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	题名	作者	年代	出处	被引量
1	Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms.	Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen	2007	World Journal of Gastroenterology2007，13，36：	8
2	Comparison of a High Saturated Fat Diet with a High Carbohydrate Diet During Pregnancy and Lactation: Effects on Insulin Sensitivity in Offspring of Rats显示文摘	Gregersen S Dyrskog SE Storlien LH	2005	Metabolism2005，54，10：	1
3	Alcohol and type 2 diabetes显示文摘	Pietraszek A Gregersen S Hermansen K	2010	Nutr metab Cardiovasc Dis2010，20，：	1
4	Stevioside induces antihyperglycaemic,insulinotropie and glueagonostatic effects in vivo:studies in the diabetic Goto-Kakizaki(GK) rats 显示文摘	Jeppesen P B Gregersen S Alstrup K K eta!	2002	Phytomedicine2002，9，1：	1
5	The Right Way to Manage Expatriates 显示文摘	Black J S Gregersen H B	1999	Harvard Business Review1999，，：	1
6	Metastasis to the temporal bone may cause acute peripheral vestibular syndrome and impaired hearing 显示文摘	Gregersen KG Hansen S	2013	Ugeskr Laeger2013，175，22：	1
7	Studies on the mechanisms by which gastrin releasing peptide potentiates glucose-induced insulin secretion from mouse islets 显示文摘	Gregersen S Ahr6n B	1996	Pancreas1996，12，1：	1
8	Alcohol and type 2 diabetes 显示文摘	Pietraszek A Gregersen S Hermansen K	2010	Nutr Metah Cardiovasc Dis2010，20，5：	1
9	Glucose desensitization in INS-1 cells: evidence of impaired function caused by glucose metabolite(s) rather than by the glucose molecule per se显示文摘	Brock B Mogensen JH Gregersen S	2002	Metabolism2002，51，6：	1
10	A multimodal laser Doppler and endosonographie distension device for studying meehanosensation and mueosal blood flow in the oesophagus 显示文摘	HOFF DA GREGERSEN H ODEGAARD S	2006	Neurogastroenterol Motil2006，18，：	1
11	OpenMI:Open modelling interface显示文摘	GREGERSEN J B GIJSBERS P L A and WESTEN S LP	2007	Journal ofHydroinformatics2007，9，3：	1
12	Holeboard discrimination learning in mice 显示文摘	KUC K A GREGERSEN B M GANNON K S	2006	Genes Brain Behav2006，5，4：	1
13	Stevioside includes an-tihyper-glycaemic,and glucagonostatic effects in vivo:studies in thediabetic Goto-Kakizaki(GK)rats显示文摘	Jeppesen P B Gregersen S Alstrup K K	2002	Phytomedicine2002，9，1：	1
14	Stevioside induces antihyper - glyeaemic , and glucagonostatic effects in vivo: studies in the diabetic Goto - Kakizaki (GK) rats显示文摘	Jeppesen P B Gregersen S Alstrup K	2002	Phytomedicine2002，，9：	1
15	Antihyperglycemic effects of stevioside in type 2 diabetic subjects显示文摘	Gregersen S Jeppesen PB HolstJJ	2004	Metabolism2004，53，1：	1
16	Toward a theoretical framework of repatriation adjustment显示文摘	Gregersen H B Mendenhall M E	1992	Journal of International Business Studies1992，23，4：	1
17	Language Learning and Perfectionism:Anxious and Non-anxious Language Learners’Reactions to Their Own Oral Performance显示文摘	GREGERSEN T S HORWITS E K	2002	The Modern Language Journal2002，，3：	1
18	Cancer in esophagus and cardia-incidence trends in Denmark显示文摘	Gregersen LH Friis S Olsen JH		0，，：	1
19	Antihyperglycemic ef ects of stevioside in type 2 diabetic subjects显示文摘	Gregersen S Jeppesen P B Holst J J		0，，：	1
20	Association of STAT4 with rheumatoid arthritis in the Korean population显示文摘	Lee H S Remmers E F Le J M Kastner D L Bae S C Gregersen P K	2007	Mol Med2007，13，：	1

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