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| 1 | Inflammatory bowel disease:Epidemiology,pathology and risk factors for hypercoagulability显示文摘Hypercoagulability observed in patients with inflammatory bowel diseases(IBD)may lead to thromboembolic events(TE),which affect the venous and arterial systems alike and are an important factor in patients’morbidity and mortality.The risk of TE in IBD patients has been demonstrated to be approximately threefold higher as compared to the general population.The pathogenesis of thrombosis in IBD patients is multifactorial and not fully explained.The most commonly listed factors include genetic and immune abnormalities,disequilibrium between procoagulant and anticoagulant factors,although recently,the role of endothelial damage as an IBD-triggering factor is underlined.Several studies report that the levels of some coagulation enzymes,including fibrinogen,factorsⅤ,Ⅶ,Ⅷ,active factorⅪ,tissue factor,prothrombin fragment 1+2and the thrombin-antithrombin complex,are altered in IBD patients.It has been demonstrated that there is a significant decrease of tissue plasminogen activator level,a marked increase of plasminogen activator inhibitor type 1 and thrombin-activable fibrinolysis inhibitor,a significantly lower level of antithrombinⅢand tissue factor pathway inhibitor.IBD patients have been also observed to produce an increased amount of various anticoagulant antibodies.Hyperhomocysteinemia,which is a potential risk factor for TE was also observed in some IBD patients.Further studies are necessary to assess the role of coagulation abnormalities in IBD etiology and to determine indications for thromboprophylactic treatment in patients at high risk of developing TE. | Danuta Owczarek Dorota Cibor Mikolaj K Glowacki Tomasz Rodacki Tomasz Mach | 2014 | World Journal of Gastroenterology2014，20，1： | 16 |
| 2 | WNT激活剂促进人骨髓基质干细胞向软骨细胞分化的研究显示文摘目的 观察WNT激活剂SB-216763是否具有促进人骨髓基质干细胞(hMSCs)向软骨细胞分化的功能.方法 6例hMSCs,将成软骨细胞诱导分化的hMSCs与SB-216763共同培养,光镜下计数Alcian blue染色阳性的软骨岛的数目、以Alcian blue染色法定量检测由hMSCs分化而来的软骨细胞分泌硫酸化糖胺聚糖的能力,以逆转录-聚合酶链反应(RT-PCR)检测软骨细胞标志基因SOX9、Collagen Ⅱ、Aggrecan的表达变化.结果 在hMSCs成软骨诱导分化过程中,SB-216763可以显著增加软骨岛的数目(133.17±16.58比9.67±1.87,P〈0.01),显著增加hMSCs分化的软骨细胞分泌硫酸化糖胺聚糖的量(1.6~2.6倍,P〈0.01),并促进SOX9、Collagen Ⅱ和Aggrecan基因的表达.结论 SB-216763可以促进体外hMSCs向软骨细胞的分化和成熟. | 沈龙祥 周栓虎 Julie Glowacki | 2010 | 中华实验外科杂志2010，27，2： | 5 |
| 3 | IL28B polymorphism as a predictor of antiviral response in chronic hepatitis C显示文摘AIM:To evaluate the effect of single nucleotide polymorphisms of interleukin(IL)-28B,rs12979860 on progression and treatment response in chronic hepatitis C.METHODS:Patients(n = 64;37 men,27 women;mean age,44 ± 12 years) with chronic hepatitis C,genotype 1,received treatment with peg-interferon plus ribavirin.Genotyping of rs12979860 was performed on peripheral blood DNA.Histopathological assessment of necroinflammatory grade and fibrosis stage were scored using the METAVIR system on a liver biopsy sample before treatment.Serum viral load,aminotransferase activity,and insulin level were measured.Insulin resistance index,body mass index,waist/hip ratio,percentage of body fat and fibrosis progression rate were calculated.Applied dose of interferon and ribavirin,platelet and neutrophil count and hemoglobin level were measured.RESULTS:A sustained virological response(SVR) was significantly associated with IL28B polymorphism(CC vs TT allele:odds ratio(OR),25;CC vs CT allele:OR,5.4),inflammation activity(G < 1 vs G > 1:OR,3.9),fibrosis(F < 1 vs F > 1:OR,5.9),platelet count(> 200 × 10 9 /L vs < 200 × 10 9 /L:OR,4.7;OR in patients with genotype CT:12.8),fatty liver(absence vs presence of steatosis:OR,4.8),insulin resistance index(< 2.5 vs > 2.5:OR,3.9),and baseline HCV viral load(< 10 6 IU/mL vs > 10 6 IU/mL:OR,3.0).There was no association with age,sex,aminotransferases activity,body mass index,waist/hip ratio,or percentage body fat.There was borderline significance(P = 0.064) of increased fibrosis in patients with the TT allele,and no