|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 东天山觉罗塔格红云滩花岗岩年代学、地球化学及其构造意义显示文摘东天山觉罗塔格地区广泛发育的晚古生代岩浆岩及相关的矿产一直是东天山大地构造研究的焦点。觉罗塔格南缘红云滩花岗质岩体的岩石、矿物组合显示典型的钙碱性火山弧花岗岩特征。岩石地球化学研究表明,该花岗质岩石富集大离子亲石元素而亏损高场强元素,是洋壳俯冲所导致的下地壳物质部分熔融、岩浆分离结晶和上地壳同化混染作用的产物。LAM-ICP/MS锆石定年结果表明,红云滩花岗岩侵位于早-中石炭世(328.5±9.3Ma)。结合觉罗塔格地区由南至北,晚古生代矿产分布由火山沉积-热液改造型铁矿向斑岩型铜钼矿过渡的特征、火山-沉积岩分布和该区晚古生代的大地构造演化历史,作者推测:早古生代觉罗塔格洋向塔里木板块俯冲并形成中天山岛弧之后,该洋盆并未完全消亡,并于晚古生代时极性反转,向北俯冲于准-吐-哈地块之下。红云滩花岗岩正是形成于晚古生代觉罗塔格俯冲洋壳之上的火山弧环境。觉罗塔格地区晚古生代的岩浆岩,火山-沉积岩和矿产分布均不同程度受控于这一大地构造背景。 | 吴昌志 张遵忠 Khin Zaw Fernando Della-Pasque 唐俊华 郑远川 汪传胜 三金柱 | 2006 | 岩石学报2006，22，5： | 93 |
| 2 | Pathophysiological 角色和在糖尿病的 nephropathy 的发炎的治疗学的含意显示文摘 Diabetes mellitus and its complications are becoming one of the most important health problems in the world. Diabetic nephropathy is now the main cause of end-stage renal disease. The mechanisms leading tothe development and progression of renal injury are not well known. Therefore, it is very important to f ind new pathogenic pathways to provide opportunities for early diagnosis and targets for novel treatments. At the present time, we know that activation of innate immunity with development of a chronic low grade inflammatory response is a recognized factor in the pathogenesis of diabetic nephropathy. Numerous experimental and clinical studies have shown the participation of different inflammatory molecules and pathways in the pathophysiology of this complication. | Desirée Luis-Rodríguez Alberto Martínez-Castelao José Luis Górriz Fernando de lvaro Juan F Navarro-González | 2012 | World Journal of Diabetes2012，3，1： | 55 |
| 3 | Current knowledge on esophageal atresia显示文摘Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is the most common congenital anomaly of the esophagus. The improvement of survival observed over the previous two decades is multifactorial and largely attributable to advances in neonatal intensive care, neonatal anesthesia, ventilatory and nutritional support, antibiotics, early surgical intervention, surgical materials and techniques. Indeed, mortality is currently limited to those cases with coexisting severe life-threatening anomalies. The diagnosis of EA is most commonly made during the first 24 h of life but may occur either antenatally or may be delayed. The primary surgical correction for EA and TEF is the best option in the absence of severe malformations. There is no ideal replacement for the esophagus and the optimal surgical treatment for patients with long-gap EA is still contro-versial. The primary complications during the postoperative period are leak and stenosis of the anastomosis, gastro-esophageal reflux, esophageal dysmotility, fistula recurrence, respiratory disorders and deformities of the thoracic wall. Data regarding long-term outcomes and follow-ups are limited for patients following EA/TEF repair. The determination of the risk factors for the complicated evolution following EA/TEF repair may positively impact long-term prognoses. Much remains to be studied regarding this condition. This manuscript provides a literature review of the current knowledge regarding EA. | Paulo Fernando Martins Pinheiro Ana Cristina Simoes e Silva Regina Maria Pereira | 2012 | World Journal of Gastroenterology2012，18，28： | 35 |
| 4 | Revisions to the Tumor,Node,Metastasis staging of lung cancer(8th edition):Rationale,radiologic findings and clinical implications显示文摘The Tumor, Node, Metastasis(TNM) staging system,adopted by the Union for International Cancer Control(UICC) and the American Joint Committee on Cancer(AJCC), has been recently revised, with the new 8^(th) edition of the staging manual being published in January 2017. This edition has few but important evidencebased changes to the TNM staging system used for lung cancer. Radiologists should be aware of the updated classification system to accurately provide staging information to oncologists and oncosurgeons. In this article, we discuss the rationale, illustrate the changes with relevance to Radiology, and review the clinical implications of the 8^(th) edition of the UICC/AJCC TNM staging system with regards to lung cancer. | Fernando U Kay Asha Kandathil Kiran Batra Sachin S Saboo Suhny Abbara Prabhakar Rajiah | 2017 | World Journal of Radiology2017，9，6： | 39 |
