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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Recombinant Newcastle disease virus expressing African swine fever virus protein 72 is safe and immunogenic in mice显示文摘African swine fever(ASF) is a lethal hemorrhagic disease that affects wild and domestic swine. The etiological agent of ASF is African swine fever virus(ASFV). Since the first case was described in Kenya in 1921, the disease has spread to many other countries. No commercial vaccines are available to prevent ASF. In this study, we generated a recombinant Newcastle disease virus(r NDV) expressing ASFV protein 72(p72) by reverse genetics and evaluated its humoral and cellular immunogenicity in a mouse model. The recombinant virus, r NDV/p72, replicated well in embryonated chicken eggs and was safe to use in chicks and mice. The p72 gene in r NDV/p72 was stably maintained through ten passages. Mice immunized with r NDV/p72 developed high titers of ASFV p72 specific Ig G antibody, and had higher levels of Ig G1 than IgG2 a. Immunization also elicited T-cell proliferation and secretion of IFN-γ and IL-4. Taken together, these results indicate that r NDV expressing ASFV p72 might be a potential vaccine candidate for preventing ASF. | Xinxin Chen Jifei Yang Yanhong Ji Edward Okoth Bin Liu Xiaoyang Li Hong Yin Qiyun Zhu | 2016 | Virologica Sinica2016，31，2： | 18 |
| 3 | Graphene-based Li-ion hybrid supercapacitors with ultrahigh performance显示文摘有一个成长要求让混合 supercapacitor 系统克服存在产生的精力密度限制电的双层电容器(EDLC ) ,在力量与最小的牺牲导致下 generation-II supercapacitors 密度和周期生活。这里,一个先进基于 graphene 的混合系统,由插入 graphene 的 Li4Ti5O12 (LTO ) 组成合成阳极(G-LTO ) 和三维的多孔的 graphene 蔗糖阴极,为两个都联合 Li 离子电池(精力来源) 和 supercapacitors (力量来源) 的好处的目的被制作了。基于 Graphene 的材料关于混合 supercapacitor 的高效在两个电极起一个重要作用。例如,与 175 | Kai Leng Fan Zhang Long Zhang Tengfei Zhang Yingpeng Wu Yanhong Lu Yi Huang Yongsheng Chen | 2013 | Nano Research2013，6，8： | 15 |
| 4 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 5 | Comparison of cancer incidence and mortality in three GDP per capita levels in China, 2013显示文摘Objective:In this research,the patterns of cancer incidence and mortality in areas with different gross domestic product per capita(GDPPC)levels in China were explored,using data from population-based cancer registries in 2013,collected by the National Central Cancer Registry(NCCR).Methods:Data from 255 cancer registries were qualified and included in this analysis.Based on the GDPPC data of 2014,cities/counties were divided into 3 levels:high-,middle-and low-GDPPC areas,with 40,000 and 80,000 RMB per year as cut points.We calculated cancer incidences and mortalities in these three levels,stratified by gender and age group.The national population of the Fifth Census in 2000 and Segi’s population were applied for age-standardized rates.Results:The crude incidence and mortality rates as well as age-standardized incidence rate(ASIR)showed positive associations with GDPPC level.The age-standardized mortality rate(ASMR)nevertheless showed a negative association with GDPPC level.The ASMR in high-,middle-and low-GDPPC areas was 103.12/100,000,112.49/100,000 and 117.43/100,000,respectively.Lung cancer was by far the most common cancer in all three GDPPC levels.It was also the leading cause of cancer death,regardless of gender and GDPPC level.Negative associations with GDPPC level were found for the ASIRs of lung,stomach,esophageal and liver cancer,whereas colorectal and breast cancer showed positive associations.Except for breast cancer,the ASMRs of the other five cancers were always higher in middle-and low-GDPPC areas than in high-GDPPC areas.Conclusions:The economic development is one of the main factors of the heavy cancer burden on Chinese population.It would be reasonable to implement cancer control strategies referring to the local GDPPC level. | Zhixun Yang Rongshou Zheng Siwei Zhang Hongmei Zeng Changfa Xia He Li Li Wang Yanhong Wang Wanqing Chen | 2017 | Chinese Journal of Cancer Research2017，29，5： | 13 |
