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| 1 | Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis显示文摘AIM To evaluate the liver regeneration capacity(LRC) after partial hepatectomy(PH) in experimental non-alcoholic steatohepatitis(NASH).METHODS Fifty-four female rats were fed a high-fat, high-cholesterol diet(HFCD, 65% fat, 1% cholesterol) or standard diet(STD) for 16 wk. A 70% PH was performed and the animals were euthanised before PH or 2 or 5 d postPH. LRC was evaluated using: The total number of Ki-67 positive hepatocytes in the caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, the regenerated protein ratio(RPR), prothrombin-proconvertin ratio(PP), and m RNA expression of genes related to regeneration.RESULTS The HFCD NASH model showed significant steatosis with ballooning and inflammation, while no fibrosis was present. Mortality was similar in HFCD and STD animals following PH. HFCD groups were compared to respective STD groups and HFCD animals had a significantly elevated alanine transaminase at baseline(P < 0.001), as well as a significantly elevated bilirubin at day 2 after PH(P < 0.05). HFCD animals had a higher N(Ki-67, lobe) at baseline,(P < 0.0001), day 2 after PH(P = 0.06) and day 5 after PH(P < 0.025). We found no significant difference in RPR or PP neither 2 or 5 d post-PH. Expression of liver regeneration genes(e.g., hepatic growth factor) was higher at both day 2 and 5 post-PH in HFCD groups(P < 0.05).CONCLUSION NASH rats had a preserved LRC after hepatectomy when compared to STD rats. The methods and models of NASH are essential in understanding and evaluating LRC. | David Haldrup Sara Heeboll Karen Louise Thomsen Kasper Jarlhelt Andersen Michelle Meier Frank Viborg Mortensen Jens Randel Nyengaard Stephen Hamilton-Dutoit Henning Gronbaek | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 2 | The treatment of female bladder neck dysfunction显示文摘 | Gronbaek K Struckmann JR | 1992 | Scand J Urol Nephrol1992，26，2： | 2 |
| 3 | Drinking fre- quency, mediating biomarkers, and risk of myocardial infarction in women and men 显示文摘 | Mukamal K J Jensen M K Gronbaek M | 2005 | Circulation2005，112，10： | 1 |
| 4 | Risk of venous thromboembolism in patients with liver disease:a nationwide population-based case-control study显示文摘 | Sogaard KK Horvath-Puho E Gronbaek H | 2009 | Am J Gastroenterol2009，104，1： | 1 |
| 5 | Alterations of the MMAC1/PTEN gene in lymphoid malignancies 显示文摘 | Gronbaek K Zeuthen J Guldberg P | 1998 | Blood1998，91，11： | 1 |
| 6 | Mutational a nalysis of the tumour suppressor gene MMACI/PTEN in ma lignant myeloid disorders 显示文摘 | Aggerholm A Gronbaek K Guldberg P | 2000 | Eur J Haematol2000，65，2： | 1 |
| 7 | The renal expression of trans forming growth factor-β isoforms and their receptors in acute and chronic experimental diabetes in rats显示文摘 | Hill C Flyvbjerg A Gronbaek H | 2000 | Endocrinology2000，141，3： | 1 |
| 8 | Infrequent somatic Fas mutations but no evidence of Bc11O mutations or t(11:18) in primary cutaneous MALT-type lymphoma显示文摘 | Gronbaek K Ralfkiaer Kalla J | 2003 | J Pathol2003，201，1： | 1 |
| 9 | Advances in DNA methylation: 5-hydroxymethylcytosine revisited 显示文摘 | Dahl C Gronbaek K Guldberg P | 2011 | Clin Chim Acta2011，412，1112： | 1 |
| 10 | Infrequent somatic Fas mutation but no evidence of Bcl10 mutation or t(11;18) in primary cutaneous MALT-type lymphoma显示文摘 | Gronbaek K Ralfkiaer E Kalla J | 2003 | J Pathol2003，201，1： | 1 |
| 11 | Insulin-like growth favtors (IGFs) and IGF binding proteinsin active Crohn’s disease treated with Q-3 or Q-6 fattyacids and corticosteroids 显示文摘 | Eivindson M Gronbaek H Nielsen JN | 2005 | Scand J Gastroenterol2005，40，10： | 1 |
| 12 | Type of alcohol consumed and mortality from all causes, coronary heart diease and cancer 显示文摘 | Gronbaek M Beeher U Joh AD | 2000 | Ann Intern Med2000，133，： | 1 |
| 13 | Drinking frequency,mediating biomarkers,and risk of myocar dial in farction in women and men显示文摘 | Mukamal KJ Jensen MK Gronbaek M | 2005 | Circulation2005，112，： | 1 |
| 14 | Autoimmune phenomena in non-Hodgkin' s lymphoma显示文摘 | Gronbaek K D' Amore F Schmidt K | 1995 | Leuk Lymphoma1995，18，： | 1 |
| 15 | Amount and type of alcohol and risk of dementia:the Copenhagen City Heart Study显示文摘 | TRUELSEN T THUDIUM D GRONBAEK M | 2002 | Neurology2002，59，9： | 1 |
| 16 | Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer显示文摘 | Bartkova J Guldberg P Gronbaek K | 2004 | Oncogene2004，23，52： | 1 |
| 17 | Wine intake and diet in a random sample of 48,763 Danish men and women显示文摘 | TJONNELAND A GRONBAEK M STRIPP C OVERVAD K | 1999 | Am J Clin Nutrition1999，69，1： | 1 |
| 18 | Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men显示文摘 | Mukarnal KJ Jensen MK Gronbaek M | 2005 | Circulation2005，112，10： | 1 |
| 19 | Mortality associated with moderate intakes of wine,beer,or spirits显示文摘 | Deis A Sorensen TI | 1995 | BMJ1995，310，： | 1 |
| 20 | MicroRNAs in mantle cell lymphoma显示文摘 | Husby S Geisler C Gronbaek K | 2013 | Leuk Lymphoma2013，54，9： | 1 |
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