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| 1 | Role of laryngeal mask airway in laparoscopic cholecystectomy显示文摘Laparoscopic cholecystectomy is one of the most commonly performed surgical procedures and the laryngeal mask airway(LMA) is the most common supraglottic airway device used by the anesthesiologists to manage airway during general anesthesia. Use of LMA has some advantages when compared to endotracheal intubation, such as quick and ease of placement, a lesser requirement for neuromuscular blockade and a lower incidence of postoperative morbididy. However, the use of the LMA in laparoscopy is controversial, based on a concern about increased risk of regurgitation and pulmonary aspiration. The ability of these devices to provide optimal ventilation during laparoscopic procedures has been also questioned. The most important parameter to secure an adequate ventilation and oxygenation for the LMA under pneumoperitoneum condition is its seal pressure of airway. A good sealing pressure, not only state correct patient ventilation, but it reduces the potential risk of aspiration due to the better seal of airway. In addition, the LMAs incorporating a gastric access, permitting a safe anesthesia based on these commented points. We did a literature search to clarify if the use of LMA in preference to intubation provides inadequate ventilation or increase the risk of aspiration in patients undergoing laparoscopic cholecystectomy. We found evidence stating that LMA with drain channel achieves adequate ventilation for these procedures. Limited evidence was found to consider these devices completely safe against aspiration. However, we observed that the incidence of regurgitation and aspiration associated with the use of the LMA in laparoscopic surgery is very low. | José M Belena Ernesto Josué Ochoa Mónica Núnez Carlos Gilsanz Alfonso Vidal | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 4 |
| 2 | A half century (1961-2011) of applying microsurgery to experimental liver research显示文摘The development of microsurgery has been dependent on experimental animals. Microsurgery could be a very valuable technique to improve experimental models of liver diseases. Microdissection and microsutures are the two main microsurgical techniques that can be considered for classifying the experimental models developed for liver research in the rat. Partial portal vein ligation, extrahepatic cholestasis and hepatectomies are all models based on microdissection. On the other hand, in portacaval shunts, orthotopic liver transplantation and partial heterotopic liver transplantation, the microsuture techniques stand out. By reducing surgical complications, these microsurgical techniques allow for improving the resulting experimental models. If good experimental models for liver research are successfully developed, the results obtained from their study might be particularly useful in patients with liver disease. Therefore experimental liver microsurgery could be an invaluable way to translate laboratory data on liver research into new clinical diagnostic and therapeutic strategies. | Maria-Angeles Aller Natalia Arias Isabel Prieto Salvador Agudo Carlos Gilsanz Laureano Lorente Jorge-Luis Arias Jaime Arias | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 3 | Efficacy of bevacizumab-containing chemotherapy in metastatic colorectal cancer and CXCL5 expression: Six case reports显示文摘BACKGROUND In metastatic colorectal cancer(mCRC),the anti-vascular endothelial growth factor drug bevacizumab(BVZ)plus chemotherapy significantly improves progression-free survival compared to chemotherapy(CT)alone.This benefit is not,however,observed in all patients.While increased chemokine CXCL5 gene expression promoting angiogenesis has been proposed as a prognostic mCRC biomarker,few studies have examined its relationship with drug efficacy.This study sought to analyze tumor CXCL5 gene expression in six patients with different efficacy of BVZ-containing CT in terms of the tumor response to treatment.CASE SUMMARY We report six cases of stage IV KRAS-mutated mCRC.Patients were given first line treatment with