| 6 | Estimation of aboveground biomass using in situ hyperspectral measurements in five major grassland ecosystems on the Tibetan Plateau显示文摘Aims There are numerous grassland ecosystem types on the Tibetan Plateau.These include the alpine meadow and steppe and degraded alpine meadow and steppe.This study aimed at developing a method to estimate aboveground biomass(AGB)for these grasslands from hyperspectral data and to explore the feasibility of applying air/satellite-borne remote sensing techniques to AGB estimation at larger scales.Methods We carried out a field survey to collect hyperspectral reflectance and AGB for five major grassland ecosystems on the Tibetan Plateau and calculated seven narrow-band vegetation indices and the vegetation index based on universal pattern decomposition(VIUPD)from the spectra to estimate AGB.First,we investigated correlations between AGB and each of these vegetation indices to identify the best estimator of AGB for each ecosystem type.Next,we estimated AGB for the five pooled ecosystem types by developing models containing dummy variables.At last,we compared the predictions of simple regression models and the models containing dummy variables to seek an ecosystem type-independent model to improve prediction of AGB for these various grassland ecosystems from hyperspectral measurements.Important findings When we considered each ecosystem type separately,all eight vegetation indices provided good estimates of AGB,with the best predictor of AGB varying among different ecosystems.When AGB of all the five ecosystems was estimated together using a simple linear model,VIUPD showed the lowest prediction error among the eight vegetation indices.The regression models containing dummy variables predicted AGB with higher accuracy than the simple models,which could be attributed to the dummy variables accounting for the effects of ecosystem type on the relationship between AGB and vegetation index(VI).These results suggest that VIUPD is the best predictor of AGB among simple regression models.Moreover,both VIUPD and the soil-adjusted VI could provide accurate estimates of AGB with dummy variables integrated in regression models.Therefore,ground-based hyperspectral measurements are useful for estimating AGB,which indicates the potential of applying satellite/airborne remote sensing techniques to AGB estimation of these grasslands on the Tibetan Plateau. | Miaogen Shen Yanhong Tang Julia Klein Pengcheng Zhang Song Gu Ayako Shimono Jin Chen | 2008 | Journal of Plant Ecology2008，1，4： | 10 |
| 7 | Phylogenetic constrains on mycorrhizal specificity in eight Dendrobium(Orchidaceae) species显示文摘Plant phylogeny constrains orchid mycorrhizal(OrM) fungal community composition in some orchids. Here, we investigated the structures of the OrM fungal communities of eight Dendrobium species in one niche to determine whether similarities in the OrM fungal communities correlated with the phylogeny of the host plants and whether the Dendrobium-OrM fungal interactions are phylogenetically conserved. A phylogeny based on DNA data was constructed for the eight coexisting Dendrobium species,and the OrM fungal communities were characterized by their roots. There were 31 different fungal lineages associated with the eight Dendrobium species. In total, 82.98% of the identified associations belonging to Tulasnellaceae, and a smaller proportion involved members of the unknown Basidiomycota(9.67%). Community analyses revealed that phylogenetically related Dendrobium tended to interact with a similar set of Tulasnellaceae fungi. The interactions between Dendrobium and Tulasnellaceae fungi were significantly influenced by the phylogenetic relationships among the Dendrobium species. Our results provide evidence that the mycorrhizal specificity in the eight coexisting Dendrobium species was phylogenetically conserved. | Xiaoke Xing Xueting Ma Jinxin Men Yanhong Chen Shunxing Guo | 2017 | Science China(Life Sciences)2017，60，5： | 10 |
