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| 1 | Guidelines on the prevention, dia- gnosis, and treatment of infective endocarditis ( new version 2009) 显示文摘 | GILBERT H BRUNO H | 2009 | Euro Heart J2009，30，19： | 1 |
| 2 | IR sensor design insight from missile plume prediction models显示文摘 | Rapanotti John L Gilbert Bruno Richer Guy | 2002 | SPIE2002，4718，： | 1 |
| 3 | Guidelines onthe prevention,diagnosis,and treatment of infective endocar-ditis(new version 2009)显示文摘 | Gilbert Habib Bruno Hoen Pilar Tornos | 2009 | European Heart Journal2009，30，： | 1 |
| 4 | Guidelines on the prevention, di- agnosis, and treatment of infective endocarditis 显示文摘 | GILBERT H BRUNO H PILAR T | 2009 | Eur Heat J2009，30，19： | 1 |
| 5 | Intrauterine growth retardation leads to a permanent nephron deficit in the rat显示文摘 | Claudie Merlet-Bénichou Thierry Gilbert Martine Muffat-Joly Martine Lelièvre-Pégorier Bruno Leroy | 1994 | Pediatric Nephrology1994，，2： | 1 |
| 6 | Loss of susceptibility as an alternative for nematode resistance显示文摘 | Janice de Almeida Enger Bruno F Gilbert E | 2005 | Current Opinion in Biotechnology2005，16，2： | 1 |
| 7 | Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis显示文摘 | Sébastien Gibot Aurélie Cravoisy Marie-Nathalie Kolopp-Sarda Marie-Christine Béné Gilbert Faure Pierre-Edouard Bollaert Bruno Levy | 2005 | Critical Care Medicine2005，，： | 1 |
| 8 | AB023.Characterization of a novel anti-angiogenic protein for the treatment of exudative age-related macular degeneration显示文摘Background:Age-related macular degeneration(AMD)is a leading cause of blindness in Canada.The exudative(wet)form of AMD accounts for approximately 15%of AMD patients,but is responsible for the majority of severe vision loss associated with the disease.Wet AMD is characterized by choroidal neovascularization,the abnormal growth of blood vessels from the choroid into the sub-retinal space.Current therapies for exudative AMD directly target and inhibit the vascular endothelial growth factor(VEGF)signaling pathway,a signaling axis that promotes endothelial cell survival.While initially effective at restoring visual acuity,recent studies suggest that chronic use of anti-VEGF therapies can lead to further vision impairment through off-target effects on photoreceptors and other non-vascular tissues.These off-target effects of anti-VEGF therapy highlights the need for alternative treatments for this increasingly common disease.We have recently identified a novel anti-angiogenic protein,AAP1 that inhibits retinal angiogenesis during development.As a regulator of the vasculature,our current work aims to characterize the function of AAP1 in endothelial cells and determine the potential of AAP1 as a therapy for exudative AMD.Methods:To address our aims,we used various in vivo and in vitro models of normal and pathological vascular growth.Mice were injected intravitreally with AAP1 to investigate its effects on developmental and pathological angiogenesis.Using HUVECs,we employed immunofluorescent quantifications to determine the impact of AAP1 on sprouting angiogenesis by measuring cellular proliferation,apoptosis and migration.To investigate the signaling events that mediate the actions of AAP1,we examined key signaling pathways involved in angiogenesis by western blotting and qPCR.Results:We evaluated the role of AAP1 as a regulator of angiogenesis during retinal development and mouse models of AMD.Our pilot data show that AAP1 prevents angiogenesis in vitro and in vivo,and that it can also inhibit pathological neovascularization in experimental models of AMD.In spite of its anti-angiogenic effects,our data show that AAP1 does not adversely affect photoreceptors.Both in vitro and in vivo systems showed a decrease in cellular division,while apoptosis was not affected in response to AAP1 treatment.While cellular migration was reduced in AAP1-treated HUVECs,cellular polarity was not affected.Finally,gene and protein expression of key angiogenic factors were modified in response to AAP1.Conclusions:AAP1 is a potent regulator of angiogenesis.However,in contrast to anti-VEGF agents,our data suggests that AAP1 does not adversely affect the photoreceptors-highlighting the therapeutic potential of this protein.Further data generated from our studies characterizing the mechanism of AAP1 action may lead to a novel treatment option for AMD patients preventing vision loss and improving their quality of life. | Erika Hooker Natalija Popovic Andrea Barabino Anthony Flamier Gilbert Bernier Bruno Larrivée | 2018 | Annals of Eye Science2018，，1： | 0 |
| 9 | 多相流测量新技术显示文摘一种新的地面流量计从根本上改变了我们测量生产井复杂流动的方式。这种新技术引发的改变使我们能准确测量三相流体中的快速变化,包括以前很难定量测量的段塞流、泡状流和稳定乳状液流等。实时测量多相流提高了作业效率,节省了时间和费用。 | Ian Atkinson Bertrand Theuveny Michel Berard Gilbert Conort Trey Lowe Allan McDiarmid Parviz Mehdizadeh Bruno Pinguet Gerald Smith Kerry J.Willimnson | 2005 | 国外测井技术2005，20，6： | 0 |
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