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| 1 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 2 | JWA regulates melanoma metastasis by integrin alpha(V)beta(3) signaling(摘要)显示文摘 | Bai, J Zhang, J Wu, J Shen, L Zeng, J Ding, J Wu, Y Gong, Z Li, A Xu, S Zhou, J Li, G | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 3 | A geomorphological response of beaches to Typhoon Meari in the eastern Shandong Peninsula in China显示文摘Eight representative beach profiles on the eastern coast of the Shandong Peninsula are observed and measured in2011 and 2012 to determine the coastal processes under the lower tropical wind speed condition and the beach response to and recovery from the tropical storm Meari in a rare typhoon region. The results show that it is the enhancement and directional change of cross-shore and longshore sediment transports caused by Meari that leads to the beach morphological changes, and most of the sediment transports occur during the pre-Meari landing phase. The erosional scarp formation and the berm or beach face erosion are the main geomorphological responses of the beaches to the storm. The storm characteristics are more important than the beach shapes in the storm response process of the beaches on Shandong Peninsula. The typhoon is a fortuitous strong dynamic event,and the effect on the dissipative beach is more obvious than it is on the reflective beach in the study region.Furthermore, the beach trend is the main factor that controlls the storm effect intensity, and it is also closely related to the recovery of the beach profiles. | DING Dong YANG Jichao LI Guangxue DADA Olusegun A GONG Lixin WANG Nan WANG Xiangdong ZHANG Bin | 2015 | Acta Oceanologica Sinica2015，34，9： | 4 |
| 4 | Influence of precipitation on the Portevin-Le Chatelier effect in Al-Mg alloys显示文摘In the alloy with solute content higher than the limiting solubility,the solute atoms that have failed to dissolve will precipitate from the solid solution and form precipitations.In this study, the Portevin-Le Chatelier(PLC) effects in annealed 5456 and 5052 aluminum alloys with different precipitation contents have been investigated under different applied strain rates.The results suggest that precipitations have significant effect on the PLC effect and the more the precipitations are, the greater the ... | Qi Hu,~(a))Qingchuan Zhang,~(b)) Shihua Fu,Pengtao Cao,and Ming Gong CAS Key Laboratory of Mechanical Behavior and Design of Materials,University of Science and Technology of China,Hefei 230027,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，1： | 3 |
| 5 | Position and Velocity Estimation Via Bearings-only Observations 显示文摘 | Lindgren A G Gong K F | 1978 | IEEE Transactions on Aerospace and Electronic Systems1978，14，4： | 3 |
| 6 | A regional ionospheric TEC mapping technique over China and adjacent areas: GNSS data processing and DINEOF analysis显示文摘A technique is developed to derive two-dimensional maps of total electron content(TEC) over China and adjacent areas using Global Navigation Satellite System(GNSS) data from the Crustal Movement Observation Network of China(CMONOC) and the International Global Navigation Satellite System Service(IGS). A revised self-calibration of pseudo-range errors(SCORE) algorithm is used to derive the TEC and to determine the Differential Code Biases(DCBs) simultaneously. The accuracy and validity of this technique is verified in two ways. Firstly, the estimated TEC is compared with the results derived using DCBs from Center for Orbit Determination of Europe(CODE) under different solar activity conditions and seasons; secondly, sample TEC along the receiver-to-satellite ray paths are simulated by Ne Quick model and are reprocessed by this TEC derivation technique to make the accuracy test. Two-dimensional maps of vertical TEC of ionospheric pierce points(IPPs) are obtained accordingly with a time resolution of 30 s. The data interpolating empirical orthogonal functions(DINEOF) technique is then used to make the extrapolation for the unknown or missing data points. The optimal EOF modes for data reconstruction are specified via cross-validation method. The regional TEC distribution over China and adjacent areas is scaled into grid size of 1? × 1? for each 5 min, which can well reflect the characteristic of large-scale regional variations and temporal evolution as well as the small-scale local features of ionosphere. | A Ercha HUANG WenGeng LIU SiQing SHI LiQin GONG JianCun CHEN YanHong SHEN Hua | 2015 | Science China(Information Sciences)2015，58，10： | 3 |
| 7 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 8 | Studies on fluorenscence resonance energy transfer between CdS nanoparticles and DOCAI dyes显示文摘The water-soluble CdS nanoparticles were synthesized in aqueous solution. A novel fluorescence resonance energy transfer (FRET) system with CdS nanoparticles as energy donors and 3,30-diethyl-oxadicarbocyanine iodide (DOCAI) dyes as energy accepter has been developed. | Lun Wang Yan Liu Hong Qi Chen A Ni Liang Fa Gong Xu | 2007 | Chinese Chemical Letters2007，18，3： | 2 |