| 8 | Carbon foam with microporous structure for high performance symmetric potassium dual-ion capacitor显示文摘A novel carbon foam with microporous structure(CFMS),with the advantages of a simple fabrication process,low energy consumption,large specific surface area and high conductivity,has been prepared by a facile one-step carbonization.In addition,the carbon foam possesses suitable interlayer spacing in short range which is flexible to accommodate the deformation of carbon layer caused by the ion insertion and deinsertion at the charge and discharge state.Furthermore,a low cost carbon-based symmetric potassium dual-ion capacitor(PDIC),which integrates the virtues of potassium ion capacitors and dual-ion batteries,is successfully established with CFMS as both the battery-type cathode and the capacitor-type anode.PDIC displays a superior rate performance,an ultra-long cycle life(90%retention after 10000 cycles),and a high power density of 7800 W kg^-1 at an energy density of 39Whkg^-1.The PDIC also exhibits excellent ultrafast charge and slow discharge properties,with a full charge in just 60 s and a discharge time of more than 3000 s. | Yanhong Feng Suhua Chen Jue Wang Bingan Lu | 2020 | Journal of Energy Chemistry2020，29，4： | 10 |
| 9 | SOME EXTENDED KNAPSACK PROBLEMS INVOLVING JOB PARTITION BETWEEN TWO PARTIES显示文摘一些新奇应用;背囊问题(KP ) 的实用变化被介绍;构造了,它被提出;从以二人的分离合作游戏从工作的分区在利润分配上在这篇论文开始的一个模型发展了。 | Gu Yanhong Chen Quanle | 2007 | Applied Mathematics(A Journal of Chinese Universities)2007，22，3： | 8 |
| 10 | Strong ozone production at a rural site in the North China Plain: Mixed effects of urban plumes and biogenic emissions显示文摘Regional ozone(O_3) pollution has drawn increasing attention in China over the recent decade, but the contributions from urban pollution and biogenic emissions have not been clearly elucidated. To better understand the formation of the regional O_3 problem in the North China Plain(NCP), intensive field measurements of O_3 and related parameters were conducted at a rural site downwind of Ji'nan, the capital city of Shandong province, in the summer of 2013. Markedly severe O_3 pollution was recorded, with the O_3 mixing ratios exceeding the Chinese national ambient air quality standard on 28 days(a frequency of 78%) and with a maximum hourly value of 198 ppbv. Extensive regional transport of wellprocessed urban plumes to the site was identified. An observation-constrained chemical box model was deployed to evaluate in situ photochemical O_3 production on two episodes.The results show that the in situ formation accounted for approximately 46% of the observed O_3 accumulation, while the remainder(~54%) was contributed by regional transport of the O_3-laden urban plumes. The in situ ozone production was in a mixed controlled regime that reducing either NOx or VOCs would lead to a reduction of ozone formation. Biogenic VOCs played an important role in the local ozone formation. This study demonstrates the significant mixed effects of both anthropogenic pollution from urban zones and biogenic emission in rural areas on the regional O_3 pollution in the NCP region,and may have general applicability in facilitating the understanding of the formation of secondary pollution over China. | Ruihan Zong Xue Yang Liang Wen Caihong Xu Yanhong Zhu Tianshu Chen Lan Yao Liwei Wang Junmei Zhang Lingxiao Yang Xinfeng Wang Min Shao Tong Zhu Likun Xue Wenxing Wang | 2018 | Journal of Environmental Sciences2018，30，9： | 8 |
