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| 1 | Implementation of a polling protocol for predicting celiac disease in videocapsule analysis显示文摘AIM: To investigate the presence of small intestinal villous atrophy in celiac disease patients from quantitative analysis of videocapsule image sequences.METHODS: Nine celiac patient data with biopsy-proven villous atrophy and seven control patient data lacking villous atrophy were used for analysis. Celiacs had biopsy-proven disease with scores of Marsh Ⅱ-Ⅲ C except in the case of one hemophiliac patient. At four small intestinal levels (duodenal bulb, distal duodenum, jejunum, and ileum), video clips of length 200 frames (100 s) were analyzed. Twenty-four measurements were used for image characterization. These measurements were determined by quantitatively processing the videocapsule images via techniques for texture analysis, motility estimation, volumetric reconstruction using shape-from-shading principles, and image transformation. Each automated measurement method, or automaton, was polled as to whether or not villous atrophy was present in the small intestine, indicating celiac disease. Each automaton's vote was determined based upon an optimized parameter threshold level, with the threshold levels being determined from prior data. A prediction of villous atrophy was made if it received the majority of votes (≥ 13), while no prediction was made for tie votes (12-12). Thus each set of images was classified as being from either a celiac disease patient or from a control patient. RESULTS: Separated by intestinal level, the overall sensitivity of automata polling for predicting villous atrophy and hence celiac disease was 83.9%, while the specificity was 92.9%, and the overall accuracy of automata-based polling was 88.1%. The method of image transformation yielded the highest sensitivity at 93.8%, while the method of texture analysis using subbands had the highest specificity at 76.0%. Similar results of prediction were observed at all four small intestinal locations, but there were more tie votes at location 4 (ileum). Incorrect prediction which reduced sensitivity occurred for two celiac patients with Marsh type Ⅱ pattern, which is characterized by crypt hyperplasia, but normal villous architecture. Pooled from all levels, there was a mean of 14.31 ± 3.28 automaton votes for celiac vs 9.67 ± 3.31 automaton votes for control when celiac patient data was analyzed (P<0.001). Pooled from all levels, there was a mean of 9.71 ± 2.8128 automaton votes for celiac vs 14.32 ± 2.7931 automaton votes for control when control patient data was analyzed (P<0.001). CONCLUSION: Automata-based polling may be useful to indicate presence of mucosal atrophy, indicative of celiac disease, across the entire small bowel, though this must be confirmed in a larger patient set. Since the method is quantitative and automated, it can potentially eliminate observer bias and enable the detectionof subtle abnormality in patients lacking a clear diagnosis. Our paradigm was found to be more efficacious at proximal small intestinal locations, which may suggest a greater presence and severity of villous atrophy at proximal as compared with distal locations. | Edward J Ciaccio Christina A Tennyson Govind Bhagat Suzanne K Lewis Peter H Green | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 3 |
| 2 | Delineation of a conserved B cell epitope on bonnet monkey (Macaca radiata) and human zona pellucida glycoprotein-B by monoclonal antibodies demonstrating inhibition of sperm-egg binding 显示文摘 | Govind CK Hasegawa A Koyama K | 2000 | Biol Reprod2000，62，1： | 1 |
| 3 | Adrenal Masses : MR imaging features with pathologic correlation 显示文摘 | Khakled ME Govind M Nan'a SL | 2004 | Radiographics2004，4，10： | 1 |
| 4 | The nucleotide sequence of the small subunit ribosomal RNA gene from Symbiodinium pilosum, a symbiotic dinoflagellate 显示文摘 | Sadler L A McNally K L Govind N S | 1992 | Curr Genet1992，21，： | 1 |
| 5 | Photochemical properties, composition, and structure in molecular beam epitaxy grown Fe 'doped' and (Fe,N) codoped rutile TiO2(ll0) 显示文摘 | MANGHAM A N GOVIND N BOWDEN M E | 2011 | J Phys Chem C2011，115，15： | 1 |
| 6 | Evidence that Clostridium difficile TcdC is a membrane-associated protein显示文摘 | Govind R Vediyappan G Rolfe R D Fralick J A | 2006 | J Bacteriol2006，188，： | 1 |
| 7 | Delineation of a conserved B ceil epitope on bonnet monkey (Macaca radiata ) and human zona pellucida glycoprotein-B by monoctonal anti bodies demonstrating inhibition of sperm-egg binding 显示文摘 | Govind C K Hasegawa A Koyama K | 2000 | Bi ology of Reproduction2000，62，1： | 1 |
| 8 | Clostridium difficile toxin synthesis is negatively regulated by TcdC显示文摘 | Dupuy B Govind R Antunes A | 2008 | J Med Microbiol2008，57，6： | 1 |
| 9 | Liver blood flow during cardiac surgery 显示文摘 | GOVIND C DAVID A C S JAY N | 2004 | Perfusion2004，19，： | 1 |
| 10 | Propagation induced polarization changes in partially coherent optical beams显示文摘 | GOVIND P A Wolf E | 2000 | JOSA A2000，17，11： | 1 |
| 11 | Maternal serum analytesas markers of adverse obstetric outcome显示文摘 | Lakhi N Govind A Moretti M | 2012 | Obstet Gynaecol2012，14，4： | 1 |
| 12 | Pulse broadening induced by dispersion fluctuations in optical fibers 显示文摘 | Lin Q Govind P A | 2002 | Optics Communications2002，206，： | 1 |
| 13 | An efficient feedback active noise control algorithm based on reduced-order linear predictive modeling of FMRI acoustic noise显示文摘 | Kannan Govind Milani All A Panahi Issa M S | 2011 | IEEE Transactions on Bio-Medical Engineering2011，8，12： | 1 |
| 14 | Phase-shifted fiber bragg gratings and their application forwavelength demultiplexing显示文摘 | GOVIND P A STOJAN R | 1994 | Photonics Technology Letters1994，6，8： | 1 |
| 15 | Nonlinear fiber optics: its history and recent progress显示文摘 | Govind P A | 2011 | J Opt Soc Ant B2011，28，12： | 1 |
| 16 | Polycystic ovaries are inher-ited as an autosomal dominant trait:analysis of 29 polycystic o-vary syndrome and 10 control families显示文摘 | Govind A Obhrai M S Clayton R N | 1999 | Journal of Clinical En-docrinology and Metabolism1999，84，1： | 1 |
| 17 | 显示文摘 | Andzelm J Govind N Maiti A | 2006 | Chemical Physics Letters2006，421，1： | 1 |
| 18 | Nanotube-based gas sensors-role of structural defects 显示文摘 | ANDZELM J GOVIND N MAITI A | 2006 | Chem Phys Lett2006，421，123： | 1 |
| 19 | Leaf area index measurements at Fluxnet-Canada forest sites显示文摘 | CHEN J M GOVIND A SONNENTAG O | 2006 | Agricultural and Forest Meteorology2006，140，： | 1 |
| 20 | Comparative evaluation of the sensitivity of LAMP, PCR and in vitro culture methods for the diagnosis of equine piroplasmosis显示文摘 | Alhassan A Govind Y Tam N T | 2007 | Parasitol Res2007，100，： | 1 |
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