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| 1 | Ent-11α-Hydroxy-15-oxo-kaur-16-en-19-oic-acid Inhibits Growth of Human Lung Cancer A549 Cells by Arresting Cell Cycle and Triggering Apoptosis显示文摘Objective: To examine the apoptotic effect of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), a compound isolated from Pteris semipinnata L (PsL), in human lung cancer A549 cells. Methods: A549 cells were treated with 5F (0-80 μg/ml) for different time periods. Cytotoxicity was examined using a MTT method. Cell cycle was examined using propidium iodide staining. Apoptosis was examined using Hoechst 33258 staining, enzyme-linked immunosorbent assay (ELISA) and caspase-3 activity analysis. Expression of representative apoptosis-related proteins was evaluated by Western blot analysis. Reactive oxygen species (ROS) level was measured using standard protocols. Potential interaction of 5F with cisplatin was also examined. Results: 5F inhibited the proliferation of A549 cells in a concentration-and time-dependent manner. 5F increased the accumulation of cells in sub-G1 phase and arrested the cells in the G2 phase. Exposure to 5F induced morphological changes and DNA fragmentation that are characteristic of apoptosis. The expression of p21 was increased. 5F exposure also increased Bax expression, release of cytochrome c and apoptosis inducing factor (AIF), and activation of caspase-3. 5F significantly sensitized the cells to cisplatin toxicity. Interestingly, treatment with 5F did not increase ROS, but reduced ROS production induced by cisplatin. Conclusion: 5F could inhibit the proliferation of A549 cells by arresting the cells in G2 phase and by inducing mitochondrial-mediated apoptosis. | Li Li George G Chen Ying-nian Lu Yi Liu Ke-feng Wu Xian-ling Gong Zhan-ping Gou Ming-yue Li Nian-ci Liang | 2012 | Chinese Journal of Cancer Research2012，24，2： | 10 |
| 2 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 3 | Flutelike porous hematite nanorods and branched nanostructures:synthesis,characterisation and application for gas-sensing 显示文摘 | Gou X L Wang G X Yang J | 2008 | Chemistry-A European Journal2008，14，19： | 1 |
| 4 | Chemical synthesis, characterisation and gas sensing performance of copper oxide nanoribbons 显示文摘 | Gou X L Wang G X Yang J | 2008 | Journal of Materials Chemistry2008，，18： | 1 |
| 5 | Characteristics, development and mapping of Gossypium hirsutum derived EST-SSRs in allotetraploid cotton显示文摘 | HAN Z G WANG C B SONG X L GUO W Z GOU J Y LI C H CHEN X Y ZHANG T Z | 2006 | Theor Appl Genet2006，112，： | 1 |
| 6 | Research on plastic deformation behaviour in cold ring by FEM numerical simulation显示文摘 | Gou L G Yang H Zhan M | 2005 | Modeling and Simulation in Materials Science and Engineering2005，13，7： | 1 |
| 7 | The Nature of Radiative Transitions in O Doped Boron Nitride Nanotubes显示文摘 | Gou G Y Pan B C Shi L | 2009 | Journal of the American Chemical Society2009，131，48： | 1 |
| 8 | Ligand and pH-controlled ZnⅡ bilayer coordination polymers based on biphenyl-3,3',4,4'-tetracarboxylate显示文摘 | Wang J J Gou L Hu H M Han Z X Li D S Xue G L Yang M L Shi Q Z | | 0，，： | 1 |
| 9 | Nitrogen budget of a typical subterranean river in peak cluster karst area显示文摘 | Gou F Jiang G H | 2009 | Environment Geology2009，58，8： | 1 |
| 10 | Decor- in-mediated inhibition of colorectal cancer growth and migra- tion is associated with E-cadherin in vitro and in mice显示文摘 | Bi X Pohi NM Qian Z Yang GR Gou Y Guzman G | 2012 | Car- cinogenesis2012，33，2： | 1 |
| 11 | The draftgenome of a diploid cotton gossypium raimondii 显示文摘 | Kunbo Wang Zhiwen Wang Fuguang Li Wuwei Ye Junyi Wang Guoli Song Zhen Yue Lin Cong Haihong Shang Shilin Zhu Changsong Zou Qin Li Youlu Yuan Cairui Lu Hengling Wei Caiyun Gou Zequn Zheng Ye Yin Xueyan Zhang Kun Liu Bo Wang Chi Song Nan Shi Russell J Kohel Richard G Percy John Z Yu Yu-xian Zhu Jun Wang Shuxun Yu | 2012 | Nat Genet2012，，44： | 1 |
| 12 | Epigenetio modification of TLRs in leukocytes is associated with increased susceptibility to Salmonella enteritidis in chickens 显示文摘 | Gou Z Liu R Zhao G | 2012 | PLoS One2012，7，33： | 1 |
| 13 | An On-Grid Dynamic Multi-Timescale Method with Path Flux Analysis for Multi-Physics Detailed Modeling of Combustion显示文摘 | Ju Y G Gou X L Sun W T | 2009 | Journal of the Combustion of Japan2009，51，157： | 1 |
| 14 | Eukaryotic cytosine methyltrans-ferases显示文摘 | GoU M G Bestor T H | 2005 | Annu Rev Biochem2005，74，： | 1 |
| 15 | Synthesis and characterization of a water-soluble sulfonates copolymer of acrylamide and Nallylbenzamide as enhanced oil recovery chemical显示文摘 | Ye Z B Gou G J Gou S H | 2013 | Journal of Applied Polymer Science2013，128，3： | 1 |
| 16 | Antidepressant - like effects of tea poly- phenols on mouse model of chronic unpredictable mild stress 显示文摘 | Liu Y Jia G Gou L | 2013 | Pharmacol Biochem Behav2013，104，： | 1 |
| 17 | Nitrogen budget of a tipical subterranean riv er in peak cluster karst area显示文摘 | Gou F Jing G H | 2009 | Environmental Geology2009，58，8： | 1 |
| 18 | Quantum key distribution via quantum encryption显示文摘 | Zhang Y S Li C F Gou G C | 2001 | Phys Rev A2001，，02： | 1 |
| 19 | Large stokes shift induced by intramolcular charge transfer in N,O-chelated naphthyridine BF2 complexes 显示文摘 | Wu Y Y Chen Y Gou G Z etal | 2012 | Organic Letters2012，14，20： | 1 |
| 20 | Theoretical calculation of an- nular upward flow in a narrow annuli with bilateral heating 显示文摘 | SU G H GOU J L QIU S Z | 2003 | Nuclear Engineering and Design2003，225，23： | 1 |
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