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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Nitric-oxide-directed synaptie remodeling in the adult mamml CNS 显示文摘 | Sunieo C R Portillo F Gonzalez Forero D | 2005 | Neuroscience2005，25，6： | 1 |
| 3 | Use of Kraft black liquors from a pulp mill for the production of soil conditioners 显示文摘 | Alvarez R Coca J | 1992 | Water Air and Soil Pollution1992，61，： | 1 |
| 4 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 5 | Instrumental and expert assessment of Mahon cheese texture显示文摘 | Benedito J Gonzalez R Rossello C | 2000 | Journal of Food Science2000，65，7： | 1 |
| 6 | Safety,tolerbility,and immunogenicity of a two-dose regimen of high-titer varicella vaccine in subjects≥13 years of age显示文摘 | DIAZ C DENTICO P GONZALEZ R | 2006 | Vaccine2006，24，4748： | 1 |
| 7 | Dosimetric characterization of a new preparation of BaSOa activated by Eu ions显示文摘 | GONZALEZ P R FURETTA C CALVO B E GASO M I CRUZ-ZARAGOZA E | 2007 | Nucl Instrum Meth B2007，260，： | 1 |
| 8 | Modes of operation and pH control as enhancement factors for partial nitrification with oxygen transport limitation 显示文摘 | Ciudad G Gonzalez R Bornhardt C | | Water Research 20970，41，20： | 1 |
| 9 | Modes of operation and pH control as enhancement factors for partial nitrification with oxygen transport limitation显示文摘 | CIUDAD G GONZALEZ R BORNHARDT C | 2007 | Water Research2007，41，20： | 1 |
| 10 | Simultaneous immunoaffinity column clean-up and HPLC analysis of aflatoxins and ochratoxin A in Spanish bee pollen显示文摘 | Garcia-Villanova R J Cordon C Gonzalez Paramas A M | 2004 | J Agric Food Chem2004，52，124： | 1 |
| 11 | Decreased circulating endothelial progenitor ceils as an early risk factor of subclinical atherosclerosis in systemic lupus erythematosus显示文摘 | Castejon R Jimenez - Ortiz C Valero - Gonzalez S | 2014 | Rheumatology2014，53，4： | 1 |
| 12 | Kietic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins显示文摘 | TORMO J R GONZALEZ M C CORTES D | 1999 | Arch Biochem Biophys1999，369，1： | 1 |
| 13 | Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats显示文摘 | Gonzalez R Rodriguez S Romay C | 1999 | Pharmacol Res1999，39，： | 1 |
| 14 | Expression of WUSCHEL in Coffea canephora causes ectopic morphogenesis and increases somatic embryogene- sis显示文摘 | Arroyo - Herrera A Gonzalez A K Moo R C | 2008 | Plant Cell Tissue and Organ Culture2008，94，2： | 1 |
| 15 | Effect of urea treatment on chemical composition and digestion of Cenchrus ciliaris and Cynodon dactylon Hays and Zea mays residues 显示文摘 | Ramirez G R Aguilera - Gonzalez J C Garcia - Diaz G | 2007 | Journal of Animal and Veterinary Advances2007，6，8： | 1 |
| 16 | Zinc supplementation decreases hepatic copper accumulation in LEC rat: A model of Wilson' s disease 显示文摘 | Gonzalez B P Nino Fong R Gibson C J | 2005 | Biol Trace Elem Res2005，105，11： | 1 |
| 17 | The use of multisensor data for robotic applications显示文摘 | Abidi M A Gonzalez R C | 1990 | IEEE Transactions on Robotics and Automation1990，6，： | 1 |
| 18 | The use of multi-sensor data for robotic Application 显示文摘 | Abidi M A Gonzalez R C | 1990 | IEEE Transactions on Robotics and Automation1990，6，2： | 1 |
| 19 | Effects of water stress on antioxidant enzymes of leaves and nod- ules of transgenic alfalfa overexpressing superoxide dis- mutases 显示文摘 | Rubio M C Gonzalez E M Minchin F R | 2002 | Physiol Plant2002，115，： | 1 |
| 20 | The methanol oxidation reaedon on platinum alloys with the first row transition metals:The case of Pt-Co and-Ni alloy eleetroeatalysts for DMFCs:A short review显示文摘 | Antolini E Salgodo J R C Gonzalez E R | 2006 | Applied Catalysis B:Environmental2006，63，： | 1 |
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