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| 1 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 2 | Does corporate governance matter in competitive industries?显示文摘 | Xavier Giroud Holger M. Mueller | 2009 | Journal of Financial Economics2009，，3： | 4 |
| 3 | Association Between Diabetes and Stroke Subtype on Survival and Functional Outcome 3 Months After Stroke: Data From the European BIOMED Stroke Project显示文摘 | Salah-Eddine Megherbi Chantal Milan Dominique Minier Grégory Couvreur Guy-Victor Osseby Kate Tilling Antonio Di Carlo Domenico Inzitari Charles D.A. Wolfe Thibault Moreau Maurice Giroud | 2003 | Stroke: Journal of the American Heart Association2003，，3： | 3 |
| 4 | Stabilityof geosynthetic-soil layered systems on slope 显示文摘 | Giroud J P Williams N D Peite T Beech J F | 1995 | Gepsynthetics International1995，2，6： | 2 |
| 5 | 2C-B:A new psychoactive phenylethylamine recently discovered in ecstasy tablets sold on the swiss black market 显示文摘 | Giroud C Augsburger M L Rivier P | 1998 | J Anal Toxicol1998，22，5： | 1 |
| 6 | Characterization of honey amino acid profiles using high-pressure liquid chromatography to control authenticity 显示文摘 | Cotte J F Casabianica H Giroud B | 2004 | Anal Bioanal Chem2004，378，： | 1 |
| 7 | Rate of leakage through a composite liner due to geomembrane defects 显示文摘 | Giroud J P Badu-Tweneboah K Bonaparte R | 1992 | Geotextiles and Geomembranes1992，11，： | 1 |
| 8 | Role of associated cortical lesions in motor partial seitures and lenticulostriate infarcts显示文摘 | Dumas R | 1995 | Epilepsia1995，36，： | 1 |
| 9 | Design of soil layer-geosynthetic systems overlying voids显示文摘 | Giroud J P Bonaparte R Beech J F | 1990 | Geotextiles and Geomembranes1990，9，： | 1 |
| 10 | Leakage through liners constructed with geomembranes,Part I: Geomembrane liners 显示文摘 | Giroud J P Bonaparte R | 1989 | Geotextiles and Geomembranes1989，8，： | 1 |
| 11 | N-acetylasparrate:a literature review of animal research on brain ischmlia显示文摘 | Demougeot C Marie C Giroud M | 2004 | J Neurochem2004，90，4： | 1 |
| 12 | Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography显示文摘 | Giroud D Li JM Urban P | 1992 | Am J Cardiol1992，69，： | 1 |
| 13 | Corporate governance,product market competition,and equity prices显示文摘 | GIROUD X MUELLER H M | 2011 | Journal of Finance2011，66，2： | 1 |
| 14 | New methods for the direct determination of dissolved inorganic,organic and total carbon in natural waters by reagent-free ion chromatography and inductively coupled plasma atomic emission spectrometry显示文摘 | GUNNARSSON I GIROUD N STEFANSSON A | 2007 | Anal Chim Acta2007，582，1： | 1 |
| 15 | Design of soil layergeosynthetic systems overlying voids显示文摘 | Giroud J P Bonaparte R Gross B A | 1990 | Geotextiles and Geomembranes1990，9，1： | 1 |
| 16 | Characterization of honey amino acid profiles using high-pressure liquid chromatography to control authenticity显示文摘 | Cotte J F Casabianica H Giroud B | 2004 | Analytical and Bioanalytic Chemistry2004，378，： | 1 |
| 17 | Reduced brain N-acetylaspartate in frontal lobes suggests neuronal loss in patients with amyotrophic lateral sclerosis显示文摘 | Giroud M Walker P Bernald D | 1996 | Neurol Res1996，18，3： | 1 |
| 18 | MNE linkages in in-ternational business:a framework for analysis显示文摘 | Giroud Axèle Scott-Kennel Joanna | 2009 | Interna-tional Business Review2009，18，6： | 1 |
| 19 | Mathematical model of geomembrane stress-strain curves with a yield peak 显示文摘 | GIROUD J P | 1994 | Geotextiles andGeomembranes1994，13，1： | 1 |
| 20 | Evolution of strategies for management of the patent arterial duct 显示文摘 | Giroud JM Jacobs JP | 2007 | Cardiol Young2007，17，2： | 1 |
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