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| 1 | Pancreatic cancer serum biomarker PC-594:Diagnostic performance and comparison to CA19-9显示文摘AIM:To investigate serum PC-594 fatty acid levels as a potential biomarker in North American pancreatic cancer(PaC) patients,and to compare its performance to CA19-9.METHODS:Using tandem mass spectrometry,we evaluated serum PC-594 levels from 84 North American patients with confirmed PaC and 99 cancer-free control subjects.We determined CA19-9 levels by ELISA.Significance between Pa C patients and controls,and association with clinical variables was determined by analysis of variance and t-tests.Diagnostic performance was evaluated by receiver-operator characteristic(ROC)curve analysis,and PC-594 correlation with age and CA19-9 determined by regression analysis.RESULTS:Mean PC-594 levels were 3.7 times lower in Pa C patients compared to controls(P < 0.0001).The mean level in PaC patient serum was 0.76 ± 0.07 μmol/L,and the mean level in control subjects was 2.79 ± 0.15 μmol/L.There was no correlation between PC-594 and age,disease stage or gender(P > 0.05).Using 1.25 μmol/L as a PC-594 threshold produced a relative risk(RR) of 9.4(P < 0.0001,95%CI:5.0-17.7).The area under the receiver-operator characteristic curve(ROCAUC) was 0.93(95%CI:0.91-0.95) for PC-594 and 0.85(95%CI:0.82-0.88) for CA19-9.Sensitivity at 90% specificity was 87% for PC-594 and 71% for CA19-9.Six Pa C patients with CA19-9 above 35 U/m L showed normal PC-594 levels,while 24 Pa C patients with normal CA19-9 showed low PC-594 levels.Eighty-five of the 99 control subjects(86%) showed normal levels of both markers.CONCLUSION:PC-594 biomarker levels are significantly reduced in North American Pa C patients,and showed superior diagnostic performance compared to CA19-9. | Shawn A Ritchie Bassirou Chitou Qingan Zheng Dushmanthi Jayasinghe Wei Jin Asuka Mochizuki Dayan B Goodenowe | 2015 | World Journal of Gastroenterology2015，21，21： | 3 |
| 2 | Peripheral ethanol amine plasmalogen deficiency:a logical causative factor in Alzheimer's disease and dementia显示文摘 | Goodenowe DB Cook LL Liu J et at | 2007 | J Lipid Res2007，48，11： | 1 |
| 3 | Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana显示文摘 | Hirai MY Yano M Goodenowe DB | 2004 | PNAS2004，101，10： | 1 |
| 4 | Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy显示文摘 | Mark A Wallet Carina A Rodriguez Li Yin Sara Saporta Sasawan Chinratanapisit Wei Hou John W Sleasman Maureen M Goodenow | 2010 | AIDS2010，，： | 1 |
| 5 | Ab Initio Prediction of Metabolic Networks using Fourier Transform Mass Spectrometry Data显示文摘 | BREITLING R RITCHIE S GOODENOWE D | 2006 | Metabolomics2006，2，： | 1 |
| 6 | Classroombelonging among early adolescent students显示文摘 | Goodenow C | 1993 | Journal of early adolescent1993，，13： | 1 |
| 7 | Thepsychological sense of school member- ship among adolescents:Scale development and educational coirelates显示文摘 | Goodenow C | 1993 | Psychological in the schools1993，，30： | 1 |
| 8 | A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi ) genotypes: discovery of novel compounds 显示文摘 | Murch S J Rupasinghe H PV Goodenowe D | 2004 | Plant Cell Rep2004，23，： | 1 |
| 9 | SLE nephritis is associated with an oligoclonal expansion of intrarenal T ceils 显示文摘 | Massengill S F Goodenow M M Sleasman J W | 1998 | Am J Kidney Dis1998，31，3： | 1 |
| 10 | The relationship of school belonging and friends' values 显示文摘 | Goodenow C Grady K E | 1993 | Journal of Experimental Education1993，62，1： | 1 |
| 11 | Strengthening the links between educational psychology and the study of social contexts显示文摘 | Goodenow C | | 0，，2： | 1 |
| 12 | A metabolomic analy- sis of medicinal diversity in Huang - qin( Scutellaria baicalensis Geor- gi) genotypes : discovery of novel compounds显示文摘 | Murch S J Rupasinghe H P Goodenowe D | 2004 | Plant Cell Rep2004，23，6： | 1 |
| 13 | Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana显示文摘 | HIRAI M Y YANO M GOODENOWE D B | 2004 | Proc Natl Acad Sci USA2004，101，10： | 1 |
| 14 | The psychological sense of school membership among adolescents:Scale development and educational correlates显示文摘 | Goodenow C | 1993 | Psychology in the Schools1993，30，1： | 1 |
| 15 | Classroom belonging among early adolescent students:Relationship to motivation and achievement显示文摘 | Goodenow C | | 0，，13： | 1 |
| 16 | The relationship of school belonging and friends’values to academic motivation among urban adolescent students显示文摘 | Goodenow C Grady K E | 1993 | The Journal of Experimental Education1993，62，1： | 1 |
| 17 | The psychological sense of school member-ship among adolescents: Scale development and educational correlates显示文摘 | Goodenow C | 1993 | Psychology in the Schools1993，，1： | 1 |
| 18 | Classroom belonging among early adolescent students: Relationship to motivation and achievement显示文摘 | Goodenow C | 1993 | Journal of early adolescence1993，，13： | 1 |
| 19 | Leukocytosis and artifactual hypoglycemia显示文摘 | Goodenow T J Malarkey WB | | 0，，08： | 1 |
| 20 | Relation of plasmalo- gens,ApoE genotype,and Alzheimer' s disease pathology to cogni- tion : A post-mortem analysis 显示文摘 | Goodenowe DB Senanayake V Chitou B | 2015 | Alzheimer'' s & Dementia2015，11，7： | 1 |
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