: A review of report- ed cases in the literature显示文摘 | Ghoneim MM Block R Haffarnan M | 2009 | Anesth Analg2009，108，： | 1 |
| 11 | The trauma of awareness: laistory,clinical features, risk factors, andcost显示文摘 | Ghoneim M | 2010 | Anesth Analg2010，110，3： | 1 |
| 12 | Extracorporeal shock wave lithotripsy in impacted upper ureteral stones: a prospective randomized com- parison between stented and non-stented techniques 显示文摘 | Ghoneim I A EI-Ghoneimy M N E1-Naggar A E | 2010 | Urology2010，75，1： | 1 |
| 13 | Voltammetric and potentiometric studies of some sulpha drug-Schiff base compounds and their metal complexes显示文摘 | GHONEIM M M MABROUK E M HASSANEIN A M | 2007 | Central European Journal of Chemistry2007，5，3： | 1 |
| 14 | , Sequence, characterization and localization of a cysteine proteinase cathepsin L in Schistosoma mansoni显示文摘 | Michel A Ghoneim H Resto M | 1995 | Mol Biochem Parasitol1995，73，12： | 1 |
| 15 | The trauma of awareness:history,clinical features, risk factors 显示文摘 | Ghoneim M | 2010 | Anesth Analg2010，110，3： | 1 |
| 16 | Pressure vessel steels: In- fluence of chemical composition on irradiation sensitivity显示文摘 | Ghoneim M M Hammad F H | 1997 | Int J Press Ves Pip1997，74，3： | 1 |
| 17 | The incidence of awareness during anesthesia: a multicenter United States study显示文摘 | SEBEL P S BOWDLE T A GHONEIM M M | 2004 | Anesth Analg2004，99，3： | 1 |
| 18 | The incidence of awareness during anesthesia:a multicenter United States study显示文摘 | Sebel P Bowdle T Ghoneim M | 2004 | Anesthesia and Analgesia2004，99，： | 1 |
| 19 | Critical evaluation of the problem of chronic urinary retention after orthotopie bladder substitution in women 显示文摘 | ALI-EL-DEIN B GOMHA M GHONEIM MA | 2002 | J Urot2002，168，2： | 1 |
| 20 | A randomized phase Ⅲ study of neoadjuvant chemotherapy for invasive bladder cancer with gemcitabine and cisplatin显示文摘 | Khaled HM Zaqhloul MS Ghoneim M | 2002 | Proc Ann Meet Am Soc Clin Oncol2002，21，： | 1 |
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