| 5 | Physical exercise in the prevention and treatment of Alzheimer’s disease显示文摘Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations. | Adrian De la Rosa Gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-Pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther Garcia-Dominguez Aitor Carretero Angela G.Correas Jose Vina Mari Carmen Gomez-Cabrera | 2020 | Journal of Sport and Health Science2020，9，5： | 32 |
| 6 | Modeling sustainability:population,inequality,consumption,and bidirectional coupling of the Earth and Human Systems显示文摘Over the last two centuries,the impact of the Human System has grown dramatically,becoming strongly dominant within the Earth System in many diferent ways.Consumption,inequality,and population have increased extremely fast,especially since about 1950,threatening to overwhelm the many critical functions and ecosystems of the Earth System.Changes in the Earth System,in turn,have important feedback efects on the Human System,with costly and potentially serious consequences.However,current models do not incorporate these critical feedbacks.We argue that in order to understand the dynamics of either system,Earth System Models must be coupled with Human System Models through bidirectional couplings representing the positive,negative,and delayed feedbacks that exist in the real systems.In particular,key Human System variables,such as demographics,inequality,economic growth,and migration,are not coupled with the Earth System but are instead driven by exogenous estimates,such as United Nations population projections.his makes current models likely to miss important feedbacks in the real Earth–Human system,especially those that may result in unexpected or counterintuitive outcomes,and thus requiring diferent policy interventions from current models.he importance and imminence of sustainability challenges,the dominant role of the Human System in the Earth System,and the essential roles the Earth System plays for the Human System,all call for collaboration of natural scientists,social scientists,and engineers in multidisciplinary research and modeling to develop coupled Earth–Human system models for devising efective science-based policies and measures to beneit current and future generations. | Safa Motesharrei Jorge Rivas Eugenia Kalnay Ghassem R.Asrar Antonio J.Busalacchi Robert F.Cahalan Mark A.Cane Rita R.Colwell Kuishuang Feng Rachel S.Franklin Klaus Hubacek Fernando Miralles-Wilhelm Takemasa Miyoshi Matthias Ruth Roald Sagdeev Adel Shirmohammadi Jagadish Shukla Jelena Srebric Victor M.Yakovenko Ning Zeng | 2016 | National Science Review2016，3，4： | 34 |
| 7 | Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori显示文摘AIM: To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H pylori).METHODS: Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled H pylori to stomach sections. RESULTS: Of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against H pylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric; borage and parsley were able to inhibit the adhesion of H pylori strains to the stomach sections.CONCLUSION: Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on H pylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment. | Rachel O'Mahony Huda Al-Khtheeri Deepaka Weerasekera Neluka Fernando Dino Vaira John Holton Christelle Basset | 2005 | World Journal of Gastroenterology2005，11，47： | 29 |
