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| 1 | Erectile dysfunction and central obesity: an Italian perspective显示文摘可勃起的机能障碍(编辑) 是肥胖的经常的复杂并发症。这评论的目的是极其分析肥胖和编辑的框架,把在二个病理学的实体之间的连接。当前的临床的证据显示出那肥胖,和特别地中央的肥胖,与两个 arteriogenic 版本被联系并且减少了睾丸激素(T) 层次。联系肥胖的性腺机能减退和增加的心血管的风险可能部分在超重、肥胖的个人认为编辑的更高的流行正当,是想得到的。相反地,与肥胖有关的心理骚乱不似乎然而在肥胖相关的编辑的致病起一个主要作用,在编辑之间的协会和内脏的胖累积从已知的联系肥胖的 comorbidities 是独立的临床、现出症状之前的潜的数据表演。因此,内脏的脂肪怎么能损害阴茎 microcirculation,仍然保持未知。自从在编辑题目的中央肥胖在高心血管的风险分类个人,这个点是特别地相关的,特别在最年轻的。在肥胖的题目的编辑的存在可能在说服他们开始一个善良的周期帮助保健专业人员,在性机能障碍的修正将是为改进生活方式行为的报酬的地方。Unsatisfying 性活动为请教接着,应该利用机会鼓励肥胖的病人对待的保健专业版代表有意义的、直接动机,除编辑以外,内在的相反的条件,这样不仅恢复可勃起的功能,而且全面健康。 | Giovanni Corona Giulia Rastrelli Sandra Filippi Linda Vignozzi Edoardo Mannucci Mario Maggi | 2014 | Asian Journal of Andrology2014，16，4： | 9 |
| 2 | Treatment of peri-anal fistula in Crohn's disease显示文摘Anal fistulas are a common manifestation of Crohn's disease(CD). The first manifestation of the disease is often in the peri-anal region, which can occur years before a diagnosis, particularly in CD affecting the colon and rectum. The treatment of peri-anal fistulas is difficult and always multidisciplinary. The European guidelines recommend combined surgical and medical treatment with biologic drugs to achieve best results. Several different surgical techniques are currently em-ployed. However, at the moment, none of these tech-niques appear superior to the others in terms of healing rate. Surgery is always indicated to treat symptomatic, simple, low intersphincteric fistulas refractory to medi-cal therapy and those causing disabling symptoms. Ut-most attention should be paid to correcting the balance between eradication of the fistula and the preservationof fecal continence. | Giuseppe S Sica Sara Di Carlo Giorgia Tema Fabrizio Montagnese Giovanna Del Vecchio Blanco Valeria Fiaschetti Giulia Maggi Livia Biancone | 2014 | World Journal of Gastroenterology2014，20，37： | 8 |
| 3 | How to recognize late-onset hypogonadism in men wit sexual dysfunction显示文摘迟了发作的性腺机能减退(LOH ) 在 100 个人与约 1 的流行被认为男性腺机能减退的最普通的形式。LOH 的诊断应该与不含糊地低的浆液睾丸激素(T) 层次在征兆的人被做。然而,因为它被与生理的变老做微分诊断的 nonspecific 症状描绘,它的临床的演讲经常暗中为害、困难认出有问题。性机能障碍是为医药会诊和与低 T 联系的最特定的症状的最重要的决定因素。我们因此分析了出席了我们的单位的 1734 个题目的一个连续系列因为调查在低 T (不同阀值) 之间的协会的性机能障碍,性参数,病历数据(推迟的发身,垂体疾病或 cryptorchidism ) 和他们的物理考试结果。新陈代谢的参数,特别地腰圆周,在检测低 T 显示最大的精确性。我们发现仅仅几症状和符号的协会能显著地提起低 T 的临床的怀疑。结构化的库存,一起聚类性腺机能减退的症状和症状,能帮助临床医生怀疑雄激素缺乏。特别地,组织了会见,例如 ANDROTEST,被表明了有更大的精确性什么时候在检测低 T 与自我相比报导了问询表,铺平。 | Giovanni Corona Giulia Rastrelli Linda Vignozzi Edoardo Mannucci Mario Maggi | 2012 | Asian Journal of Andrology2012，14，2： | 3 |
| 4 | Testosterone therapy: a friend or a foe for the aging men with benign prostatic hyperplasia?显示文摘One of the major concerns for the prescription of medications containing testosterone(T)in the aging men with T deficiency(TD)is prostate disorders(such as benign prostatic hyperplasia,BPH)and their related symptoms(lower urinary tract symptoms,LUTS).This is because prostate is an androgen-responsive gland;however,the androgen dependence of prostate growth,well demonstrated in earlier phases of life,has no clear evidence in late adulthood and senescence.In fact,after the age of 40 years,BPH becomes increasingly more prevalent.On the other hand,in men older than 40 year,a progressive decline in T is observed.These epidemiological data are a starting point for questioning a putative detrimental role of T on the prostate health in the ageing man. | Giulia Rastrelli Linda Vignozzi Mario Maggi | 2020 | Asian Journal of Andrology2020，22，3： | 1 |
| 5 | 前列腺增大与性功能障碍的临床相关性显示文摘前列腺直肠指检可以为了解前列腺的生长状态和发现可疑的外周结节提供有用的信息。本实验的目的在于研究经直肠指检发现前列腺增大与性功能障碍(SD)的临床和生化相关性。对一组2379例患者进行回顾性分析。样本(n=1823;平均年龄为54.7±11.4岁)选自无明显前列腺疾病的人群。对几个指标进行了研究。经过校正后,经直肠指检发现的前列腺增大与代谢终合症(HR=1.346[1.129.1.759];P=0.030)、二型糖尿病(HR=I.489[1.120.1.980];P=0.006)、低密度脂蛋白胆固醇增高(〉100mgdl^-1;HR=1.354[1.018—1.801];P=0.037)及平均血压增高(HR=1.017n.007.1.027]每增加1mmHg;P=0.001)的高发病存在相关性。因此,前列腺增大也与动脉性勃起功能障碍及其他的男科疾病的高发病相关,如精索静脉曲张和早泄。在前列腺增大的人群中PSA水平显著高于非前列腺增大的人群(HR=3-318[2.304;4.799]每增加1单位PSA;P〈0.0001)。根据不同标准,动脉性ED也与PSA水平升高相关。结论:我们的研究结果表明对于ED患者,进行前列腺大小的检查,包括临床(DRE)和生化(PSA)检查是必要的,以此能对患者的性功能障碍和代谢及心血管背景有全面的了解。 | Giovanni Corona Mauro Gacci Elisa Maseroli Giulia Rastrelli Linda Vignozzi Alessandra Sforza Gianni Forti Edoardo Mannucci Mario Maggi | 2014 | Asian Journal of Andrology2014，16，5： | 1 |
