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您的检索式：作者名="Gong Zhenping"
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| 1 | Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration显示文摘The previous investigation has proved that their existed pharmacokinetic difference between the different crystal forms of the polymorphic drugs after oral administration.However,no systemic investigations have been made on the change of this pharmacokinetic difference,resulted either from the physiological or from the pathological factors.In this paper,we used polymorphic nimodipine(Nim) as a model drug and investigated the effect of age difference(2- and 9-month old) on the pharmacokinetics after oral delivery in rats.As the results shown,for L-form of Nim(L-Nim),the AUC0–24 hin 2-month-old rats was 343.68747.15 ng h/m L,which is 23.36% higher than that in 9-month-old rats.For H-form of Nim(H-Nim),the AUC0–24 hin 2-monthold rats was 140.91719.47 ng h/m L,which is 54.64% higher than that in 9-month-old rats.The AUC0–24 h ratio between H-Nim and L-Nim was 2.44 in 2-month-old rats and 3.06 in 9-month-old rats.Since age difference could result in unparallelled change of the absorption and bioavailability of the polymorphic drugs,the results in this experiment are of value for further investigation of crystal form selection in clinical trials and rational clinical application of the polymorphic drugs. | Wenli Liu Xiaona Wang Ruilian Chen Kaixuan Zhang Yao Li Yi Li Duanyun Si Junbo Gong Dianshu Yin Yongli Wang Zhenping Wei Mingshi Yang | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 3 |
| 2 | Regularity of Nitrogen Accumulation in Soybean and Its Simulation显示文摘Nitrogen(N) is considered as an important yield and quality-determining factor in soybean production.The objective of the current experiment was to determine the regularity of N accumulation and its simulation among different varieties.This work was conducted with frame tests(pot without bottom),and three cultivars,HH41,SN14,HN40,and one feed soybean variety MSD was used as materials.The results showed that the regularity of N accumulation in four varieties with the same tendency increased during the whole growth period,which was up to the maximum when the plant was harvested.The longer growth period was,the higher N accumulation of cultivars was,HN40>SN14>HH41,N accumulation of MSD was the highest because of the property for feed soybean.Regularity of N accumulation in plants could be accurately described by the Logistic equation.During the growth there was a period when N accumulation in the whole plant occurred at an intense rate.The time of onset and its duration varied with different varieties.The maximum daily N accumulation was on seed filling stage,pod bearing stage,seed filling stage and pod bearing stage in HH41,SN14,HN40 and MSD,respectively. | YAO Yubo JIN Xijun DI Wei GE Huiling MA Chunmei GONG Zhenping | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，1： | 2 |
| 3 | Analysis of isozymes and RAPD for mutagenic propenies induced by space environment in Sorghum 显示文摘 | LIU Genqi Gong Zhenping LIU Chunguang | 2002 | Developmental & Reproductive Biology2002，1，4： | 1 |
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