| 8 | Venous thrombosis and prothrombotic factors in inflammatory bowel disease显示文摘Patients with inflammatory bowel disease(IBD)may have an increased risk of venous thrombosis(VTE).PubMed,ISI Web of Knowledge and Scopus were searched to identify studies investigating the risk of VTE and the prevalence of acquired and genetic VTE risk factors and prothrombotic abnormalities in IBD.Overall,IBD patients have a two-to fourfold increased risk of VTE compared with healthy controls,with an overall incidence rate of 1%-8%.The majority of studies did not show significant differences in the risk of VTE between Crohn’s disease and ulcerative colitis.Several acquired factors are responsible for the increased risk of VTEin IBD:inflammatory activity,hospitalisation,surgery,pregnancy,disease phenotype(e.g.,fistulising disease,colonic involvement and extensive involvement)and drug therapy(mainly steroids).There is also convincing evidence from basic science and from clinical and epidemiological studies that IBD is associated with several prothrombotic abnormalities,including initiation of the coagulation system,downregulation of natural anticoagulant mechanisms,impairment of fibrinolysis,increased platelet count and reactivity and dysfunction of the endothelium.Classical genetic alterations are not generally found more often in IBD patients than in nonIBD patients,suggesting that genetics does not explain the greater risk of VTE in these patients.IBD VTE may have clinical specificities,namely an earlier first episode of VTE in life,high recurrence rate,decreased efficacy of some drugs in preventing further episodes and poor prognosis.Clinicians should be aware of these risks,and adequate prophylactic actions should be taken in patients who have disease activity,are hospitalised,are submitted to surgery or are undergoing treatment. | Fernando Magro Jo?o-Bruno Soares Dália Fernandes | 2014 | World Journal of Gastroenterology2014，20，17： | 27 |
| 9 | 渤海海水淡化反渗透法的预处理工艺显示文摘采用'消毒—混凝—澄清—砂滤'、'消毒—混凝—澄清—砂滤—超滤'以及'消毒—砂滤—超滤'三套海水淡化预处理工艺进行了试验对比。试验的目的在于获取可行的反渗透预处理工艺。表明,采用'消毒—混凝—澄清—砂滤—超滤'工艺或'消毒—砂滤—超滤'工艺是技术可行的反渗透预处理工艺,其中次氯酸钠为可选消毒剂,三氯化铁为较好的混凝剂,而超滤是不可或缺的单元处理工艺。 | 龙泽波 张大群 张万钦 张寿生 赵文喜 Fernando Javier 赵斌 张英峰 | 2003 | 城市环境与城市生态2003，16，6： | 22 |
| 10 | Bevacizumab for the management of diabetic macular edema显示文摘Diabetic retinopathy (DR) is a leading cause of vision loss in the working-age population and is relatedto 1%-5% of cases of blindness worldwide. Diabetic macular edema (DME) is the most frequent cause of DR vision loss and is an important public health problem. Recent studies have implicated vascular endothelial growth factor (VEGF) in DR and DME pathogenesis, as well as provided evidence of the benefits of anti-VEGF agents for the management of such conditions. Despite the benefits of intravitreal ranibizumab injection for the management of DME, the cost-effectiveness of intravitreal bevacizumab therapy has gained increasing interest in the scientific community. This review summarizes the studies examining bevacizumab for the management of DME, focusing on the efficacy and duration of the clinical benefits of decreasing DME and the improvement of best-corrected visual acuity (BCVA). There is strong evidence that intravitreal bevacizumab injection therapy has a good cost-effective profile in the management of DME and may be associated with laser photocoagulation; however, its clinical superiority in terms of the duration of DME regression and the improvement of BCVA compared with intravitreal ranibizumab and other intravitreal anti-VEGF therapies remains unclear and deserves further investigation. | Francisco Rosa Stefanini J Fernando Arevalo Maurício Maia | 2013 | World Journal of Diabetes2013，4，2： | 18 |
| 11 | Gastroesophageal reflux disease:From pathophysiology to treatment显示文摘This review focuses on the pathophysiology of gastroesophageal reflux disease (GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett’s esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GERD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GERD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GERD. | Fernando A Herbella Marco G Patti | 2010 | World Journal of Gastroenterology2010，16，30： | 18 |
