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| 1 | Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis显示文摘AIM To evaluate the liver regeneration capacity(LRC) after partial hepatectomy(PH) in experimental non-alcoholic steatohepatitis(NASH).METHODS Fifty-four female rats were fed a high-fat, high-cholesterol diet(HFCD, 65% fat, 1% cholesterol) or standard diet(STD) for 16 wk. A 70% PH was performed and the animals were euthanised before PH or 2 or 5 d postPH. LRC was evaluated using: The total number of Ki-67 positive hepatocytes in the caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, the regenerated protein ratio(RPR), prothrombin-proconvertin ratio(PP), and m RNA expression of genes related to regeneration.RESULTS The HFCD NASH model showed significant steatosis with ballooning and inflammation, while no fibrosis was present. Mortality was similar in HFCD and STD animals following PH. HFCD groups were compared to respective STD groups and HFCD animals had a significantly elevated alanine transaminase at baseline(P < 0.001), as well as a significantly elevated bilirubin at day 2 after PH(P < 0.05). HFCD animals had a higher N(Ki-67, lobe) at baseline,(P < 0.0001), day 2 after PH(P = 0.06) and day 5 after PH(P < 0.025). We found no significant difference in RPR or PP neither 2 or 5 d post-PH. Expression of liver regeneration genes(e.g., hepatic growth factor) was higher at both day 2 and 5 post-PH in HFCD groups(P < 0.05).CONCLUSION NASH rats had a preserved LRC after hepatectomy when compared to STD rats. The methods and models of NASH are essential in understanding and evaluating LRC. | David Haldrup Sara Heeboll Karen Louise Thomsen Kasper Jarlhelt Andersen Michelle Meier Frank Viborg Mortensen Jens Randel Nyengaard Stephen Hamilton-Dutoit Henning Gronbaek | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 2 | Palliative Care in the Treatment of Advanced Heart Failure显示文摘 | Eric D. Adler Judith Z. Goldfinger Jill Kalman Michelle E. Park Diane E. Meier | 2009 | Circulation2009，，25： | 1 |
| 3 | Using High -Probability Foods to Increase the Acceptance of Low -Probability Foods显示文摘 | Meier Aimee E Fryling Mitch J Wallace Michele D | 2012 | Journal of Applied Behavior Analy- sis2012，，45： | 1 |
| 4 | Improved Response to Cardiac Resynchronization Therapy Through Optimization of Atrioventricular and Interventricular Delays Using Acoustic Cardiography: A Pilot Study显示文摘 | Stefan Toggweiler Michel Zuber Richard Kobza Markus Roos Peiman Jamshidi Rolf Meier Paul Erne | 2007 | Journal of Cardiac Failure2007，，8： | 1 |
| 5 | Increased growth hormone (GH), growth hormone receptor (GHR), and insulin-like growth factor I (IGF-I) gene transcription after hyperosmotic stress in the Brazilian flounder Paralichthys orbignyanus显示文摘 | Karina M. Meier Márcio A. Figueiredo Michel T. Kamimura Jomar Laurino Rodrigo Maggioni Luciano S. Pinto Odir A. Dellagostin Marcelo B. Tesser Luís A. Sampaio Luis F. Marins | 2009 | Fish Physiology and Biochemistry2009，，3： | 1 |
| 6 | Correlation of Intravascular Ultrasound Findings With Histopathological Analysis of Thrombus Aspirates in Patients With Very Late Drug-Eluting Stent Thrombosis显示文摘 | Stéphane Cook Elena Ladich Gaku Nakazawa Parham Eshtehardi Michel Neidhart Rolf Vogel Mario Togni Peter Wenaweser Michael Billinger Christian Seiler Steffen Gay Bernhard Meier Werner J. Pichler Peter Jüni Renu Virmani Stephan Windecker | 2009 | Circulation2009，，： | 1 |
| 7 | Increased growth hormone (GH), growth hormone receptor (GHR), and insulin-like growth factor I (IGF-I) gene transcription after hyperosmotic stress in the Brazilian flounder Paralichthys orbignyanus显示文摘 | Karina M. Meier Márcio A. Figueiredo Michel T. Kamimura Jomar Laurino Rodrigo Maggioni Luciano S. Pinto Odir A. Dellagostin Marcelo B. Tesser Luís A. Sampaio Luis F. Marins | 2009 | Fish Physiology and Biochemistry2009，，3： | 1 |
| 8 | Validation of a surgical model for posthepatectomy liver failure in rats显示文摘Background:The upper limit for liver resections in rats is approximately 90%.In the early postoperative phase,mortality increases.The aim of the present study was to validate the rat model of 90%partial hepatectomy(PH)as a model of post-hepatectomy liver failure(PHLF).Further,we wanted to test a quantitative scoring system as a detector of lethal outcomes caused by PHLF in rats.Methods:Sixty-eight rats were randomized to 90%PH,sham operation,or no sur-gery.Further,block randomization was performed based on time of euthanization:12,24,or 48 h after surgery.A general distress score(GDS)≥10 during the day or≥6 at midnight prompted early euthanization and classification as nonsurvivor.Animals euthanized as planned were classified as survivors.During euthanization,blood and liver tissue were collected,and liver-specific biochemistry was evaluated.Results:Based on the biochemical results,all animals subjected to 90%PH expe-rienced PHLF.Seventeen rats were euthanized due to irreversible PHLF.The GDS increased for nonsurvivors within 12–18 h after surgery.The mean time for euthaniza-tion was 27 h after surgery.Conclusion:Based on the GDS and liver-specific biochemistry,we concluded that the model of 90%PH seems to be a proper model for investigating PHLF in rats.As a high GDS is associated with increased mortality,the GDS appears to be valuable in detect-ing lethal outcomes caused by PHLF in rats. | Andrea Lund Michelle Meier Kasper Jarlhelt Andersen Marie Ingemann Pedersen Anders Riegels Knudsen Jakob Kirkegård Frank Viborg Mortensen | 2023 | Animal Models and Experimental Medicine2023，6，3： | 0 |
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