| 11 | Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity显示文摘Photonic sensors that are able to detect and track biochemical molecules offer powerful tools for information acquisition in applications ranging from environmental analysis to medical diagnosis.The ultimate aim of biochemical sensing is to achieve both quantitative sensitivity and selectivity.As atomically thick films with remarkable optoelectronic tunability,graphene and its derived materials have shown unique potential as a chemically tunable platform for sensing,thus enabling significant performance enhancement,versatile functionalization and flexible device integration.Here,we demonstrate a partially reduced graphene oxide(prGO)inner-coated and fiber-calibrated Fabry-Perot dye resonator for biochemical detection.Versatile functionalization in the prGO film enables the intracavity fluorescent resonance energy transfer(FRET)to be chemically selective in the visible band.Moreover,by measuring the intermode interference via noise canceled beat notes and locked-in heterodyne detection with Hz-level precision,we achieved individual molecule sensitivity for dopamine,nicotine and single-strand DNA detection.This work combines atomic-layer nanoscience and high-resolution optoelectronics,providing a way toward high-performance biochemical sensors and systems. | Zhongxu Cao Baicheng Yao Chenye Qin Run Yang Yanhong Guo Yufeng Zhang Yu Wu Lei Bi Yuanfu Chen Zhenda Xie Gangding Peng Shu-Wei Huang Chee Wei Wong Yunjiang Rao | 2019 | Light(Science & Applications)2019，8，1： | 8 |
| 12 | Urban Expansion and Its Influencing Factors in Natural Wetland Distribution Area in Fuzhou City,China显示文摘This paper principally focuses on land use dynamics,urban expansion and underlying driving forces in the Natural Wetland Distribution Area(NWDA)of Fuzhou City in the southeastern China.Based on time series Landsat TM/ETM+imageries and historical data,relationships between urban land expansion and its influencing factors from 1989 to 2009 were analyzed by using an integrated approach of remote sensing(RS)and geographic information system(GIS)techniques.The results showed that built-up land increased from 151.16 km2in 1989 to 383.76 km 2in 2009. Approximately 64.25%of the newly emerging built-up land was converted from cropland(29.47%),forest and shrub (25.78%),water(3.73%),wetland(4.61%),and bare land(0.66%)during 1989 and 2009.With a remarkable decrease in cropland,the proportion of non-agricultural population increased by 23.6%.Moreover,rapid development of infrastructures,facilities,industrial parks,and urban and rural settlements along the Minjiang River resulted in the eastward and southward expansion of built-up land.Additionally,the growth pattern of built-up land in the NWDA is highly correlated with socio-economic factors,including the gross domestic product(GDP),GDP per capita,and structure of industry.As a result,the observed environmental degradation such as loss of cropland and wetland due to heavy pressure of rapid urbanization have greatly impaired the carrying capacity of city.Thus,in addition to scientific and rational policies towards minimizing the adverse effects of urbanization,coordination between the administrative agencies should be urgently strengthened to balance the conflicts between urban development and ecological conservation to make sure the sustainable land use. | CAI Yuanbin ZHANG Hao PAN Wenbin CHEN Yanhong WANG Xiangrong | 2012 | Chinese Geographical Science2012，22，5： | 8 |
| 13 | Expert consensus on dental caries management显示文摘Dental Caries is a kind of chronic oral disease that greatly threaten human being’s health.Though dentists and researchers struggled for decades to combat this oral disease,the incidence and prevalence of dental caries remain quite high.Therefore,improving the disease management is a key issue for the whole population and life cycle management of dental caries.So clinical difficulty assessment system of caries prevention and management is established based on dental caries diagnosis and classification.Dentists should perform oral examination and establish dental records at each visit.When treatment plan is made on the base of caries risk assessment and carious lesion activity,we need to work out patient-centered