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40篇 您的检索式:作者名="Grace A W"
    题名 作者 年代 出处 被引量
1Therapeutic potential of targeting the renin angiotensin system in portal hypertension显示文摘Portal hypertension is responsible for the bulk of the morbidity and mortality in patients with cirrhosis.Drug therapy to reduce portal pressure involves targeting two vascular beds.The first approach is to reduce intra hepatic vascular tone induced by the activity of powerful vasocontrictors such as angiotensin Ⅱ,endothelin-1 and the sympathetic system and mediated via contraction of perisinusoidal myofibroblasts and pervascular smooth muscle cells.The second approach is to reduce mesenteric and portal blood flow.Non-selective b-blockers are widely used and have been shown to prolong patient survival and reduce oesophageal variceal bleeding in advanced cirrhosis.However many patients are unable to tolerate these drugs and they are ineffective in a significant proportion of patients.Unfortunately there are no other drug therapies that have proven efficacy in the treatment of portal hypertension and prevention of variceal bleeding.This review briefly outlines current therapeutic approaches to themanagement of portal hypertension,and the evidence supporting the role of the renin angiotensin system(RAS) and the use of RAS blockers in this condition.It will also outline recent advances in RAS research that could lead to the development of new treatments focusing in particular on the recently discovered 'alternate axis' of the RAS.Chandana B Herath Josephine A Grace Peter W Angus 2013World Journal of Gastrointestinal Pathophysiology2013,4,1:9
2Hepatopulmonary syndrome: Update on recent advances in pathophysiology, investigation, and treatment显示文摘Josephine A Grace Peter W Angus 2013J Gastroenterol Hepatol2013,,2:2
3Post imaging temporomandibular joint space analysis显示文摘Kamelchuk L S Grace M G A Major P W 1996J Craniomandibular Pract1996,14,:1
4Strengthening of concrete beams using innovative ductile fiber-reinforced polymer fabric显示文摘Grace N F George A S Ragheb W F 2002ACI Struct J2002,99,5:1
5Synergy between conventional phosphorus fire retardants and organically-modified clays can lead to the fire retardancy of styrenics显示文摘Grace C Charles A W 2003Polymer Degradation and Stability2003,80,:1
6Potential net primary productivity in South America: Application of a global model 显示文摘 Rastetter E B Melillo J M Kicklighter D W Steudler P A Pteterson B J Grace A L Moore I B Vorosmarty C J 1991Ecological Applications1991,1,:1
7Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas显示文摘Michelle A Anderson Steven Carpenter Norman W Thompson Timothy T Nostrant Grace H Elta James M Scheiman 2000The American Journal of Gastroenterology2000,,9:1
8Rheological properties of white soft paraffin 显示文摘Barry B W Grace A J 1971Rheologica Acta1971,10,1:1
9Approximating the Tail of the An- derson-Darling Distribution 显示文摘Adam W Grace Ian A Wood 2012Computational Statisties & Data Analysis2012,5612,:1
10Duodenal PKC-[delta] and Cholecystokinin Signaling Axis Regulates Glucose Production显示文摘Breen Danna M Yue Jessica T Y Rasmussen Brittany A Kokorovic Andrea Cheung Grace W C Lam Tony K T 2011Diabetes2011,,12:1
11Returns to scale in the Eastern United States logging industry 显示文摘STUART W B GRACE L A GRALA R K 2010Forest Poli- cy and Economics2010,12,6:1
12Housing and the elderly in Singapore-Financial and quality of life implications of ageing in place 显示文摘KWAME A D GRACE K M W Journal of Housing and the Built Environment0,16,:1
13The evolution of aqeous cleaner technology显示文摘Joann A Quitmeger W R Grace 1995Metal Fishing1995,93,9:1
14Electroless Pd membrane deposition on alumina modified porous Hastelloy substrate with EDTA-free bath显示文摘RYI S K XU N LI A W LIM C J GRACE J R 2010International Journal of Hydrogen Energy2010,35,6:1
15Approximating the tail of the Anderson- Darling distribution显示文摘Grace A W Wood I A 2012Computational Statistics & Data Analy- sis2012,56,12:1
16Sensory testing of spreadability : Investigation of the rheological conditions operative during the application of topical preparations显示文摘Barry B W Grace A J 1972J Pharm Sci1972,61,:1
17Mercury in sediment and fish from North Mississippi lakes显示文摘Huggett D B Steevens J A Allgood J C Lutken C B Grace C A Benson W H 2001Chemosphere2001,42,8:1
18Preparation of thin Pd-based composite membrane on planar metallic substrate: Part I Pre-treatment of porous stainless steel substrate显示文摘LI A W R GRACE J LIM C J 2007Journal of Membrane Science2007,298,12:1
19Improved pre-treatment of porous stainless steel substrate for preparation of Pd-based composite membrane显示文摘XU N RYI S LI A W GRACE J R LIM J BOYD T 2013The Canadian Journal of Chemical Engineering2013,91,10:1
20Seasonal differences in foliar content of chlorogenic acid,a phenylpropanoid antioxidant,in Mahonia repens显示文摘Grace S C Logan B A Adams W W 1998Plant Cell and Environment1998,21,5:1
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