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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | Sacroiliac joint stability: Finite element analysis of implant number, orientation, and superior implant length显示文摘AIM To analyze how various implants placement variables affect sacroiliac(SI) joint range of motion. METHODS An experimentally validated finite element model of the lumbar spine and pelvis was used to simulate a fusion of the SI joint using various placement configurations of triangular implants(iF use Implant System~?). Placement configurations were varied by changing implant orientation, superior implant length, and number of implants. The range of motion of the SI joint was calculated using a constant moment of 10 N-m with a follower load of 400 N. The changes in motion were compared between the treatment groups to assess how the different variables affected the overall motion of the SI joint. RESULTS Transarticular placement of 3 implants with superior implants that end in the middle of the sacrum resulted in the greatest reduction in range of motion(flexion/extension = 73%, lateral bending = 42%, axial rotation = 72%). The range of motions of the SI joints were reduced with use of transarticular orientation(9%-18%) when compared with an inline orientation. The use of a superior implant that ended mid-sacrum resulted in median reductions of(8%-14%) when compared with a superior implant that ended in the middle of the ala. Reducing the number of implants, resulted in increased SI joint range of motions for the 1 and 2 implant models of 29%-133% and 2%-39%, respectively,when compared with the 3 implant model.CONCLUSION Using a validated finite element model we demonstrated that placement of 3 implants across the SI joint using a transarticular orientation with superior implant reaching the sacral midline resulted in the most stable construct. Additional clinical studies may be required to confirm these results. | Derek P Lindsey Ali Kiapour Scott A Yerby Vijay K Goel | 2018 | World Journal of Orthopedics2018，9，3： | 3 |
| 3 | In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus显示文摘Objective: To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis. Methods: The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis ( M. philippinensis ) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus ( E. granulosus ), under in-vitro conditions with reference to the known standard drug Praziquantel . Results: At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation. Conclusions: As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects. | Mayank Gangwar Vijay C Verma Tryambak D Singh Sushil K Singh RK Goel Gopal Nath | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，8： | 3 |
| 4 | Management of polytrauma patients in emergency department:An experience of a tertiary care health institution of northern India显示文摘BACKGROUND:In a tertiary care institute of northern India,the emergency department receives an average of 6-7 patients with poly trauma every day.Of these patients,some come directly and many are referred from other hospitals from the region.Various problems are faced in the management of patients with poly trauma.This study aimed to elicit various complaints,suggestions and possible solutions in the management of patients with poly trauma.METHODS:A retrospective cross sectional study was done on 210 patients in the emergency OPD for a period of 2 months.All the records of the patients with poly trauma were studied and the problems during their management were measured against 6 predetermined steps(step Ⅰ to step Ⅵ).RESULTS:In the younger generation,males were predominantly the primary victims of poly trauma injury,and road traffic accident was the major etiological factor.Injuries involving more than2 specialties induced many problems during the management of patients with poly trauma.Of 210 patients we studied,32 patients had problems at various steps and maximum problems in step Ⅲ,i.e.co-ordination between various specialties in the management of patients with poly trauma.CONCLUSION:A proper poly trauma management team and a well defined standard operative procedure are the keys to effective management of patients with poly trauma by minimizing the problems encountered. | Puri Payal Goel Sonu Gupta Anil K Verma Prachi | 2013 | World Journal of Emergency Medicine2013，4，1： | 2 |
| 5 | Generation of microcellular polymeric foams using supercritical carbon dioxide- Ⅰ: Effect of pressure and temperature on nucleation显示文摘 | Goel S K | 1994 | Polymer Engineering and Science1994，34，14： | 1 |
| 6 | A modal pushover analysis procedure for estimating seismic demands for buildings显示文摘 | Chopra A K Goel R K | 2002 | Earthquake Engineering and Structural Dynamics2002，31，： | 1 |
| 7 | Interlaminar shear stresses and laminae separation in a disc 显示文摘 | Goel V K Monroe B T Gilbertson L G | 1995 | Spine1995，20，6： | 1 |
| 8 | A modal pushover analysis procedure for estimating seismic demands for buildings 显示文摘 | Chopra A K Goel R K | 2002 | Earthquake Engineering and Structural Dynamics2002，31，2： | 1 |
| 9 | Surgery for syringomyelia: an analysis based on 163 surgical cases 显示文摘 | Goel A Desai K | 2000 | Acat Neurochir (Wien)2000，142，3： | 1 |
| 10 | Kinematic of the cervieal spine followingdisceteomy and stabilization显示文摘 | Schulte K Clark CR Goel VE | 1989 | Spne1989，14，10： | 1 |
| 11 | A model pushover procedure to estimate seismic demands for buildings 显示文摘 | ANIL K CHOPRA RAKESH K GOEL | 2002 | Earthquake Engineering and Structural Dynamics2002，31，： | 1 |
| 12 | 显示文摘 | Goel M Roy S K Sengupta S | 1994 | Heat Mass Transfer1994，37，4： | 1 |
| 13 | Retailer's optimal replenishment decisions with credit-linked demand under permissible delay in payments显示文摘 | Jaggi C K Goyal S K Goel S K | 2008 | European Journal of Operational Research2008，，190： | 1 |
| 14 | Generation of microcelular polymeric foams using supercritical carbon dioxide : Cell growth and skin formation显示文摘 | Goel S K | 1994 | Polymer Engineering and Science1994，34，14： | 1 |
| 15 | Effect of disc degeneration at one level on the adjacent level in axial mode 显示文摘 | Kim Y E Goel V K Weinstein J N | 1991 | Spine1991，16，3： | 1 |
| 16 | Effect of MoO3 addition on the grain growth kinetics of a manganese zinc ferrite 显示文摘 | Gain G C Das B K Goel N C | 1979 | J Amer Ceram Soc1979，62，12： | 1 |
| 17 | Surgery for syringomyelia:an analysis based on 163 surgical cases显示文摘 | Goel A Desai K | 2000 | Acta Neurochir(Wien)2000，142，3： | 1 |
| 18 | Support Pressure Assessment in Arched Underground Openings Through Poor Rock Masses显示文摘 | Singh B Goel R K Jethwa J L etc | 1997 | Engineering Geology1997，，48： | 1 |
| 19 | Bolt length requirement in underground openings 显示文摘 | Goel R K Anil Swarup Sheorey P R | 2007 | International Journal of Rock Mechanics and Mining Sciences2007，44，5： | 1 |
| 20 | High performance Ni-substituted Mn-Zn ferrites processed by soft chemical technique显示文摘 | SINGH A K SINGH A K GOEL T C MENDIRATTA R G | 2004 | Journal of Magnetism and Magnetic Materials2004，28，23： | 1 |
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