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| 1 | Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Ampliflcation(RT-LAMP) on a Chip from Whole Blood显示文摘Viral load measurements are an essential tool for the long-term clinical care of hum an immunodeficiency virus(HIV)-positive individuals. The gol d standards in viral load instrumentation, however, are still too limited by their size, cost, and sophisticated operation for these measurements to be ubiquitous in remote settings with poor healthcare infrastructure, including parts of the world that are disproportionately affected by HIV infection. The challenge of developing a point-of-care platform capable of making viral load more accessible has been frequently approached but no solution has yet emerged that meets the practical requirements of low cost, portability, and ease-of-use. In this paper, we perform reverse-transcription loop-mediated isothermal amplification(RT-LAMP) on minimally processed HIV-spiked whole blood samples with a microfluidic and silicon microchip platform, and perform fluorescence measurements with a consumer smartphone. Our integrated assay shows amplification from as few as three viruses in a ~ 60 nL RTLAMP droplet, corresponding to a whole blood concentration of 670 viruses per μL of whole blood. The technology contains greater power in a digital RT-LAMP approach that could be scaled up for the determination of viral load from a flnger prick of blood in the clinical care of HIV-positive individuals. We demonstrate that all aspects of this viral load approach, from a drop of blood to imaging the RT-LAMP reaction, are compatible with lab-on-a-chip components and mobile instrumentation. | Gregory L.Damhorst Carlos Duarte-Guevara Weili Chen Tanmay Ghonge Brian T.Cunningham Rashid Bashir | 2015 | Engineering2015，1，3： | 8 |
| 2 | Microstructure of c-axis oriented lead titanate thin films by pulsed laser ablation显示文摘 | Ghonge S G Goo E Ramesh R | 1993 | Appl Phys Lett1993，62，15： | 1 |
| 3 | Tube- and ball-like amorphous MoS2prepared by a solvothermal method显示文摘 | Peng Y Meng Z ghong C et at | 2002 | Materials Chemistry and Physics2002，73，： | 1 |
| 4 | Chronic obstructive pulmonary disease in the absence of chronic bronchitis in China 显示文摘 | Lu M Yao W ghong N | 2010 | Respirology2010，15，： | 1 |
| 5 | Studies on liver-protection of Amorpha fruticosa L fruit-extraction显示文摘 | LI KUN DIAO YUNPENG JIAN GHONG | 2006 | China Association of Chinese Medicine2006，24，2： | 1 |
| 6 | Neuropathic pain 显示文摘 | Smith TE Ghong MS | 2000 | Hosp Med2000，42，7： | 1 |
| 7 | Studies on the gas chromatography fingerprint of the volatile oil of fruit in Amorpha fruticosaL显示文摘 | DIAO YUNPENG LI KUN JIAN GHONG | 2005 | China Association Of Chinese Medicine2005，23，11： | 1 |
| 8 | Quantile regression for survival data in modern cancer research:expanding statistical tools for precision medicin显示文摘Quantile regression links the whole distribution of an outcome to the covariates of interest and has become an important alternative to commonly used regression models.However,the presence of censored data such as survival time,often the main endpoint in cancer studies,has hampered the use of quantile regression techniques because of the incompleteness of data.With the advent of the precision medicine era and availability of high throughput data,quantile regression with high-dimensional predictors has attracted much attention and provided added insight compared to traditional regression approaches.This paper provides a practical guide for using quantile regression for right censored outcome data with covariates of low-or highdimensionality.We frame our discussion using a dataset from the Boston Lung Cancer Survivor Cohort,a hospital-based prospective cohort study,with the goals of broadening the scope of cancer research,maximizing the utility of collected data,and offering useful statistical alternatives.We use quantile regression to identify clinical and molecular predictors,for example CpG methylation sites,associated with high-risk lung cancer patients,for example those with short survival. | Hyokyoung GHong David CChristiani Yi Li | 2019 | Precision Clinical Medicine2019，2，2： | 1 |
| 9 | A Survey of Mobile Ad Hoc Network Attacks 显示文摘 | Pradip M Jawandhiya Mangesh M Ghonge M S Ali J S Deshpande | 2010 | International Journal of Engineering Science and Technology (S0975-5462)2010，2，9： | 1 |
| 10 | Zinner syndrome:A unique triad of mesonephric duct abnormalities as an unusual cause of urinary symptoms in late adolescence显示文摘 | Nitin P Ghonge Bharat Aggarwal Amit Kumar Sahu | 2010 | Uroradiology2010，26，3： | 1 |
| 11 | Sirenomelia sequence-report of three cases显示文摘 | aori KB Mitra K Ghonge NP | 2002 | Ind J Radiol Imag2002，12，3： | 1 |
| 12 | CT enterography:state of-the-art CT technique for small bowel imaging显示文摘 | Ghonge NP Aggarwal B Gothi R | | 0，，： | 1 |
| 13 | Carotid athero sclerosis and cognitive function in midlife:the beaver dam offspring study显示文摘 | ghong W Cruickshanks K J Huang G H | 2011 | Atherosclerosis2011，219，1： | 1 |
| 14 | Zinner syn- drome: A unique triad of mesonephric duct abnormalities as an unusual cause of urinary symptoms in late adolescence 显示文摘 | GHONGE NP AGGARWAL I3 SAHU AK | 2010 | Indi- an J Urol2010，26，3： | 1 |
| 15 | Comorbid conditions related to readmissions of Chinese older patients显示文摘To the Editor:China is the most populated country,and it is aging more quickly than almost any other country in the world.According to Worldometer,[1]the population size of China,as of 2020,is around 1.4 billion,with the proportion of the 60-year olds and older being 17.30%in 2017 and expected to reach 35%in 2050.Older age tended to be closely correlated with multimorbidity.Ward and Schiller[2]reported that 65%of men and 72%of women aged>65 years in the US had at least two chronic conditions in 2010.Accordingly,older adults living with multiple chronic conditions tend to be readmitted after discharge,further leading to increased expenditure and more utilization of medical resources.Many studies have reported higher read mission rates in elderly patients.However,previous studies have focused on investigating the factors that influence read mission for a single disease,rather than for the chronic comorbid conditions in the initial hospitalization and the changes in these conditions from initial hospitalization to read mission among the elderly in China.Furthermore,most studies have focused on Caucasian patients and have been conducted in the US.Little is known about Chinese patients due to the lack of large-scale data.Identifying the common chronic comorbid conditions and the changes in these conditions from initial hospitalization to read mission among older people is important as it will help in the understanding of the chronic conditions leading to avoidable read mission and facilitate the development of efficient intervention strategies for the reduction of read missions. | Chunyang Li Hyokyoung GHong Zhiye Ying Xiaoxi Zeng Yi Li | 2022 | Chinese Medical Journal2022，，6： | 0 |
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