differences in the insulin resistance index between groups of patients with CC,CT and TT alleles(P = 0.12).Spearman's rank correlation coefficient between insulin resistance and stage of fibrosis and body mass index was r = 0.618 and r = 0.605,respectively(P < 0.001).Significant differences were found in the insulin resistance index(P = 0.01) between patients with and without steatosis.Patients with the CT allele and absence of a SVR had a higher incidence of requiring threshold dose reduction of interferon(P = 0.07).CONCLUSION:IL28B variation is the strongest host factor not related to insulin resistance that determines outcome of antiviral therapy.Baseline platelet count predicts the outcome of antiviral therapy in CT allele patients. | Andrzej Ciela Monika Bociaga-Jasik Iwona Sobczyk-Krupiarz Mikolaj K Glowacki Danuta Owczarek Dorota Cibor Marek Sanak Tomasz Mach | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 4 | Hemangiomas and vascular malformations in infants and children:a classification based on endothelial characteristics显示文摘 | Mulliken JB Glowacki J | 1982 | Plast Reconstr Surg1982，69，： | 2 |
| 5 | Hemangiomas and Vascular Malformations in Infants and Children: A Classification Based on Endothelial Characteristics显示文摘 | John B. Mulliken Julie Glowacki | 1982 | Plastic and Reconstructive Surgery1982，，3： | 2 |
| 6 | Hemangiomas and vascular malformations in infants and children:a classification based on endnthelial characteristics 显示文摘 | Mulliken JB Glowacki J | 1982 | Plast Reconstr Surg1982，69，3： | 1 |
| 7 | Niobium based intermetallics as a source of high-current/high magnetic field superconductors显示文摘 | Glowacki B A Yah X Y Fray D | 2002 | Physics C: Superconductivity and its Applications2002，，3： | 1 |
| 8 | Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics显示文摘 | Mulliken JB Glowacki J | 1982 | Plast Reconstr Surg1982，69，3： | 1 |
| 9 | Hernangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics 显示文摘 | Mulliken JB Glowacki J | 1982 | Plast Reconstr Surg1982，69，： | 1 |
| 10 | Increased circulating miR- 21 levels are associated with kidney fibrosis显示文摘 | Glowacki F Savary G Gnemmi V | 2013 | PLoS One2013，8，58： | 1 |
| 11 | Hemangiomas and vascular malformations in infants and children:a classification based on endothelial characteristics显示文摘 | Mulliken JB Glowacki J | 1982 | Plast Reconstr Surg1982，69，3： | 1 |
| 12 | Hemangiomas and vascular malformations in infants and children:a classification based on endothelial characteristics显示文摘 | MulIiken JB Glowacki J | 1982 | Plast Reconstr Surg1982，69，3： | 1 |
| 13 | Hemangiomas and malformationsin infants and childien:a classification based on endothelial characteristics显示文摘 | Mulliken JB Glowacki J | 1982 | Plas Reconstr Surg1982，63，： | 1 |
| 14 | Hemangiomas and vascular malformations in in- fants and children :A classification based on endothelial characteristics显示文摘 | Mulliken JB Glowacki J | 1982 | Plast Reconstr Surg1982，69，3： | 1 |
| 15 | The roles of revascularization and resorption on endurance of craniofacial onlay bone grafts in the rabbit显示文摘 | Chen NT Glowacki J Bucky LP | 1994 | Plast Reconstr Surg1994，93，4： | 1 |
| 16 | Effects of resistance, endurance, and concurrent exercise on training outcomes in men 显示文摘 | GLOWACKI S P MARTIN S E MAURER A | 2004 | Med Sci Sports Exe2004，36，12： | 1 |
| 17 | Col agens Scaffolds for tissue engineering显示文摘 | Glowacki J Mizuno S | | 0，，： | 1 |
| 18 | Hemangiomas and vascular maoforma- tions in infants and children: a classification based on endothe- lial characteristics显示文摘 | Mulliken JB Glowacki J | 1982 | Plast Reeonstr Surg1982，69，3： | 1 |
| 19 | Perfusion enchances functions of bone marrow stromal cells in three-dimensional culture显示文摘 | Glowacki J Mizuno S Greengerger JS | 1998 | Cell Transplant1998，7，3： | 1 |
| 20 | Niobium based intermetallics as a source of high-current/high magnetic field superconductors 显示文摘 | GLOWACKI B A YAN X Y FRAY D | 2002 | Physica C2002，372，： | 1 |
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