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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration显示文摘 | Arora S Ranade AR Tran NL Nasser S Sridhar S Korn RL Ross JT Dhruv H Foss KM Sibenaller Z Ryken T Gotway MB Kim S Weiss GJ | 2011 | 中国神经肿瘤杂志2011，9，1： | 30 |
| 3 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 4 | Circular noncoding RNAs as potential therapies and circulating biomarkers for cardiovascular diseases显示文摘在染色体宽的分析和定序 RNA 技术的最近的前进导致了小 noncoding RNA 的发现,例如 microRNAs (米尔) ,以及两线性长 noncoding RNA (lncRNAs ) 和圆形的长 noncoding RNA (circRNAs ) 。在心血管的疾病(CVD ) 的治疗,预后和诊断的米尔和 lncRNAs 的重要性广泛地被报导了。我们以前也为 CVD 在治疗并且作为 biomarkers 考察了他们的含意。更最近, circRNAs 也在 CVD 作为重要管理者出现了。CircRNAs 是被背送信人前 RNA (pre-mRNAs ) 的特定的区域拼接产生的圆形的染色体产品。对 circRNAs 的成长兴趣导致了他们的 pathophysiological 功能的一个宽数组的发现。CircRNAs 被显示了是象心肌的梗塞,动脉粥样硬化,心肌症和心脏的纤维变性那样的 CVD 的关键管理者。因此, circRNAs 最近为 CVD 作为潜在的治疗学的目标和 biomarkers 被建议了。在这评论,我们在 circRNAs 上总结文学的当前的状态,以他们的生物的续生说和行动的全球机制开始。我们然后在各种各样的 CVD 提供他们的参与的一个提要。最后,我们为 CVD 的早察觉作为 biomarkers 强调 circRNAs 的大潜力,并且讨论作为有希望的 biomarkers 加亮 circRNAs 的利用的几项专利和最近的报纸。 | Ahmed S BAYOUMI Tatsuya AONUMA Jian-peng TEOH Yao-liang TANG II-man KIM | 2018 | Acta Pharmacologica Sinica2018，39，7： | 16 |
| 5 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 6 | 普瑞巴林治疗中枢卒中后疼痛的安全性和疗效显示文摘全文刊登在:Kim,J S,et al.Pain 2011:1-6.研究背景·研究证实普瑞巴林可有效应用于几种类型的神经病理性疼痛。 | Kim J S | 2011 | 中国新药杂志2011，20，8： | 13 |
| 7 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 8 | 用RFLP方法研究陕西省主要小麦品种遗传多样性及其演变显示文摘研究用RFLP方法,对我国主要小麦产区,陕西省40年代以来广为种植的小麦品种的遗传多样性进行了研究,结果表明,占总带数26.2%的HINDII酶的RFLP带具有遗传多态性。24个小麦品种平均遗传相似系数为0.948。53.8%的探针显示了多态性。平均多态性信息含量指数为0.252。陕西省小麦品种遗传多样性以70年代为最高,之后开始降低。 | 朱列层 唐国顺 HAZEN S P KIM H S WARD R W | 1999 | 西北植物学报1999，19，2： | 11 |
| 9 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 10 | 罹患高血压的非洲裔美国人和美国白人的肠道微生物群及血清代谢物差异显示文摘非洲裔美国人高血压患病率、严重程度和高血压治疗抵抗均高于美国白人。肠道微生物菌群及其代谢产物的不同可能是造成这种现象的原因。为此,Walejko等收集研究人群的粪便和血液样本分别用于肠道微生物群的全基因组测序(whole genome sequencing,WGS)和血清整体非靶向代谢组学研究,对上述假设进行了验证。 | Walejko JM Kim S Goel R Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 7 |
