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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 3 | Influence of age in estimating maximal oxygen uptake显示文摘ObjectiveTo 在最大的氧举起的估计( EE )的错误上估计年龄的影响( VO 2最大)用性别和在自从估计,测试的周期测力计锻练特定方程的人口, VO 2最大与实质的 EE 被联系,经常超过20%, 18~91 年,可能,由于机械 efficiency.Methods1850 的内在的可变性,成年人(68%人)经历了最大的周期测力计测试的心肺的锻练。心和肺的健康(CRF ) 相对性别和年龄被估计[更年轻(18 ~ 35 年) ,中年(36 ~ 60 年) 并且更旧(>60 年)] 。VO 2 最大[mL·(kg· min )−1] 被对煤气的交换的评价直接测量并且估计了使用性别和人口特定方程。VO 2 最大和相关 EE 在三年龄特定、性特定的 groups.ResultsDirectly 测量的 VO 2 男人和女人的最大是 29.5 ±10.5 mL·(kg· min )−1 和 24.2 ±9.0 mL·(kg· min )−1(P <0.01 ) 。EE [mL·(kg· min ) 为男人和女人的 −1] 和百分比错误(% E ) 有类似的价值, 0.5 ±3.2 和 0.4 ±2.9 mL·(kg· min )−1, 和 − 0.8 ±13.1% 并且 − 1.7 ±15.4%(P >0.05 ) 分别地。分别地,为每个年龄组的 EE 和 % E 为男人:更年轻的 = 1.9 ±4.1 mL·(kg· min )−1 和 3.8 ±10.5% ,中年的 = 0.6 ±3.1 mL·(kg· min )−1 和 0.4 ±10.3% ,更旧的 =− 0.2 ±2.7 mL·(kg· min )−1 和 − 4.2 ±16.6%(P <0.01 ) ;并且为女人:更年轻的 = 1.2 ±3.1 mL·(kg· min )−1 和 2.7 ±10.0% ,中年的 = 0.7 ±2.8 mL·(kg· min )−1 和 0.5 ±11.1% ,更旧的 =-0.8 ±2.3 mL·(kg· min )−1 和 − 9.5 ±22.4%(P <0.01 ).ConclusionVO 2 最大在更年轻的年龄组被低估并且在老年组被过高估计。年龄显著地影响 VO 2 在男人和女人的最大并且当 CRF 用人口被估计时,应该被认为特定方程,而非直接测量了。 | Christina G de Souza Silva Barry A Franklin Daniel E Forman Claudio Gil S Araujo | 2016 | Journal of Geriatric Cardiology2016，13，2： | 2 |
| 4 | Isolation and characterization of abscisic acid-deficient Arabidopsis mutants at two new loci显示文摘 | Leon-Kloosterziel K M Gil M A Ruijs G J | 1996 | Plant J1996，10，： | 1 |
| 5 | Immunotoxic effects of Ochratoxin A in wistar rats after oral administration显示文摘 | A'lvareza L Gil A G Ezpeleta O | 2004 | Food and Chemical Toxicology2004，42，： | 1 |
| 6 | Effects of Pollutants on Laccase Activities of Marasmius Quercophilus, a White-rot Fungus Imlated from a Mediterranean Schlerophyllous Litter 显示文摘 | Famet A M Gil G Ferre E | 2008 | Chemosphere2008，，70： | 1 |
| 7 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 8 | The decrease in plasma ghrelin concentrations following bariatric surgery depends on the functional integrity of the fundus 显示文摘 | Fruhbeck G Diez-Caballero A Gil MJ | 2004 | Obes Surg2004，14，： | 1 |
| 9 | High temperature soldering of SiC particulate aluminium matrix composites (series 2000) using Zn-A1 filler alloys显示文摘 | URENA A GIL L ESCRICHE E SALAZAR J M G ESCALERA M D | 2001 | Science and Technology of Welding and Joining2001，6，1： | 1 |
| 10 | Self-congruity and destinationchoice显示文摘 | Beerli A Meneses G D Gil S M | 2007 | Annals of Tourism Research2007，34，3： | 1 |
| 11 | Gene expression changes induced by Ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration显示文摘 | Arbillaga L Vettorazzi A Gil A G Delft J H García-Jalón J A Cerain A L | 2008 | Toxicology and Applied Pharmacology2008，230，2： | 1 |
| 12 | 显示文摘 | Puente G de la Centeno A Gil A | 1998 | Journal of Colloid and Interface Science1998，202，1： | 1 |
| 13 | Comparative study of six pear cuhivars in terms of their phenolic and vitamin C con- tents and antioxidant capacity 显示文摘 | ANCHEZ A C G GIL-L ZQUIERDO A GIL M I | 2003 | Journal of the Science of Food and Agriculture2003，83，： | 1 |
| 14 | Scaling up ideals to freedom: are densities of red knots across western Europe consistent with ideal free distribution? 显示文摘 | QUAINTENNE G VAN GILS J A BOCHER P | 2011 | Proc Biol Sci2011，278，： | 1 |
| 15 | Models for quantifying the economic benefits of distributed generation显示文摘 | Gil H A Joos G | 2008 | Transactions on Power Systems2008，23，2： | 1 |
| 16 | Evidence of textural modifications of an activated carbon on liquid-phase oxidation treatments显示文摘 | Gil A Puente G D L Grange P | 1997 | Microporous aterials1997，12，13： | 1 |
| 17 | Gene expression changes induced by Ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration显示文摘 | Arbillaga L Vettorazzi A Gil A G Delft J H García-Jalón J A Cerain A L | 2008 | Toxicology and Applied Pharmacology2008，230，2： | 1 |
| 18 | Reactive Power Pricing:a Conceptual Framework for Remuneration and Charging Procedures 显示文摘 | Gil J B Roman Tomas G S Roman J J A | 2000 | IEEE Trans on Power Systems2000，15，2： | 1 |
| 19 | High temperature soldering of SiC particulate aluminum matrix composites (series 2000) using Zn-Al filler alloys显示文摘 | URE?A A GIL L ESCRICHE E de GóMEZ SALAZAR J M ESCALERA M D | | 0，，： | 1 |
| 20 | 2005, Structural and ultrastructural changes on muscle tissue of sea bass, Dicemtrarchus labrax L, after cooking and freezing显示文摘 | Ayala M D Albors O L Blanco A Garcia-Aleazar A Abellan E Zarzosa R G Gil F | 2005 | Aquaculture2005，250，12： | 1 |
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