| 12 | Nocardia infections among immunomodulated inflammatory bowel disease patients:A review显示文摘Human nocardiosis,caused by Nocardia spp.,an ubiquitous soil-borne bacteria,is a rare granulomatous disease close related to immune dysfunctions.Clinically can occur as an acute life-threatening disease,with lung,brain and skin being commonly affected.The infection was classically diagnosed in HIV infected persons,organ transplanted recipients and long term corticosteroid treated patients.Currently the widespread use of immunomodulators and immunossupressors in the treatment of inflammatory diseases changed this scenario.Our purpose is to review all published cases of nocardiosis in immunomodulated patients due to inflammatory diseases and describe clinical and laboratory findings.We reviewed the literature concerning human cases of nocardiosis published between 1980 and 2014 in peer reviewed journals.Eleven cases of nocardiosis associated with anti-tumor necrosis factor(TNF) prescription(9 related with infliximab and 2 with adalimumab) were identified; 7 patients had inflammatory bowel disease(IBD),4 had rheumatological conditions; nocardia infection presented as cutaneous involvement in 3 patients,lung disease in 4 patients,hepatic in one and disseminated disease in 3 patients.From the 10 cases described in IBD patients 7 were associated with anti-TNF and 3 with steroids and azathioprine.In conclusion,nocardiosis requires high levels of clinical suspicion and experience of laboratory staff,in order to establish a timely diagnosis and by doing so avoid worst outcomes.Treatment for long periods tailored by the susceptibility of the isolated species whenever possible is essential.The safety of restarting immunomodulators or anti-TNF after the disease or the value of prophylaxis with cotrimoxazole is still debated. | Candida Abreu Nuno Rocha-Pereira António Sarmento Fernando Magro | 2015 | World Journal of Gastroenterology2015，21，21： | 18 |
| 13 | Clinical trials on corticosteroids for diabetic macular edema显示文摘Diabetic macular edema(DME)is a common cause of visual impairment in diabetic patients.It is caused by an increase in the permeability of the perifoveal capillaries and a disruption of the blood retinal-barrier.The pathogenesis of DME is multifactorial.Several therapeutic modalities have been proposed for the treatment of DME.Corticosteroid treatments have emerged as an alternative therapy for persistent DME or refractory to conventional laser photocoagulation and other modalities,due to anti-inflammatory,anti-vascular endothelial growth factor and anti-proliferative effects.Many studies have demonstrated the beneficial therapeutic effect of corticosteroids with improvement to both retinal thickness and visual acuity in short-term on the treatment of DME.Peribulbar and intravitreal injections have been used to deliver steroids for DME with frequent injections due to the chronic and recurrent nature of the disease.Steroid-related side effects include elevated intraocular pressure,cataract,and injection related complications such as endophthalmitis,vitreous hemorrhage,and retinal detachment particularly with intravitreal steroid injections.In order to reduce the risks,complications and frequent dosing of intravitreal steroids,intravitreal implants have been developed recently to provide sustained release of corticosteroids and reduce repeated intravitreal injections for the management of DME. | Hassan A Al Dhibi J Fernando Arevalo | 2013 | World Journal of Diabetes2013，4，6： | 17 |
| 14 | The Arabidopsis thaliana HAK5 K+ Transporter Is Required for Plant Growth and K+ Acquisition from Low K+ Solutions under Saline Conditions显示文摘在集中和它的部件的高亲密关系的范围的 K+ 举起广泛地被学习了。在 Arabidposis thaliana, AtHAK5 transporter 和 AtAKT1 隧道被显示了是涉及这个过程的主要运输蛋白质。这里,我们在二个重要压力条件下面学习这二个系统的角色:低 K+ 供应或咸度的存在。破坏 AtHAK5 和 AtAKT1 的 T-DNA 插入线为允许变异的线的生理的描述的长期的实验被采用。我们发现 AtHAK5 为必要的 K+ 吸收被要求在缺席以及面对咸度在低 K+ 支撑植物生长。咸度极大地减少了 AtHAK5 抄本层次并且支持了调停 AtAKT1 的 K+ 流出,导致 K+ 营养的一个重要缺陷。尽管有一个有限能力, AtHAK5 面对咸度从低 K+ 集中为 K+ 获得起一个主要作用。 | Manuel Nieves-Cordones Fernando Aleman Vicente Martinez Francisco Rubio | 2010 | Molecular Plant2010，3，2： | 17 |