BVZ-containing chemotherapy in University Hospital of Fuenlabrada.The six patients differed in terms of primary tumor location(right/left side),tumor burden(mostly hepatic and peritoneal disease)and clinical disease course.Before treatment onset,total RNA was isolated from paraffinated tumor biopsy specimens and CXCL5 gene expression quantified through conventional RT-qPCR procedures.Our main finding was that CXCL5 expression levels were several times higher in three patients with lower progression free survival(under 6 mo)from the start of treatment.CONCLUSION A higher expression of CXCL5 was observed in the three patients showing worse tumor response to treatment. | Apolonia Novillo María Gaibar Alicia Romero-Lorca María Fuencisla Gilsanz Laura Beltrán Miguel Galán Beatriz Antón Diego Malón Amalia Moreno Ana Fernández-Santander | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 4 | Conventional slepwise VS vital capacity rapid inhalation indunction at two concentrations of sevoflurane 显示文摘 | MARTIN LR GILSANZ F JODRIGO J | 2004 | Eur J Anaesthesiol2004，21，： | 1 |
| 5 | Life-threatening nonsphero- cytic hemolytic anemia in a patient with a null mutation in the PKLR gene and no compensatory PKM gene expression 显示文摘 | Diez A Gilsanz F Martinez J | 2005 | Blood2005，106，5： | 1 |
| 6 | Prevalence of incidental paranasal sinuses opacification in pediatric patients:a CT study显示文摘 | DIAMENT M J SENAC M O J R GILSANZ V | 1987 | J Comput Assist Tomogr1987，，6： | 1 |
| 7 | Vertebral size in elderly women with osteoporosis显示文摘 | Gilsanz V Loro ML Roe TF | 1995 | J Clin Invest1995，95，5： | 1 |
| 8 | Premature carotid artery disease in pediatric cancer survivors treated with neck irradiation显示文摘 | Meeske KA Siegel SE Gilsanz V | 2009 | Pediatr Blood Cancer2009，53，： | 1 |
| 9 | The longitudinal effects ofphysical activity and dietary calcium on bone mass accrual across stagesof pubertal development 显示文摘 | Lappe JM Watson P Gilsanz V | 2015 | J Bone Miner R es2015，30，1： | 1 |
| 10 | G6PD deficiency : the genotype-phenotype association显示文摘 | Mason PJ Bautista JM Gilsanz F | 2007 | Blood Rev2007，21，5： | 1 |
| 11 | Comparison of epidural analgesia with combined spinal-epidural analgesia for labor:a retrospective study of6497Cases显示文摘 | Miro M Guasch E Gilsanz F | 2008 | Int J Obstet Anesth2008，，17： | 1 |
| 12 | Conventional stepwise vs vital capacity rapid inhalation induction at two concentra- tion of sevoflurane 显示文摘 | Martin LR Gilsanz F Rodrigo J | 2004 | Eur J Anaesthesiol2004，21，4： | 1 |
| 13 | Bone Acquisition in Healthy Young Females Is Reciprocally Related to Marrow Adiposity显示文摘 | Natascia Di Iorgi Ashley O. Mo Kate Grimm Tishya A. L. Wren Frederick Dorey Vicente Gilsanz | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，6： | 1 |
| 14 | 显示文摘 | Gilsanz V | 1998 | Clin Endocrinol Metab1998，83，11： | 1 |
| 15 | A Methodology for the Evaluation of Water Policies in European显示文摘 | Lucia De Stefano Javier de Pedraza Gilsanz Fermín Villarroya Gil | | 0，，45： | 1 |
| 16 | Cord blood megakaryoeytes do not complete maturation, as indicated by impaired establishment of endomitosis and low expression of G1/S cyclins upon thrombopoietin-induced differentiation显示文摘 | Bomstein R Jose GV Gilsanz F | 2001 | Br J Haematol2001，114，2： | 1 |
| 17 | Reciprocal Relation between Marrow Adiposity and the Amount of Bone in the Axial and Appendicular Skeleton of Young Adults显示文摘 | Natascia Di Iorgi Michael Rosol Steven D. Mittelman Vicente Gilsanz | 2008 | The Journal of Clinical Endocrinology & Metabolism2008，，6： | 1 |
| 18 | Reciprocal relations of subcutaneous and visceral fat to bone structure and strength 显示文摘 | Gilsanz V Chalfant J Mo AO | 2009 | J Clin Endocrinol Metab2009，94，： | 1 |
| 19 | Conventional stepwise vslvital capacity rapid inhalation induction at two concentrations of sevoflurane显示文摘 | Martin LR Gilsanz F Rodrigo J | 2004 | Eur J Anaesthesiol2004，21，4： | 1 |
| 20 | Reciprocal relations of subcu- taneous and visceral fat to bone structure and strength 显示文摘 | Gilsanz V Chalfant J Mo AO | 2009 | J Clin Endocrinol Metab2009，94，9： | 1 |
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