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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Validity and Reliability of the Reflux Symptom Index (RSI)显示文摘 | Peter C Belafsky Gregory N Postma James A Koufman | 2002 | Journal of Voice2002，，2： | 3 |
| 3 | Cooperative diversity in wireless networks: efficient protocols and outage behavior显示文摘 | Laneman J N Tse D N C Wornell Gregory W | 2004 | IEEE Transactions on Information Theory2004，50，12： | 1 |
| 4 | Rates of Return to Schooling in China显示文摘 | Chow Gregory C Johnson Emily N | | 0，，02： | 1 |
| 5 | Laboratory Plasma Astrophysics Simulation Experiments Using La- sers 显示文摘 | Woolsey N C Gregory C D Kodama R | 2008 | J Phys Conf Ser2008，112，04： | 1 |
| 6 | Holland:Genetic modeling of glioma formation in mice显示文摘 | Martin Begemann Gregory N Eric C | 2002 | Brain Pathol2002，12，1： | 1 |
| 7 | Effects of husbandry system on broken bones and bone strength in hens显示文摘 | Gregory N C Wilkins L J | 1990 | Vet Record1990，128，： | 1 |
| 8 | Neuronal nicotinic acetylcholine receptor expression by O2A/oligodendrocyte progenitor cells显示文摘 | Rogersd S W Gregori N Z Carlson N Gahring L C | 2000 | Glia2000，33，4： | 1 |
| 9 | Differential effects of increased stocking density, mediated by increased flock size, on feather pecking and aggression in laying hens显示文摘 | Nicol C J Gregory N G Knowles T G | 1999 | Applied Animal Behaviour Science1999，65，2： | 1 |
| 10 | The Guidelines forSocial Life Cycle Assessment of Products:Just in Time! 显示文摘 | BENOIT C GREGORY A N VALDIVIA S | 2010 | The International Journal of Life Cycle Assessment2010，15，2： | 1 |
| 11 | Optimizing wheat harvest cutting height for harvest efficiency and soil and water conservation 显示文摘 | Gregory S M Robet M A David C N | 2000 | Agron J2000，，92： | 1 |
| 12 | α2-Heremans-schmid glycoprotein(fetuin A)downregulation and its utility in inflammatory bowel disease显示文摘AIM To investigate the impact of inflammatory bowel disease (IBD) on α2-Heremans-Schmid Glycoprotein(AHSG/fetuin A) and potential associations with disease and patient characteristics.METHODS AHSG serum levels were determined in treatment-na?ve newly-diagnosed patients, 96 with ulcerative colitis(UC), 84 with Crohn's disease (CD), 62 with diarrheapredominant or mixed irritable bowel syndrome (IBS, D- and M- types) and 180 healthy controls (HC), by an enzyme linked immunosorbent assay (ELISA).All patients were followed for a minimum period of 3 years at the Gastroenterology Department of the University Hospital of Larissa, Greece. C-reactive protein(CRP), anti-glycan antibodies, anti-Saccharomyces cerevisiae mannan antibodies Ig G, anti-mannobioside carbohydrate antibodies Ig G, anti-laminariobioside carbohydrate antibodies Ig G and anti-chitobioside carbohydrate antibodies Ig A were also determined via immunonephelometry and ELISA, respectively.RESULTS The mean ± SE of serum AHSG, following adjustment for confounders, was 0.32 ± 0.02 g/L in IBD, 0.32 ± 0.03 g/L in CD and 0.34 ± 0.03 g/L in UC patients, significantly lower than in IBS patients(0.7 ± 0.018 g/L) and HC (0.71 ± 0.02 g/L) (P < 0.0001, in all cases). AHSG levels were comparable between the CD and UC groups. Based on AHSG levels IBD patients could be distinguished from HC with about 90% sensitivity and specificity. Further adjusted analysis verified the inverse association between AHSG and penetrating, as well as stricturing CD (partial correlation coefficient: -0.45 and -0.33, respectively) (P < 0.05). After adjusting for confounding factors, inverse correlations between AHSG and CRP and the need for anti-TNFα therapy or surgery, were found (partial correlation coefficients:-0.31,-0.33,-0.41, respectively, P < 0.05, in all cases). Finally, IBD individuals who were seropositive, for at least one marker, had AHSG levels falling within the two lower quartiles (OR = 2.86, 95%CI: 1.5-5.44, P < 0.001) while those with at least two serological markers positive exhibited AHSG concentrations within the lowest quartile (OR = 5.03, 95%CI: 2.07-12.21, P < 0.001), after adjusting for age, sex and smoking.CONCLUSION AHSG can be used to distinguish between IBD and IBS patients or HC while at the same time 'predicting' complicated disease behavior, need for therapy escalation and surgery. Moreover, AHSG may offer new insights into the pathogenesis of IBD, since it is involved in key processes. | Anastassios C Manolakis Gregory Christodoulidis Andreas N Kapsoritakis Panagiotis Georgoulias Elisavet K Tiaka Kostas Oikonomou Varvara J Spyros P Potamianos | 2017 | World Journal of Gastroenterology2017，23，3： | 1 |
| 13 | Norin10 semi-dwarfism in tetraploid wheat and associated effects on yield显示文摘 | Gale M D Law C N Gregory R S | 1981 | Euthytica1981，30，： | 1 |
| 14 | The Great Britain Historical GIS Project: from Maps to Changing Human Geography显示文摘 | GREGORY I N BENNETT C GILHAM V L | 2002 | Carto- graphic Journal2002，39，： | 1 |
| 15 | A double-negative feedback loop between ZEBl-sipl and the microma- 200 family regulates epithelial-mesenchymal transition 显示文摘 | BRACKEN C P GREGORY P A KOLESNIKOFF N | 2008 | Cancer Res2008，68，19： | 1 |
| 16 | Validity and reliabili- ty of the reflux symptom index (RSI)显示文摘 | Peter C Belafsky PC Gregory N | 2002 | Journal of Voice2002，16，： | 1 |
| 17 | Develop- ment and evMuation of an experimental model of cutaneous columnaris disease in Koi Cyprinus carp/o显示文摘 | Tripathi N K Latimer K S Gregory C R | 2005 | Journal of veteri- nary diagnostic investigation2005，17，1： | 1 |
| 18 | Outbreak of carbapenem- resistant Klebsiella pneumoniae in Puerto Rico associated with a novel carbapenem variant显示文摘 | Gregory C J Llata E Stine N | 2010 | Infect Control Hosp Epidemi- ol2010，31，： | 1 |
| 19 | Tuber regimontanum,new species of truffle from Mexico显示文摘 | GONZALO G GREGORY B EFR(E)N C | 2008 | Revista Mexicana de Micologla2008，26，： | 1 |
| 20 | Abundant larval transcript-1 and -2 genes from Brugia malayi: diversity of genomic environments but conservation of 5' promoter sequences functional in Caenorhabditis elegans 显示文摘 | Gomez-Escobar N Gregory W F Britton C | 2002 | Molecular & Biochemical Parasitology2002，125，： | 1 |
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