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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor cells.Among human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and NK2.Using the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone marrow.Pseudotime analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological conditions.Transcriptomic profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell heterogeneity.Bone marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 5 |
| 3 | Linear unequal error protection codes from shorter codes显示文摘 | Wil J Gils V | 1984 | IEEE Transactions on Information Theory1984，30，3： | 1 |
| 4 | Neurites regrowth of cortical neurons by GSK3-beta inhibition independently of Nogoreceptor显示文摘 | Seira O Gavín R Gil V | 2010 | J Neurochem2010，113，6： | 1 |
| 5 | The effect of using PSE meat in the manufacture of dry-cured ham显示文摘 | BANON S GIL M D MARIA-VICTORIA G M V | 1998 | Food Research and Technology1998，206，2： | 1 |
| 6 | Thermal behaviour and kinetics of coal/biomass blends during co-combustion显示文摘 | Gil M V Casal D Pevida C | 2010 | Bioresource Technology2010，101，14： | 1 |
| 7 | Thermal degradation of glu- cosinolates 显示文摘 | Mac Leod A J Panesar S S Gil V | 1981 | Phytochemistry1981，20，5： | 1 |
| 8 | Mitral valve repalaeement in rheumatic patients: effects of chordal preservation 显示文摘 | Garcta-Fuster R Estevez V Gil O | 2008 | Ann Tho- rae Stag2008，86，2： | 1 |
| 9 | Oxy-fuel combustion kinetics and morphology of coal chars obtained in N2 and CO2 atmospheres in an entrained flow reactor显示文摘 | Gil M V Riaza J Alvarez L | 2012 | Applied Energy2012，91，1： | 1 |
| 10 | Evaluation of the effect of mannan-oligosaccharides on the competitive exclusion of Salmonella enteritidis colonization in broiler chicks显示文摘 | Fernandez F Hinton M Gils B V | 2000 | Avian Pathol2000，29，： | 1 |
| 11 | Thermal behavior and kinetics of coal/biomass blends during co- combustion 显示文摘 | GIL M V CASAL D PEVIDA C | 2010 | Bioresource Technology2010，101，14： | 1 |
| 12 | Co-gasification of Different Rank Coals with Biomass and Petroleum Coke in a High-pressure Reactorfor H2-Rich Gas Production显示文摘 | Fermoso J Arias B Gil M V | | 0，，9： | 1 |
| 13 | Adsorption of Cu(II), Cd(II), and Pb(II)from aqueous single metal solutions by cellulose and mercerized cellulose chemically modified with succinic anhydride显示文摘 | GURGEL L V A JNIOR O K DE FREITAS GIL R P | 2008 | Bioresource Technology2008，99，8： | 1 |
| 14 | Studies on acetate ester production by non-Saccharomyces wine yeasts 显示文摘 | Virginia Rojas Jose V Gil Francisco Pinaga et (d | 2001 | International Journal of Food Microbiology2001，70，： | 1 |
| 15 | Response of soil microbial communities to different management practices in surface soils of a soybean agroecosystem in Argentina显示文摘 | Gil S V Meriles J Conforto C | 2011 | European Journal of Soil Biology2011，47，1： | 1 |
| 16 | A study of oxy-coal combustion with steam addition and biomass blending by thermogravimetric analysis显示文摘 | Gil M V Riaza J (A)lvarez L | | 0，，01： | 1 |
| 17 | Effect of oxy-fuel combustion with steam addition on coal ignition and burnout in an entrained flow reactor显示文摘 | Riaza J Alvarez L Gil M V | 2011 | Energy2011，36，8： | 1 |
| 18 | A study of oxy-coal combustion with steam addition and biomass blending by thcrmogravimetric analysis 显示文摘 | Gil M V Riaza J Alvarez L | 2012 | Journal of Thermal Analysis and Calorimetry2012，109，1： | 1 |
| 19 | Correction:Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Correction to:Cellular&Molecular Immunology http://gffzzd3cc09b8251d45dfsx6bupwwv0pfo6fo0.ffgz.tsg.suse.edu.cn/10.1038/S41423-020-00574-8,published online 25 November 2020 In the version of this article initially published,two unintended errors were made during manuscript preparation.(1)The figure legend for Panel 3B was missing;the correct legend is as follows. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 20 | Validity of 6 indirect methods to assess treatment compliance in arterial hypertension显示文摘 | GIL V PINEDA M MARTINEZ JL | 1994 | Med Clin1994，102，14： | 1 |
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