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8篇 您的检索式：作者名="Gondy L"

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		题名	作者	年代	出处	被引量
	1	Therapeutic options for the management of pancreatic cancer显示文摘Since its initial characterization, pancreatic ductal adenocarcinoma has remained one of the most devastating and difficult cancers to treat. Pancreatic cancer is the fourth leading cause of death in the United States, resulting in an estimated 38460 deaths annually. With few screening tools available to detect this disease at an early stage, 94% of patients will die within five years of diagnosis. Despite decades of research that have led to a better understanding of the molecular and cellular signaling pathways in pancreatic cancer cells, few effective therapies have been developed to target these pathways. Other treatment options have included more sophisticated pancreatic cancer surgeries and combination therapies. While outcomes have improved modestly for these patients, more effective treatmentsare desperately needed. One of the greatest challenges in the future of treating this malignancy will be to develop therapies that target the tumor microenvironment and surrounding pancreatic cancer stem cells in addition to pancreatic cancer cells. Recent advances in targeting pancreatic stellate cells and the stroma have encouraged researchers to shift their focus to the role of desmoplasia in pancreatic cancer pathobiology in the hopes of developing newer-generation therapies. By combining novel agents with current cytotoxic chemotherapies and radiation therapy and personalizing them to each patient based on specific biomarkers, the goal of prolonging a patient's life could be achieved. Here we review the most effective therapies that have been used for the treatment of pancreatic cancer and discuss the future potential of therapeutic options.	Maria L Rossi Azeem A Rehman Christopher S Gondi	2014	World Journal of Gastroenterology2014，20，32：	13
	2	Transfection with anti - p65 intrabody suppresses invasion and angiogenesis in Glioma ceils by blocking nuclear factor - KB transcriptional activity显示文摘	Li L Gondi CS Dinh DH	2007	Clin Cancer Res2007，13，7：	1
	3	Transfection with anti-p65 intrabody suppresses invasion and angiogenesis in glioma cells by blocking nuclear factor-kappaB transcriptional activity显示文摘	Li L Gondi CS Dinh DH	2007	Glin Cancer Res2007，13，7：	1
	4	Insulin-like growth factorⅠgene transfer to cirrhotic liver induces fibrolysis and reduces fibrogenesis leading to cirrhosis reversion in rats显示文摘	Sobrevals L Rodriguez C Romero-Trevejo JL Gondi G Monreal I Paeda A	2010	Hepatology2010，51，3：	1
	5	Transfeetion with anti-p65 intrabody suppresses invasion and angiogenesis in glioma cells by blocking nuclear factor-kappaB transcriptional activity 显示文摘	LI L GONDI C S DINH D H	2007	Clin Cancer Res2007，13，7：	1
	6	Adenovirus-mediated expression of ntisense MMP-9 in glioma cells inhibits tumor groweth and invasion 显示文摘	L akka S S najan M Gondi C	2002	Oneogene2002，21，：	1
	7	Transfection with anti-p65 intrabody suppresses invasion and angiogenesis in glioma cells by blocking nuclear factor-kappaB transcriptional activity显示文摘	Li L Gondi CS Dinh DH	2007	Clin Cancer Res2007，13，：	1
	8	Genescene : An Ontology-Enhanced Integration of Linguistic and Co-Occurrence Based Relations in Biomedical Texts 显示文摘	Gondy L Hsinchun C	2005	Journal of the American Society for in Information Science and Technology2005，56，5：	1

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