|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Study of diffusion and weighted magnetic resonance imaging in human stroke显示文摘 | Gideon A Sindgan B Gihisu P | 1994 | Stroke1994，25，3： | 1 |
| 3 | C-rective protein:a criti-cal update显示文摘 | Mark B Gideon M | 2003 | Clin Invest2003，111，： | 1 |
| 4 | Annual cycle of spawning and molting in the redclaw crayfish Cherax quadricarinatus under laboratory conditions显示文摘 | Tal L Gideon H | 1997 | Aquac1997，157，30： | 1 |
| 5 | Assessing nicotine metabolism inpregnancy-a novel approach using hair analysis显示文摘 | Julia K Phillip B Gideon K | 2004 | Fo-rensic Sci Int2004，145，23： | 1 |
| 6 | Size discrepancy between sonographic and pathological evaluation of solitary papillary thyroid carcinoma显示文摘 | Gideon B Inon B Maya C | 2013 | European Journal of Radiology2013，82，11： | 1 |
| 7 | C-reactive protein:a critical update显示文摘 | Mark b pepys Gideon M Hirschfield | 2003 | J Clin Invest2003，111，： | 1 |
| 8 | Is CEO Pay in High-Technology Finns Related to Innovation? 显示文摘 | Balkin D B Gideon D M Gomez-Mejia L R | 2000 | The Academy of Management Journal2000，43，6： | 1 |
| 9 | Economic development of groundwater in arid zones with applications to the Negev Desert,Israel显示文摘 | Jack B Abraham M Gideon O | 1994 | Management Science1994，40，3： | 1 |
| 10 | Early time course of Nacetylaspartate, creatine and phosphocreatine, and eompounds containhag choline in the brain after acute stroke显示文摘 | Gideon P Henriksen O Sperling B | 1992 | Stroke1992，23，： | 1 |
| 11 | Scheduling jobshops with some identical or similar jobs 显示文摘 | Tami B Michal P Gideon W | 2001 | Journal of Scheduling2001，4，4： | 1 |
| 12 | C-reactive protein: a critical update显示文摘 | Mark B Pepys Gideon M Hirschfield | 2003 | Clin Invest2003，111，12： | 1 |
| 13 | Targeting the PI3K/ Akt/mTOR pathway ~ effective combinations and clinical con- siderations显示文摘 | Jaclyn L Gideon M B Wendy B B | 2008 | Drug Resist Updat2008，11，12： | 1 |
| 14 | A Program for Design in Structural DNA Nanotechnology显示文摘 | J J Birac W B Sherman J Kopatsch P E Constantinou N C Seeman GIDEON | 2006 | J Mol Graphics & Modeling2006，25，： | 1 |
| 15 | IsCEO pay in high-technology firms related to Innova-tion?显示文摘 | Balkin D B Gideon D M Gomez-Mejia L R | 2000 | Academy of Management Journal2000，43，6： | 1 |
| 16 | An intergrated duckweed and algae pond system for nitrogen removal and renovation 显示文摘 | Peter V D S Asher B Gideon O | 1998 | Water Sci Technol1998，38，1： | 1 |
| 17 | Is CEO Pay in High-technology Firms Related to Innovation? 显示文摘 | Balkin David B Markman Gideon D | 2000 | Academy of Management Journal2000，，6： | 1 |
| 18 | Characterization and three-dimensional structures of two dis?tinct bacterial xyloglucanases from families GH5 and GH12显示文摘 | TRACEY M G FARID M I KATHERINE M JENS M E SHIRLEY R JOHAN P T MADS E B PER L J STEFFEN D KATJA S J TORBEN V B KEITH S W HARRY B GIDEON J D | 2007 | Journal of Biological Chemistry2007，282，19： | 1 |
| 19 | Development and testing of a new macro kinetic expression for the iron-based low-temperature Fischer-Tropsch reaction 显示文摘 | BOTES GIDEON F BREMAN B B | 2006 | Ind Eng Chem Res2006，45，22： | 1 |
| 20 | Person Entrepreneurship fit:Why Some People are more Successful as Entrepreneurs than Others 显示文摘 | GIDEON D M ROBERT A B | 2003 | Human Resource Management Review2003，13，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员