and personalized treatment planning to regain oral microecological balance,to control caries progression and to restore the structure and function of the carious teeth.And the follow-up visits are made based on personalized caries management.This expert consensus mainly discusses caries risk assessment,caries treatment difficulty assessment and dental caries treatment plan,which are the most important parts of caries management in the whole life cycle. | Lei Cheng Lu Zhang Lin Yue Junqi Ling Mingwen Fan Deqin Yang Zhengwei Huang Yumei Niu Jianguo Liu Jin Zhao Yanhong Li Bin Guo Zhi Chen Xuedong Zhou | 2022 | International Journal of Oral Science2022，14，2： | 8 |
| 14 | Stratigraphy of the Triassic-Jurassic Boundary Successions of the Southern Margin of the Junggar Basin,Northwestern China显示文摘The Triassic-Jurassic(Tr-J) boundary marks a major extinction event,which(~200 Ma) resulted in global extinctions of fauna and flora both in the marine and terrestrial realms.There prevail great challenges in determining the exact location of the terrestrial Tr-J boundary,because of endemism of taxa and the scarcity of fossils in terrestrial settings leading to difficulties in linking marine and terrestrial sedimentary successions.Investigation based on palynology and bivalves has been carried out over a 1113 m thick section,which is subdivided into 132 beds,along the Haojiagou valley on the southern margin of the Junggar Basin of the northern Xinjiang,northwestern China.The terrestrial Lower Jurassic is conformably resting on the Upper Triassic strata.The Upper Triassic covers the Huangshanjie Formation overlaid by the Haojiagou Formation,while the Lower Jurassic comprises the Badaowan Formation followed by the Sangonghe Formation.Fifty six pollen and spore taxa and one algal taxon were identified from the sediments.Based on the key-species and abundance of spores and pollen,three zones were erected:the Late Triassic(Rhaetian) Aratrisporites-Alisporites Assemblage,the Early Jurassic(Hettangian) Perinopollenites-Pinuspollenites Assemblage,and the Sinemurian Perinopollenites-Cycadopites Assemblage.The Tr-J boundary is placed between bed 44 and 45 coincident with the boundary between the Haojiagou and Badaowan formations.Beds with Ferganoconcha(?),Unio-Ferganoconcha and Waagenoperna-Yananoconcha bivalve assemblages are recognized.The Ferganoconcha(?) bed is limited to the upper Haojiagou Formation, Unio-Ferganoconcha and Waagenoperna-Yananoconcha assemblages are present in the middle and upper members of the Badaowan Formation.The sedimentary succession is interpreted as terrestrial with two mainly lake deposit intervals within Haojiagou and Badaowan formations,yielding fresh water algae and bivalves.However,the presence of brackish water algae Tasmanites and the marine-littoral facies bivalve Waagenoperna from the Badaowan Formation indicate that the Junggar Basin was influenced by sea water caused by transgressions from the northern Tethys,during the Sinemurian. | SHA Jingeng Vivi VAJDA PAN Yanhong Linda LARSSON YAO Xiaogang ZHANG Xiaolin WANG Yaqiong CHENG Xiansheng JIANG Baoyu DENG Shenghui CHEN Siwei PENG Bo | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 7 |
| 15 | Origin of Listwanite in the Luobusa Ophiolite,Tibet,Implications for Chromite Stability in Hydrothermal Systems显示文摘Listwanite from the Luobusa ophiolite,Tibet,forms a narrow,discontinuous band along the eastern part of the southern boundary fault. We undertook a detailed petrographic and geochemical study to understand the mineral transformation processes and the behaviour of major and trace elements during listwanite formation. Three alteration zones characterized by distinct mineral components and texture are recognized and,in order of increasing degree of alteration,these are: zoneIII is rich in serpentine minerals; zoneII is rich in talc and carbonates; and zoneI is mainly composed of carbonates and