| 6 | Both comorbidity burden and low testosterone can explain symptoms and signs of testosterone deficiency in men consulting for sexual dysfunction显示文摘Low testosterone(T)is frequent in men with chronic illnesses.The clinical features of T deficiency(TD)overlap with those of chronic diseases.The aim of this study is to evaluate the relative contribution of chronic disease score(CDS)and low T to the presenee of TD symptoms.A consecutive series of 3862 men(aged 52.1±13.1 years)consulting for sexual dysfunction were studied.Several clinical and biochemical parameters were collected,in eluding the structured interview,ANDROTEST,for the assessme nt of TD symptoms.Penile color Doppler ultrasound(PCDU)was also performed.Based on the medications taken,the CDS was calculated.For a subset of 1687 men,information on mortality was collected(follow-up of 4.3±2.6 years).Higher CDS was associated with lower free and total T(TT)as well as with higher ANDROTEST score.When introducing CDS and TT in multivariable models adjusted for age,severe erectile dysfunctio n and impaired morning erectio ns were associated with both CDS(odds ratio and 95%confide nee interaval,OR[95%Cl]=1.25[1.13;1.37]and 1.38[1.29;1.48],respectively)and low TT(OR[95%Cl]=1.11[1.00;1.23]and 1.13[1.06;1.21],respectively).Similar results were obtained for PCDU parameters.Hypoactive sexual desire was associated with low TT(OR[95%Cl]=1.21[1.13;1.30]),whereas it was inversely related with CDS(OR[95%Cl]=0.91[0.84;0.97]).When considering mortality for major cardiovascular events,TT<8 nmol I1,but not CDS,was a significant predictor(hazard ratio[95%Cl]=5.57[1.51;20.63]).Chronic illnesses are associated with an overt TD.Both chronic diseases and low T can be invoIved in determining symptoms present in subjects complaining for sexual dysfunction.This should be considered in the diagnostic workup for TD. | Giulia Rastrelli Giovanni Corona Mario Maggi | 2020 | Asian Journal of Andrology2020，22，3： | 0 |
| 7 | Relation between skeletal muscle volume and prognosis in rectal cancer patients undergoing neoadjuvant therapy显示文摘The prognostic role of body composition indexes,and specifically sarcopenia,has recently been explored in different cancer types.However,conflicting results have been reported.Heterogeneity in cancer type,cancer stage or oncological treatments,as well as different methodology and definition of sarcopenia,could be accounted for different conclusions retrieved from literature.When focusing on colorectal cancer,it clearly appears that colon and rectal cancers are often treated as a single entity though they have different behaviors and treatments.Particularly,patients with advanced rectal cancer represent a peculiar group of patients that according to current guidelines are treated with neoadjuvant chemotherapy and radiotherapy followed by radical surgery.This review was restricted to a homogeneous group of patients with advanced lower rectal cancer and the aim of exploring whether there is a correlation between skeletal muscle depletion and prognosis.Literature was searched for articles related to patients with advanced rectal cancer undergoing neoadjuvant chemo-radiotherapy(NCRT)followed by radical surgery,in whom muscle mass and/or change in muscle mass during neoadjuvant treatment were measured.Eight full-text articles were selected and included in the present review.The main findings of our review were:(1)The majority of the studies defined sarcopenia as muscle mass alone over muscle strength or physical performance;(2)There was a great deal of heterogeneity in the definition and measures of sarcopenia,in the definition of cut-off values,and in the method to measure change in muscle mass;(3)There was not full agreement on the association between sarcopenia at baseline and/or after chemoradiotherapy and prognosis,and only few studies found a significance in the multivariate analysis;and(4)It seems that a loss in skeletal muscle mass during NCRT is associated with the worst outcomes in terms of disease-free survival.In conclusion,analysis of muscle mass might provide prognostic information on patients with rectal cancer,however more robust evidence is needed to define the role of muscle depletion and/or muscle change during neoadjuvant treatments,related to this specific group of patients.If a prognostic role would be confirmed by future studies,the role of preoperative intervention aimed at modifying muscle mass could be explored in order to improve outcomes. | Paola De Nardi Alessandro Giani Giulia Maggi Marco Braga | 2022 | World Journal of Gastrointestinal Oncology2022，14，2： | 0 |
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