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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Interactions between intraluminal bile acids and digestive products on pancreatic and gallbladder function显示文摘 | Malagelada J R Go V L DiMagno E P | 1973 | J Clin Invest1973，52，9： | 1 |
| 3 | Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans显示文摘 | Eap CB Lessard E Baumann P Brawand-Amey M Yessine MA Hara GO | 2003 | Pharmacogenetics2003，13，： | 1 |
| 4 | A mass spectrometry plate reader: Monitoring enzyme activity and inhibition with a desorption/ioni- zation on silicon (DIOS) platform显示文摘 | Shen Z Go E P Gamez A | 2004 | Chem Bio Chem2004，5，7： | 1 |
| 5 | Third-generation nephrectomy by natural orifice transluminal endoscopic surgery显示文摘 | Lima E Rolanda C Pêgo JM | 2007 | J Urol2007，178，6： | 1 |
| 6 | Clinical transplantation of a tissue-engineered airway显示文摘 | Paolo Macchiarini Philipp Jungebluth Tetsuhiko Go M Adelaide Asnaghi Louisa E Rees Tristan A Cogan Amanda Dodson Jaume Martorell Silvia Bellini Pier Paolo Parnigotto Sally C Dickinson Anthony P Hollander Sara Mantero Maria Teresa Conconi Martin A Birchall | 2008 | The Lancet2008，，9655： | 1 |
| 7 | Third-generation cholecystectomy by natural orifices:transgastric and transvesical combined approach (with video)显示文摘 | Rolanda C Lima E Pêgo J M | 2007 | Gastrointest Endosc2007，65，1： | 1 |
| 8 | GlycoPep DB:A tool for glycopeptide analysis using a 'Smart Search'显示文摘 | GO E P REBECCHI K R DALPATHADO D S | 2007 | Anal Chem2007，79，4： | 1 |
| 9 | Environmental photochenmistry on semiconductorsurface :photosensitized degradation of atextile ayo dye,acid orarge 7on TiO2 particlesusingvisible light显示文摘 | VINOD GO PSL K DSRREL E WYNKOO P | 1996 | Environ Sci Technol1996，30，： | 1 |
| 10 | Database resources in metabolomics:an overview显示文摘 | GO E P | 2010 | J Neuroimmune Pharmacol2010，5，1： | 1 |
| 11 | Transvesical endoscopic peritoneoscopy:a novel 5 mm port for intra-abdominal scarless surgery显示文摘 | Lima E Rolanda C Pêgo JM | 2006 | J Urol2006，176，2： | 1 |
| 12 | Elastofibroma dorsi= a soft tissue masquerade显示文摘 | Go P H Meadows M C Deleon E M | 2010 | Int J Shoulder Surg2010，4，4： | 1 |
| 13 | Osteogenic differentiation of mesenchymal stem cells using PAMAM dendrimers as gene delivery vectors显示文摘 | Santos J L Oramas E Pêgo A P | 2009 | J Control Release2009，1，134： | 1 |
| 14 | Functional ability in patients with critical limb ischaemia is unaffected by successful revascularisa-tion 显示文摘 | Cieri E Lenti M De Ran go P | 2011 | Eur J Vase Endovaac Surg2011，41，2： | 1 |
| 15 | Evaluation of the gingivalinflammation in pregnancy and postpartum via 25-hydroxy-vitaminD3, prostaglandin E2 and TNF-alpha levels in saliva 显示文摘 | GO mu § P Oztii rk V0 Bozkurt E | 2016 | Arch OralBiol2016，63，3： | 1 |
| 16 | Is partial root-zone drying an effective irrigation technique to improve water use efficiency and fruit quality in field-grown wine grapes un- der semiarid conditions 显示文摘 | M L De La Hera P Romero E Go'mez-Plaza | 2007 | Agricultural water management2007，87，： | 1 |
| 17 | Mortality and morbidity in very low birth weight infants in theBasque Country and Navarra(2001-2006):population-basedstudy显示文摘 | Santesteban Otazu E Rodríguez Serna A Goi Orayen C PérezLegorburu A Echeverría Lecuona MJ Martínez Ayucar MM etal | 2012 | An Pediatr(Barc)2012，77，5： | 1 |
| 18 | Glycosylation sitespecific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes accessibility显示文摘 | Go E P Irungu J Zhang Y | 2008 | J Proteome Res2008，7，4： | 1 |
| 19 | Are there specific meta-cognitions as- sociated with vulnerability to symptoms of worry and obsessional thoughts? 显示文摘 | Bruin GO Muris P Rassin E | 2007 | Pers Individ Differ2007，42，4： | 1 |
| 20 | Environmental monitoring near industrial sites : acrylonitrile 显示文摘 | Going J E Kuykendaho P Long S | 1978 | US Environmental Protection Agency1978，，6： | 1 |
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