quartz. Geochemical data for the three alteration zones show significant modification of some major and trace elements in the protolith,although some oxides show linear correlations with Mg O. Gold mineralization is recognized in the Luobusa listwanite and may signify an important target for future mineral exploration. Gold enrichment occurs in both zoneI and zoneIIand is up to 0.91 g/t in one sample from zoneI. We show that CO2-rich hydrothermal fluids can modify both the occurrence and composition of chromite grains,indicating some degree of chromite mobility. Low-Cr anhedral grains are more easily altered than high-Cr varieties. The compositions of chromite and olivine grains in the listwanite suggest a dunite protolith. | ZHANG Lan YANG Jingsui Paul T.ROBINSON XIONG Fahui CHEN Yanhong LAI Shengmin CHEN Mei | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 6 |
| 16 | Progress in electrochemical lithium ion pumping for lithium recovery显示文摘Accelerating the development of lithium resources has attracted a great deal of attention with the explosive growth of new energy vehicles.As a new technology,electrochemical lithium ion pumping(ELIP)is featured by environment-friendly,low energy consumption and high efficiency.This review summarizes the research progress in ELIP,and focuses on the evaluation methods,electrode materials and electrochemical systems of ELIP.It can be concluded that ELIP is expected to achieve an industrial application and has a promising prospect.In addition,challenges and perspective of electrochemical lithium extraction are also highlighted. | Guolang Zhou Linlin Chen Yanhong Chao Xiaowei Li Guiling Luo Wenshuai Zhu | 2021 | Journal of Energy Chemistry2021，30，8： | 6 |
| 17 | Mycorrhizal fungal community composition in seven orchid species inhabiting Song Mountain, Beijing, China显示文摘Mycorrhizal fungi play an important role in the germination and growth of orchids essentially influencing their survival,abundance, and spatial distribution. In this study, we investigated the composition of the mycorrhizal fungal community in seven terrestrial orchid species inhabiting Song Mountain, Beijing, China, using Illumina MiSeq high-throughput sequencing. The mycorrhizal communities in the seven orchids were mainly composed of members of the Ceratobasidiaceae, Sebacinales, and Tulasnellaceae, while a number of ectomycorrhizal fungi belonging to the Russulaceae, Tricholomataceae, Thelephoraceae, and Cortinariaceae were occasionally observed. However, the dominant fungal associates and mycorrhizal community differed significantly among the orchid species as well as subhabitats. These findings confirm the previous observation that sympatric orchid species show different preferences for mycorrhizal fungi, which may drive niche partitioning and contribute to their cooccurrence. | Yanhong Chen Yue Gao Linli Song Zeyu Zhao Shunxing Guo Xiaoke Xing | 2019 | Science China(Life Sciences)2019，62，6： | 6 |
| 18 | Experimental Investigation of the Effect of the Material Damage Induced in Sheet Metal Forming Process on the Service Performance of 22MnB5 Steel显示文摘The use of ultra-high strength steels through sheet metal forming process offers a practical solution to the lightweight design of vehicles.However,sheet metal forming process not only produces desirable changes in material properties but also causes material damage that may adversely influence the service performance of the material formed.Thus,an investigation is conducted to experimentally quantify such influence for a commonly used steel(the 22MnB5 steel) based on the hot and cold forming processes.For each process,a number of samples are used to conduct a uniaxial tensile test to simulate the forming process.After that,some of the samples are trimmed into a standard shape and then uniaxially extended until fracture to simulate the service stage.Finally,a microstructure test is conducted to analyze the microdefects of the