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| 1 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 2 | Ecdysteroids and ovarian development in the shore crab,Carcinus maenas 显示文摘 | Lachaise F Goudeau M Hetru C | 1981 | Hoppe Seylers 2 Physiol Chem1981，362，5： | 1 |
| 3 | Characterisation of Ti1-xSixNy nanocomposite films显示文摘 | Vaz F Rebouta L Goudeau P | 2000 | Surface and Coatings Technology2000，，： | 1 |
| 4 | Criteria for emergency liver transplantation in patients with acute viral hepatitis and factor Ⅴ below 50% of: a prospective study 显示文摘 | Bernuau J Goudeau A Durand F | 1991 | Hepatology1991，14，4： | 1 |
| 5 | Robot-assisted laparoscopic myomectomy versus abdominal myomectomy: a comparison of short-term surgical outcomes and immedi- ate costs 显示文摘 | Advincula AP Xu X Goudeau S 4th | 2007 | J Minim Invasive Gynecol2007，14，6： | 1 |
| 6 | Characterization of Ti1-xSixNy nanocomposite films显示文摘 | Vaz F Rebouta L Goudeau P | 2000 | Surface and Coatings Technology2000，，： | 1 |
| 7 | Characterisation of Ti1-xSixNy nanocomposite films显示文摘 | Vaz F Rebouta L Goudeau P | 2000 | Surf Coat Techn2000，，： | 1 |
| 8 | Structural transitions in hard Si-based TiN coatings: the effect of bias voltage and temperature 显示文摘 | Vaz F Rebouta L Goudeau Ph | 2001 | Surf Coat Techn2001，，： | 1 |
| 9 | Fine structure and secretion of the capsule enclosing the embryo in a crab, Carcinus maenas 显示文摘 | Goudeau M Lachaise F | 1980 | Tissue Cell1980，12，1： | 1 |
| 10 | Structure of the egg funiculus and deposition of embryonic envdopes in a crab 显示文摘 | Goudeau M Lachaise F | 1983 | Tissue Cell1983，15，1： | 1 |
| 11 | Atomic force microscopy of in situ de-formed nickel films 显示文摘 | COUPEAU C NAUD J F CLEYMAND F GOUDEAU P GRILHE J | 1999 | Thin Solid Films1999，353，： | 1 |
| 12 | Multivariate analysis of prognosit ic factors in fulminant hepatitis B显示文摘 | Bernuau J Goudeau A Doynard T | 1986 | Hepatology1986，6，4： | 1 |
| 13 | An investigation on methanol catalytic synthesis from biomass gases显示文摘 | Goudeau Jean Claude Bourreau Main Souil Francois | 1983 | Energy Res1983，，3： | 1 |
| 14 | Characterisation of Ti1-xSixNy nanocomposite films显示文摘 | Vaz F Rebouta L Goudeau P | 2000 | Surf Coat Technol2000，，： | 1 |
| 15 | Improvement of the tribological behaviour of PVD nanostratified TiN/CrN coatings-An explanation显示文摘 | MENDIBIDE C STEYER P FONTAINE J GOUDEAU P | 2006 | Surface & Coatings Technology2006，201，7： | 1 |
| 16 | Cell signaling pathways toaB-crystallin following stresses of the cytoskeleton 显示文摘 | Nathalie Launay Bertrand Goudeau Kanefusa Kato | 2006 | Exp Cell Res2006，312，： | 1 |
| 17 | Fine structure and secretion of the capsule enclosing the embryo in a crab Carcininus maenas (L)显示文摘 | Goudeau M Lachaise F | 1980 | Tissue Cell1980，12，： | 1 |
| 18 | Myofibrillar myopathy with eongenital cataract and skeletal anomalies without mutations in the desmin, ctB-erystallin, myotilin, LMNA or SEPN1 genes 显示文摘 | Kostera-Peuszczyk A Goudeau B Femeiro A | 2006 | Neuromuscul Disord2006，16，11： | 1 |
| 19 | An investigation on methanol catalytic synthesis from biomass gases 显示文摘 | GOUDEAU JEAN CLAUDE BOURREAU ALAIN SOUIL FRANCOIS | 1983 | Energy RES1983，，3： | 1 |
| 20 | Systemic Free Radical Activation Is a Major Event Involved In Myocardial Oxidative Stress Related to Cardiopulmonary Bypass显示文摘 | Ga?lle Clermont Catherine Vergely Sa?d Jazayeri Jean-Jacques Lahet Jean-Jacques Goudeau Sandrine Lecour Michel David Luc Rochette Claude Girard | 2002 | Anesthesiology2002，，1： | 1 |
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