| 9 | Recurrent acute liver failure associated with novel SCYL1 mutation:A case report显示文摘BACKGROUND Pediatric recurrent acute liver failure(RALF) with recovery between episodes is rare. Causes include autoimmune disease, which may flare and subside;intermittent exposure to toxins, as with ingestions; and metabolic disorders,among them the fever-associated crises ascribed to biallelic mutations in SCYL1,with RALF beginning in infancy. SCYL1 disease manifest with RALF, as known to date, includes central and peripheral neurologic and muscular morbidity(hepatocerebellar neuropathy syndrome). Primary ventilatory and skeletal diseases also have been noted in some reports.CASE SUMMARY We describe a Han Chinese boy in whom fever-associated RALF began at age 14 mo. Bilateral femoral head abnormalities and mild impairment of neurologic function were first noted aged 8 years 6 mo. Liver biopsy after the third RALF episode(7 years) and during resolution of the fourth RALF episode(8 years 6 mo) found abnormal architecture and hepatic fibrosis, respectively. Whole-exome sequencing revealed homozygosity for the novel frameshift mutation c.92_93 insGGGCCCT, p.(H32 Gfs~*20) in SCYL1(parental heterozygosity confirmed).CONCLUSION Our findings expand the mutational and clinical spectrum of SCYL1 disease. In our patient a substantial neurologic component was lacking and skeletal disease was identified relatively late. | Jia-Qi Li Jing-Yu Gong A S Knisely Mei-Hong Zhang Jian-She Wang | 2019 | World Journal of Clinical Cases2019，7，4： | 2 |
| 10 | Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats显示文摘BACKGROUND Sulongga-4(SL-4)is a herbal formula used in traditional Mongolian medical clinics for the treatment of peptic ulcers and gastroenteritis,even though its pharmacological mechanism has not been well characterized.AIM To evaluate the protective effect and identify the mechanisms of action of SL-4 on gastroduodenal ulcer induced by pyloric ligation(PL)in rats.METHODS PL was performed to induce gastric and duodenal ulcers in rats,which were then treated with oral SL-4(1.3,2.6,or 3.9 g/kg per day)for 15 d.PL-induced gastroduodenal ulceration.Therapeutic effects were characterized by pathological and histological evaluations and inflammatory indicators were analyzed by enzyme-linked immunosorbent assay.Microarray analyses were conducted to identify gene expression profiles of gastroduodenal tissue in PL rats with or without SL-4 treatment.The candidate target genes were selected and verified by quantitative reverse transcription polymerase chain reaction(qRT-PCR).RESULTS SL-4 decreased histopathological features in the PL-induced ulcerated rats.SL-4 significantly (P < 0.05) decreased expression of tumor necrosis factor-α,interleukin (IL)-1β, IL-6, endotoxin, platelet-activating factor, and increasedprostaglandin E2 and epidermal growth factor in ulcer tissue. Microarray analysiswas used to identify a panel of candidate target genes for SL-4 acting on PLinducedulceration. Genes included some complement and coagulation cascadeand retinol metabolism pathways that are closely associated with inflammatoryresponses and gastric mucosal protective mechanisms. qRT-PCR showed thataltered expression of the selected genes, such as CYP2b2, UGT2b1, A2m, andMASP1 was consistent with the microarray results.CONCLUSIONSL-4 exerts protective effects against PL-induced gastroduodenal ulcers viareducing inflammatory cytokines and elevating expression of gastric acidinhibitory factors. Downregulation of CYP2b2 and UGT2b1 genes in retinolmetabolism and upregulation of A2m and MASP1 genes in the complement andcoagulation cascades pathways are possibly involved in SL-4-mediated protectionagainst gastroduodenal ulcer. | Shan Tong Huan Wang Li-Sha A Ta-Na Bai Ju-Hua Gong Wen-Jie Jin Li-Li Dai Gen-Na Ba Sung-Bo Cho Ming-Hai Fu | 2021 | World Journal of Gastroenterology2021，27，16： | 2 |
| 11 | Titanium oxide nanotube arrays prepared by anodic oxidation 显示文摘 | Gong D W Grimes C A Varghese O K | 2001 | J Mater Res2001，16，12： | 1 |
| 12 | Behavior and design of reinforced concrete, steel, and steel-concrete coupling beams显示文摘 | KENT A HARRIES M EERI BINGNIAN GONG BAHRAM M SHAHROOZ | 2000 | Earthquake Spectra2000，16，4： | 1 |
| 13 | Distinct stages of cytochrome c release from mitochondria:evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis显示文摘 | Chen Q Gong B Almasan A | 2000 | Cell Death Differ2000，7，2： | 1 |
| 14 | Heat shock proteins and cancer vaccines: developments in the past decade and chap- eroning in the decade to come显示文摘 | Murshid A Gong J Stevenson MA | 2011 | Expert Rev Vaccines2011，10，11： | 1 |
| 15 | The emerging role of circulating tumor cell detection in genitourinary cancer显示文摘 | SMALL A GONG CY OH WK | 2012 | J Urol2012，188，1： | 1 |
| 16 | Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes显示文摘 | Gong A Y Pamela S T Melissa A M | 2003 | Am J Cell Physiol2003，25，6： | 1 |
| 17 | Fundamental properties and performance of conventional bearings-only target motion analysis显示文摘 | Nardone S C Lindgren A Gong K | 1984 | IEEE Trans on Automatic Control1984，29，9： | 1 |
| 18 | Defect physics of the kesterite thin-film solar cell absorber Cu2ZnSnS4显示文摘 | Chen S Gong X Walsh A | 2010 | Applied Physics Letters2010，96，02： | 1 |
| 19 | Crystal and electronic band structure of Cu2 ZnSnX4 (X = S and Se)photovoltaic absorbers : first-principles insights 显示文摘 | CHEN S GONG X G WALSH A | 2009 | Appl Phys Lett2009，94，04： | 1 |
| 20 | Joint bandwidth and power allocation with admission control in wireless multi-user networks with and without relaying 显示文摘 | GONG X VOROBYOV S A TELLAMBURA C | 2011 | IEEE Transactions on Signal Processing2011，59，4： | 1 |
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