remaining samples.Based on the results of the first two tests,the effect of material damage on the service performance of 22MnB5 steel is analyzed.It is found that the material damages of both the hot and cold forming processes cause reductions in the service performance,such as the failure strain,the ultimate stress,the capacity of energy absorption and the ratio of residual strain.The reductions are generally lower and non-linear in the former process but higher and linear in the latter process.Additionally,it is found from the microstructure analysis that the difference in the reductions of the service performance of 22MnB5 by the two forming processes is driven by the difference in the micro damage mechanisms of the two processes.The findings of this research provide a useful reference in terms of the selection of sheet metal forming processes and the determination of forming parameters for 22MnB5. | ZHUANG Weimin XIE Dongxuan CHEN Yanhong | 2016 | Chinese Journal of Mechanical Engineering2016，29，4： | 6 |
| 19 | Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering显示文摘Pure collagen is biocompatible but lacks inherent osteoinductive,osteoimmunomodulatory and antibacterial activities.To obtain collagen with these characteristics,we developed a novel methodology of doping bioactive elements into collagen through the synchronous self-assembly/mineralization(SSM)of collagen.In the SSM model,amorphous mineral nanoparticles(AMN)(amorphous SrCO3,amorphous Ag3PO4,etc.)stabilized by the polyampholyte,carboxymethyl chitosan(CMC),and collagen molecules were the primary components under acidic conditions.As the pH gradually increased,intrafibrillar mineralization occurred via the self-adaptive interaction between the AMNs and the collagen microfibrils,which were self-assembling;the AMNs wrapped around the microfibrils became situated in the gap zones of collagen and finally transformed into crystals.Srdoped collagen scaffolds(Sr-CS)promoted in vitro cell proliferation and osteogenic differentiation of rat bone marrow mesenchymal stromal cells(rBMSCs)and synergistically improved osteogenesis of rBMSCs by altering the macrophage response.Ag-doped collagen scaffolds(Ag-CS)exhibited in vitro antibacterial effects on S.aureus,as well as cell/tissue compatibility.Moreover,Sr-CS implanted into the calvarial defect of a rat resulted in improved bone regeneration.Therefore,the SSM model is a de novo synthetic strategy for doping bioactive elements into collagen,and can be used to fabricate multifunctional collagen scaffolds to meet the clinical challenges of encouraging osteogenesis,boosting the immune response and fighting severe infection in bone defects. | Huanhuan Liu Mingli Lin Xue Liu Ye Zhang Yuyu Luo Yanyun Pang Haitao Chen Dongwang Zhu Xue Zhong Shiqing Ma Yanhong Zhao Qiang Yang Xu Zhang | 2020 | Bioactive Materials2020，5，4： | 6 |
| 20 | Geochronology and Geochemistry of the Subduction-related Rocks with High Sr/Y Ratios in the Zedong Area: Implications for the Magmatism in Southern Lhasa Terrane during Late Cretaceous显示文摘南部的拉萨岩层以它在中生代和新生代期间记录 magmatism 的巨大的 magmatic 带著名。尽管在南部的拉萨岩层的中生代大陆人边缘背景被识别了,在迟了的白垩纪期间的这构造设定和进化历史的细节仍然保持不清楚。为了推进,抑制这些问题,我们现在的锆石 LA-ICP-MS U-Pb,同位素的 Hf 和 Sangri 的 Gongbari dacites 的 geochemical 数据组织哪个从南部的拉萨岩层的东方部分由古新的 granodiorites 侵入了,西藏。新年龄数据显示 dacites 在 ∼95.4 妈被产生,它建议 Sangri 组火山作用可以持续到迟了的白垩纪。Gongbari dacites 被高 Sr 428-758 ppm 内容描绘,例如 Yb=0.78-1.14 ppm 的重稀土元素元素和 Y 的低集中;有高 Sr/Y 41.91-67.59 和 La/Yb 22.64-30.64 比率的 Y=8.85-11.4 ppm,类似于那些 adakite。岩石是计算碱的, metaluminous,在 LILE 充实,在 HFSE 弄空,并且有积极 ε Hf t 价值 +7.7 到 +11.6。Gongbari dacites 被到石榴石角闪岩外形条件的在角闪岩下面的年轻、热的 subducted Neo-Tethyan 海洋的外壳的部分融化可能生产。尽管 Gangdese 山可能形成了以前 Indo 亚洲的碰撞,拉萨岩层的南部的边缘可能不通过显然外壳的变厚在期间向北方 Neo-Tethyan 的 subduction 海洋的岩石圈。 | CHEN Yanhong YANG Jingsui XIONG Fahui ZHANG Lan LAI Shengmin CHEN Mei | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 6 |
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