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| 1 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 2 | 查看详情显示文摘 | Chen S Cowan C F N Grant P M | | 0，，： | 2 |
| 3 | Fluconazole,a review of pharcodynamic and pharmacokinetic properties,and therapeutic potential in superficial and systemic mycoses显示文摘 | GRANT S M CLISSOLD S P | 1990 | Drugs1990，39，： | 1 |
| 4 | Orthogonal least squares learning algorithm for radiate basis function network显示文摘 | CHEN S COWAN C F N GRANT P M | 1991 | IEEE Transactions on Neural Network1991，2，2： | 1 |
| 5 | Age and size structure analysis of Engelmann spruce,population pine,Loadgepole,and Limber pine in cororado显示文摘 | Knowles P Grant M C | 1983 | Ecology1983，64，： | 1 |
| 6 | Recursive hybrid algorithm for non-linear system identification using radial basis function networks显示文摘 | Billings S A Grant P M | 1992 | Int J Control1992，55，5： | 1 |
| 7 | Orthogonal least squares learning algorithm for radial basis function networks显示文摘 | Chen S Cowan C F N Grant P M | 1991 | IEEE Transactions on Neural Networks1991，2，2： | 1 |
| 8 | Orthogonal Least Squares Learning Algorithm for Radial Basis Function Networks显示文摘 | Grant P M Cowan C F N | 1991 | IEEE Transaction on Neural Network1991，2，2： | 1 |
| 9 | Orthogonal least squares learning algorithm for radial basis function networks 显示文摘 | Chen S Cowan C F N Grant P M | 1991 | IEEE Transactions on Neural Networks1991，2，2： | 1 |
| 10 | Orthogonal Least Squares Learning Algorithm for Radial Basis Function Networks显示文摘 | Chen S Cowan C F N Grant P M | 1991 | IEEE Trans on Neural Network1991，2，2： | 1 |
| 11 | Effects of age and dietary restriction on oxidative DNA damage, antiox- idant protection and DNA repair in rats显示文摘 | Gedik C M Grant G Mortice P C | 2005 | European Journal of Nutrition2005，44，5： | 1 |
| 12 | The impact of short duration, high intensity exercise on cardiac troponin re- lease显示文摘 | GEORGE K P GRANT M C DAVIES B | 2014 | Clin Physiol Funct Imaging2014，，： | 1 |
| 13 | Transition metal based anticaneer drugs显示文摘 | Garbutcheon-Singh K B Grant M P Aldrich-Wright J R | 2011 | Curr Top Med Chem2011，，： | 1 |
| 14 | Determination of Amyose and Amylopectin of wheat Starch Using High Performance Sizeexelusion Chromatography(HPSEC) 显示文摘 | Grant L A Ostenson A M Rayas Duarte P | 2002 | Cereal Chemistry2002，79，6： | 1 |
| 15 | Smart antenna arrays for CDMA systems 显示文摘 | Thompson J S Grant P M Mulgrew B | 1996 | IEEE Personal Communications1996，3，5： | 1 |
| 16 | Age and size structure analysis of Engelmann spruce,population ponderosa pine, loadgepole pine,and limber pine in Coronado显示文摘 | Knowles P Grant M C | 1983 | Ecology1983，64，： | 1 |
| 17 | Orthogonal Least Square Learning Algorithm for Radial Basis Function Networks 显示文摘 | CHEN S COWAN C F N GRANT P M | 1991 | IEEE Trans on Neural Networks1991，2，2： | 1 |
| 18 | Functional expression of glucose-dependent insulinotropic polypeptide receptors is coupled to differentiation in a human adipocyte model显示文摘 | Weaver R E Donnelly D Wabitsch M Grant P J Balmforth A J | 2008 | Int J Obes ( Lond)2008，32，： | 1 |
| 19 | Orthogonal Least Squares Learning Algorithm for Radial Basis Function Networks显示文摘 | Grant P M Cowan C F N | 1991 | IEEE Transaction on Neural Network1991，2，2： | 1 |
| 20 | Rescursive Hybrid Algorithm for Nonlinear Identification Using Radial Basis Function Networks显示文摘 | Chen S Billings S A Grant P M | 1995 | International Journal of Control1995，55，5： | 1 |
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