| 11 | 全光纤调Q掺铒光纤激光器的脉冲研究显示文摘报道一种全光纤调Q掺铒光纤激光器 ,在其结构中采用带有光纤光栅的光纤环形镜作为调Q装置 此调Q方案同时具有对腔内损耗进行调制和对激光输出波长选择的功能 理论上分析了不同臂长差时的脉冲出现情况 ,与实验基本相符 | 夏江珍 蔡海文 任虹 瞿荣辉 陈高庭 方祖捷 KIM Insoo S | 2002 | 光子学报2002，31，8： | 6 |
| 12 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 13 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 14 | 流过多孔介质的流体研究(英文)显示文摘研究流过密集的具二次变化渗透性的重叠理想聚合体的流体.流体流由达西定律的布林克曼扩展及连续方程来刻画,通过引入流函数,求出上述方程在适当边界条件下的解析解,并将结果与一些已知的结果进行了比较. | 元荣 Albert S Kim | 2011 | 应用泛函分析学报2011，13，4： | 5 |
| 15 | Similarity measure application to fault detection of flight system显示文摘差错察觉技术与类似措施被介绍。常规类似措施的特征基于模糊数字被讨论。在距离措施的帮助下,类似措施明确地被构造。设计基于距离的类似措施对包括非凸的模糊会员功能的一般模糊会员功能适用,而模糊基于数字的类似措施有限制计算一般模糊会员功能的类似。到一般模糊会员结构的建议类似措施的适用性被识别定义证明。为了决定,指责飞行系统的察觉,试验性的数据(投球的时刻系数和电梯系数) 被转变成模糊会员函数。基于距离的类似措施被用于获得的模糊会员功能,和类似计算,分析与差错和正常操作系数被获得。 | KIM J H LEE S H 王洪梅 | 2009 | Journal of Central South University2009，16，5： | 5 |
| 16 | G652光纤中背向自发拉曼散射的增益特性显示文摘讨论了背向自发Raman散射脉冲在自生分布式G652光纤Raman放大器中传输的增益特性。实验发现,反Stokes Raman(ASR)和Stokes Raman(SR)自生分布式脉冲光纤Raman放大器的阈值抽运峰值功率是25.4 W和18.0 W。在入射功率为52 W时,ASR和SR的增益分别为5.0 dB和8.6 dB。放大的反Stokes和Stokes背向自发Raman散射光时域反射(OTDR)曲线上放大的阈值时间位置随激发功率的增高前移并具有规律性。放大的ASR背向自发散射强度受光纤温度调制,具有温度效应,已应用于远程分布光纤Raman温度传感器系统。 | 王剑锋 张在宣 徐海峰 余向东 Insoo S KIM | 2006 | 光电子.激光2006，17，7： | 5 |
| 17 | Diffusion-weighted single-shot echoplanar MR imaging for liver disease显示文摘 | Kim T Murakami T Takahashi S | 1999 | AJR1999，173，2： | 4 |
| 18 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 19 | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection显示文摘Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. | Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim Yijuan Sun Kavitha Ganta Antonios H Tzamaloukas | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 20 | 在脑病理状态下星形胶质细胞介导的突触重塑显示文摘星形胶质细胞是胶质细胞的主要类型,对神经元突触间的信号传递和联系起到反馈作用,构成'三重突触结构'。在大脑发育的过程中,星形胶质细胞的代谢型谷氨酸受体介导钙离子波并释放胶质递质或突触发生分子,介导神经元.胶质细胞间的联系,但在成年大脑中,尚不清楚是否存在此信号通路。但越来越多的证据显示,当成年大脑处于病理状态下,成熟的星形胶质细胞也重新表现出非成熟星形胶质细胞的表型。星形胶质细胞表型的这种非成熟转变可以导致神经环路和突触的重塑。在本综述中,笔者总结了大脑发育过程中星形胶质细胞介导的突触重塑,讨论了成年脑病理过程中非成熟星形胶质细胞信号通路的重现,并重点讨论这些信号通路对病理过程中与脑功能改变有关的突触连接重塑的意义。 | Kim SK Nabekura J Koizumi S 唐颖馨(编译) | 2017 | 神经损伤与功能重建2017，12，4： | 4 |
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