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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Growth of rainbow trout fed a diet supplemented with earthworms, after chemical treatment显示文摘 | Pereira J O Gomes E F | 1995 | Aquaculture International1995，3，： | 1 |
| 3 | Numerical modeling of an industrial aluminum melting furnace显示文摘 | Nieckele A O Naccache M F Gomes M S P | 2004 | Journal of Energy Resources Technology2004，126，1： | 1 |
| 4 | Pre- referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial 显示文摘 | GOMES M F FAIZ M A GYAPONG J O | 2009 | Lancet2009，373，9663： | 1 |
| 5 | Use of sugarcane bagacse and grass hydrolysates as carbon sources for xylanase production by Bacillus cira()in submerged fermentation显示文摘 | Bocchini D A Oliveira O M M F Gomes E | 2005 | Process Biochemistry2005，40，： | 1 |
| 6 | Automotive catalyst deactivation: Case studies 显示文摘 | Zotin F M Z Gomes O F M Oliveira C H | 2005 | Catalysis Today2005，107，108： | 1 |
| 7 | Capsule expression by bovine isolates of Staphylococcus aureus from Argentina:genetic and epidemiologic analyses显示文摘 | Sordelli D O F R Buzzola M I Gomes | 2000 | Clin Microbiol2000，38，： | 1 |
| 8 | Selective oxidation of limonene and β-pinene catalyzed by Co(OAc)2显示文摘 | GOMES M F T ANTUNES O A C | 1997 | J Mol Catal A1997，121，： | 1 |
| 9 | Fused deposition modeling with polypropylene 显示文摘 | CARNEIRO O S SILVA A F GOMES R | 2015 | Mater Des2015，83，： | 1 |
| 10 | Evaluation of the efficacy of triple therapy regimen for Helicobacter pylori eradication in gastrectomized patients with gastric adenocarcinoma显示文摘 | Jose Luiz Bertoli Neto Laercio Gomes Louren?o Cícero Fernando Bertoli Fábio Samsonowski Ulbrich Antoninho Ricardo Sabbi Alexandre Galv?o Bueno | 2006 | Gastric Cancer2006，，4： | 1 |
| 11 | Influence of the addition of rare-earth elements on the sintering of cemented carbide 显示文摘 | Gomes C M F Santos L C O Silva A G P | 2006 | Materials Science Forum2006，，530531： | 1 |
| 12 | Automotive catalyst deactivation:Case studies显示文摘 | Zotin F M Z Gomes O F M Oliveira C H | 2005 | Catalysis Today2005，，： | 1 |
| 13 | Neonatal minimally invasive surgery for congenital diaphragmatic hernias: a multicenter study usingthoracoscopy or laparoscopy 显示文摘 | Gomes Ferreira C Reinberg O Becmeur F | 2009 | Surg Endosc2009，23，7： | 1 |
| 14 | The distri- bution of genetic variability in Baccharis concinna (Aster- aceae), an endemic, dioecious and threatened shrub of rupestrian fields of Brazil显示文摘 | Gomes V Collevatti R G Silveira F A O | 2004 | Conservtion Genetics2004，5，2： | 1 |
| 15 | The effect of fiber morphology on the tensile strength of natural fibers显示文摘 | Alves Fidelis M E Pereira T V C Gomes O D F M | 2013 | Journal of Materials Research and Technology2013，2，2： | 1 |
| 16 | Multi-criteria design optimization study of solvent extraction in mixer- settler units 显示文摘 | Pinto G A Gomes E F Duro F O | 2009 | Hydrometallurgy2009，98，3： | 1 |
| 17 | Analysis and functional annotation of an expressed sequence tag collection for tropical crop sugarcane显示文摘 | Vettore A L Silva F R Kemper E L Souza G M Silva A M Ferro M I T Silva F H Giglioti E A Lemos M V F Coutinho L L Nobrega M P Carrer H Franca S C Bacci Junior M Goldman M H S Gomes S L Nunes L R Camargo L E A Siqueira W J Sluys M V Thiemann O H Kuramae E E | | 0，，： | 1 |
| 18 | The gastric ulcerprotective and healing role of cysteine proteinases from Carica candamarcensis显示文摘 | Mello V J Gomes M T R Lemos F O | 2008 | Phytomedicine2008，15，4： | 1 |
| 19 | Determination of glyphosate in water samples by IC 显示文摘 | Marques M N Passos E A da Silva M T Correia F O Santos A M Gomes S S Alves J P | 2009 | Journal of Chromatographic Science2009，47，9： | 1 |
| 20 | Neonatal minimally invasive surgery for congenital diaphragmatic hernias: a multicenter study using thoracoscopy or la- paroscopy 显示文摘 | Gomes Ferreira C Reinberg O Becmeur F | 2009 | Surg Endosc2009，23，7： | 1 |
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