| 15 | Non-steroidal anti-inflammatory drugs:What is the actual risk of liver damage?显示文摘Non-steroidal anti-inflammatory drugs (NSAIDs) constitute a family of drugs, which taken as a group, represents one of the most frequently prescribed around the world. Thus, not surprisingly NSAIDs, along with antiinfectious agents, list on the top for causes of DrugInduced Liver Injury (DILI). The incidence of liver disease induced by NSAIDs reported in clinical studies is fairly uniform ranging from 0.29/100 000 [95% confidence interval (CI): 0.17-051] to 9/100 000 (95% CI: 6-15). However, compared with these results, a higher risk of liver-related hospitalizations was reported (3-23 per 100 000 patients). NSAIDs exhibit a broad spectrum of liver damage ranging from asymptomatic, transient, hyper-transaminasemia to fulminant hepatic failure. However, under-reporting of asymptomatic, mild cases, as well as of those with transient liver-tests alteration, in conjunction with reports non-compliant with pharmacovigilance criteria to ascertain DILI and flawed epidemiological studies, jeopardize the chance to ascertain the actual risk of NSAIDs hepatotoxicity. Several NSAIDs, namely bromfenac, ibufenac and benoxaprofen, have been withdrawn from the market due to hepatotoxicity; others like nimesulide were never marketed in some countries and withdrawn in others. Indeed, the contro-versy concerning the actual risk of severe liver disease persists within NSAIDs research. The present work intends (1) to provide a critical analysis of the dissimilar results currently available in the literature concerning the epidemiology of NSAIDS hepatotoxicity; and (2) to review the risk of hepatotoxicity for each one of the most commonly employed compounds of the NSAIDs family, based on past and recently published data. | Fernando Bessone | 2010 | World Journal of Gastroenterology2010，16，45： | 16 |
| 16 | 犊牛营养与管理对其终生生产性能的影响显示文摘犊牛在断奶前阶段的生长发育会发生显著变化,这一过程直接关系到犊牛在未来第一个以及随后泌乳期的生产性能。断奶前犊牛的生长速度和基础蛋白质沉积可能是提高终生产奶量的关键因素,任何影响犊牛断奶前采食量和生长速度的因素都会影响产奶量。在营养供给方面,能量和蛋白质都很重要,尤其是蛋白质的品质和可消化性。在断奶之前,液体饲料更能提高犊牛的潜在生产性能。除了初乳中免疫球蛋白之外,还有一些因素能够影响犊牛的采食量、饲料效率和生长发育状况,并且可以改善早期的营养状况对后期的影响。营养师需要讨论代谢能、蛋白摄入量以及与维持有关的状况,而不是讨论干物质、牛奶、代乳粉等具体数量。犊牛有其自身独特的营养需要,这与测定的干物质和液体饲料体积无关。犊牛人工饲养比其自然生长的效果好。断奶前阶段可以通过改善犊牛的生长性能来发挥其遗传潜能。 | Mike Van Amburgh Fernando Soberon 曹志军 黄鸿威 史伟娜 苏华维 | 2016 | 中国奶牛2016，，2： | 16 |
| 17 | Effects of cold and warm cross-rolling on microstructure and texture evolution of AZ31B magnesium alloy sheet显示文摘Mg alloys conventionally rolled often present strong basal textures that affect negatively further deformations,limiting their applications.The present research found that cross-rolling experiences in adequate conditions can weaken those intense basal textures as a result of the interaction of deformation mechanisms and dynamic recrystallization.The effects of rolling temperature and strain rate on the microstructure and texture of an AZ31B magnesium alloy sheet generated heterogeneous microstructure where the initial basal texture was strengthened during cold cross-rolling and it was gradually weakening by the rolling reduction and the rolling temperature increases in such a way that a rather weak basal fiber was produced applying reductions higher than 15%at temperatures higher than 200℃.Their ODF functions supported the texture weakening,exhibiting a combination of two crystallographic orientations represented by{0001}<211^(-)0>and{0001}<101^(-)0>. | Litzy Lina Choquechambi Catorceno Hamilton Ferreira Gomes de Abreu Angelo Fernando Padilha | 2018 | Journal of Magnesium and Alloys2018，6，2： | 16 |
| 18 | A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases显示文摘Iron deficiency (ID), with or without anemia, is often caused by digestive diseases and should always be investigated, except in very specific situations, as its causes could be serious diseases, such as cancer. Diagnosis of ID is not always easy. Low serum levels of ferritin or transferrin saturation, imply a situation of absolute or functional ID. It is sometimes difficult to differentiate ID anemia from anemia of chronic diseases, which can coexist. In this case, other parameters, such as soluble transferrin receptor activity can be very useful. After an initial evaluation by clinical history, urine analysis, and serological tests for celiac disease, gastroscopy and colonoscopy are the key diagnostic tools for investigating the origin of ID, and will detect the most important and prevalent diseases. If both tests are normal and anemia