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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | Clinical benefit of enoxaparin in patients with high - risk acute coronary syndromes without ST ele- vations in clinical practice 显示文摘 | Zeymer U Gitt A Jtinger C | 2006 | Am J Cardiol2006，98，1： | 1 |
| 3 | Lung function and exercise gas exchange in chronic heart failure显示文摘 | Wasserman K Zhang YY Gitt A | 1997 | Circulation1997，96，7： | 1 |
| 4 | Incidence, determinants, and clinical course of reinfarction in-hospital after index acute myocar- dial infarction ( results from the pooled data of the maximal individ- ual therapy in acute myocardial infarction ,and the myo- cardial infarction registry ) 显示文摘 | Dtnges K Schiele R Gitt A | 2001 | Am J Cardiol2001，87，9： | 1 |
| 5 | Galectins:structure and function of a large family of animal lectins 显示文摘 | Barondes S H Cooper D N Gitt M A | 1994 | J Biol Chem1994，269，20： | 1 |
| 6 | Efficacy and safety of enoxaparin in combination with and without GPIIb/IIIa inhibitors in unselected patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention 显示文摘 | Zeymer U Gitt A Zahn R | 2009 | Eurolntervention2009，4，4： | 1 |
| 7 | Lung function and exercise gas exchange in chronic heart failure显示文摘 | Wasserman K Zhang YY Gitt A | 1997 | Circulation1997，96，： | 1 |
| 8 | Galectins, structure and function of a large family of animal lectins显示文摘 | BARONDES S H COOPER D N GITT M A | 1994 | J Biol Chem1994，269，20： | 1 |
| 9 | Cardiopulmonary capacity in patients with coronary heart disease显示文摘 | Winter U J Gitt A K Blaum M | 1994 | Zeitschrift für Kardiologie1994，，： | 1 |
| 10 | Incidence,determinants, and clinical course of reinfarctionin-hospital after index acute myocardial infarction (resultsfrom the pooled data of the maximal individual therapy inacute myocardial infarction , and the myocardialinfarction registry )显示文摘 | Donges K Schiele R Gitt A | 2001 | Am J Cardiol2001，87，9： | 1 |
| 11 | Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC显示文摘 | Augusto Caraceni Geoffrey Hanks Stein Kaasa Michael I Ben- nett Cirmia Brunelli Nathan Chemy Ola Dale Franco De Conno Marie Fallon Magdi Hanna Dagny Faksvfig Haugen Gitte Juhl Samuel King PadKlepstad Eivor A Laugsand Marco Maltoni Se- bastiano Mercadante Maria Nabal Alessandra Pigni Lukas Rad- bmch Colette Reid Per Sjogren Patrick C Stone Davide Tassi- nail Giovambattista Zeppetella | 2012 | Lancet Oncol2012，13，2： | 1 |
| 12 | Simulation of the evolution of GP zones in Al - Cu alloys: an extended Cahn - Hilliard approach 显示文摘 | Lochte L Gitt A Gottstein G I | 2000 | Acta Metall2000，48，11： | 1 |
| 13 | Association testing of novel type 2 dia- betes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THA- DA,ADAMTS9,, and NOTCH2 loci with insulin release, insulin sensi- tivity,and obesity in a population-based sample of 4,516 glucose-toler- ant middle-aged Danes显示文摘 | Niels G Gitte A Nikolaj T | 2008 | Diabetes2008，57，： | 1 |
| 14 | Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death显示文摘 | Gitt A Wasserman K Kilkowski C | 2002 | Circulation2002，106，： | 1 |
| 15 | Incidence,determinants,and clinical course of reinfarction in-hospital after index acute myocardial infa rction (results from the pooled data of the maximal individual therapy in acute myocardial infarction[MITRA],and the myocardial infarction regist ry[M显示文摘 | D(O)NGES K SCHIELE R GITT A WIENBERGEN H | | 0，，09： | 1 |
| 16 | I-Iypoglycaemia is more frequent in type 2 diabetic patients with co-morbld vasculardisease: an analysis of the DiaRegis registry 显示文摘 | Gitt A K Bramlage P Binz C | 2012 | Eur J Cardiovasc Prey Rehabil2012，19，4： | 1 |
| 17 | Incidence, determinants, and clinical course of reinfarction in-hospital after index acute myocardial infarction ( results from the pooled data of the maximal individual therapy in acute myocardial infarction, and the myocardial infarction registry ) 显示文摘 | Donges K Schiele R Gitt A | 2001 | Am J Cardiol2001，87，： | 1 |
| 18 | EuroHeart score for the evaluation of in-hospital mortality in patients undergoing percutaneous coronary intervention显示文摘 | de Mulder M Gitt A van Domburg R | 2011 | Eur Heart J2011，32，11： | 1 |
| 19 | Bacterial Resistance Levels in Danish Farmland as a Result of Treatment With Pig Manure Slurry显示文摘 | GITTE S YVONN A BENT H S | 2003 | Environment International2003，28，7： | 1 |
| 20 | Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies显示文摘 | WIENBERGEN H GITT A K SCHIELE R | 2003 | Am J Cardiol2003，92，： | 1 |
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