is not severe, treatment with oral iron can be indicated, along with stopping any treatment with non-steroidal anti-inflammatory drugs. In the absence of response to oral iron, or if the anemia is severe or clinical suspicion of important disease persists, we must insist on diagnostic evaluation. Repeat endoscopic studies should be considered in many cases and if both still show normal results, investigating the small bowel must be considered. The main techniques in this case are capsule endoscopy, followed by enteroscopy. | Fernando Bermejo Santiago García-López | 2009 | World Journal of Gastroenterology2009，15，37： | 14 |
| 19 | Cardiovascular autonomic neuropathy in diabetes:Pathophysiology,clinical assessment and implications显示文摘Cardiovascular autonomic neuropathy(CAN)is a debilitating condition that mainly occurs in long-standing type 2 diabetes patients but can manifest earlier,even before diabetes is diagnosed.CAN is a microvascular complication that results from lesions of the sympathetic and parasympathetic nerve fibers,which innervate the heart and blood vessels and promote alterations in cardiovascular autonomic control.The entire mechanism is still not elucidated,but several aspects of the pathophysiology of CAN have already been described,such as the production of advanced glycation end products,reactive oxygen species,nuclear factor kappa B,and pro-inflammatory cytokines.This microvascular complication is an important risk factor for silent myocardial ischemia,chronic kidney disease,myocardial dysfunction,major cardiovascular events,cardiac arrhythmias,and sudden death.It has also been suggested that,compared to other traditional cardiovascular risk factors,CAN progression may have a greater impact on cardiovascular disease development.However,CAN might be subclinical for several years,and a late diagnosis increases the mortality risk.The duration of the transition period from the subclinical to clinical stage remains unknown,but the progression of CAN is associated with a poor prognosis.Several tests can be used for CAN diagnosis,such as heart rate variability(HRV),cardiovascular autonomic reflex tests,and myocardial scintigraphy.Currently,it has already been described that CAN could be detected even during the subclinical stage through a reduction in HRV,which is a non-invasive test with a lower operating cost.Therefore,considering that diabetes mellitus is a global epidemic and that diabetic neuropathy is the most common chronic complication of diabetes,the early identification and treatment of CAN could be a key point to mitigate the morbidity and mortality associated with this long-lasting condition. | Alice Duque Mauro Felippe Felix Mediano Andrea De Lorenzo Luiz Fernando Rodrigues Jr | 2021 | World Journal of Diabetes2021，12，6： | 14 |
| 20 | Extraintestinal manifestations of inflammatory bowel disease:Do they influence treatment and outcome?显示文摘Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases that often involve organs other than those of the gastrointestinal tract. Immune-related extraintestinal manifestations (EIMs) are usually related to disease activity, but sometimes may take an independent course. Globally, about one third of patients develop these systemic manifestations. Phenotypic classification shows that certain subsets of patients are more susceptible to developing EIMs, which frequently occur simultaneously in the same patient overlapping joints, skin, mouth, and eyes. The clinical spectrum of these manifestations varies from mild transitory to very severe lesions, sometimes more incapacitating than the intestinal disease itself. The great majority of these EIMs accompany the activity of intestinal disease and patients run a higher risk of a severe clinical course. For most of the inflammatory EIMs, the primary therapeutic target remains the bowel. Early aggressive therapy can minimize severe complications and maintenance treatment has the potential to prevent some devastating consequences. | Fernando Tavarela Veloso | 2011 | World Journal of Gastroenterology2011，17，22： | 13 |
您所在的机构暂未开通此部分的功能，请联系管理员