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| 1 | PD-L1在不同乳腺癌亚型及分期病例中的表达及其肿瘤内异质性:245例原发和40例转移癌的研究显示文摘肿瘤组织中PD—L1表达与多种恶性肿瘤免疫逃逸有关,包括三阴型乳腺癌,通过PD—L1标记有助于选择适合于PD—I/PD—L1抑制剂治疗患者。作者采用组织芯片技术对各种组织学形态的乳腺癌进行PD—L1表达和研究,以探讨其在原发和转移性乳腺癌中的异质性,研究病例包括245例原发性乳腺癌和40例转移性乳腺癌(淋巴结转移及远处转移各20例),瘤细胞PD—L1膜着色细胞≥1%定义为阳性。 | Dill E A Gru A A Atkins K A.Atkins 王婷 余英豪 | 2017 | 临床与实验病理学杂志2017，33，10： | 17 |
| 2 | 青光眼患者血清抗视网膜抗原的抗体轮廓质谱分析显示文摘目的比较原发性开角型青光眼(POAG)患者与正常对照(CTRL)者间的抗体轮廓差异。方法病例对照研究。将44例POAG患者与48例CTRL者的血清分别加入到含有预洗Dyna珠-G蛋白的反应管中,以捕获人免疫球蛋白G(IgG)抗体,形成的IgG—G蛋白复合体用来捕获目标抗原(匀质化牛视网膜组织)。经洗提后获得的抗原蛋白通过“表面增强激光解吸附-电离-飞行时间-质谱”仪进行检测。采用Proteomic software project统计学软件,对两组质谱数据连同受检者年龄和性别等参数,自动进行t检验和初步多变量判别分析;随后采用Statistica version8.0统计学软件,进行包括抗原蛋白质谱数据、蛋白质芯片类型和激光解吸附-电离能量等的多变量判别分析。结果CTRL组的平均质谱强度为4244.427±4721.115,POAG组为4049.864±4083.819,两组间差异有统计学意义(F=1.340,P〈0.01);在POAG患者中,出现了部分高调节免疫反应,但主要表现为低调节免疫反应。结论在POAG患者与CTRL者之间存在明显的抗体轮廓差异,在POAG组中出现的低调节免疫反应表明部分患者可能与“异常免疫”有关。 | 严良 Joachim S. C Pfeiffer N Grus F.H Erb C | 2009 | 中华眼科杂志2009，45，7： | 3 |
| 3 | Proteome alterations in aqueous humour of primary open angle glaucoma patients显示文摘AIM: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).METHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy for POAG(n=23, age: 72.5±8.3 y) were included. AH samples of those patients were obtained during cataract surgery or trabeculectomy. AH samples were subsequently pooled into the experimental groups under equal contribution in terms of protein amount of each individual patient. Protein samples were analyzed by a linear trap quadrupol Orbitrap Mass Spectrometry device with an upstream liquid chromatography system. The obtained raw data were analyzed using the Maxquant proteome software and compared. Proteins with a fold-change ratio higher than a cut-off of 2 were considered as noticeably altered.RESULTS: A total number of 175 proteins could be identified out of the AH from POAG and cataract by means of quantitative mass spectrometric analysis. Apolipoprotein D(fold change, 3.16 times), complement C3(2.96), pigment epithelium-derived factor(2.86), dickkopf-related protein 3(2.18) and wingless-related integration(Wnt) inhibitory factor 1(2.35) were significantly upregulated within the AH of glaucoma compared to cataract serving as controls.CONCLUSION: AH provides a tool to analyze changes in glaucoma and shows striking changes in Wnt signaling inhibitory molecules and other proteins. | Hanhan Liu Fabian Anders Sebastian Funke Karl Mercieca Franz Grus Verena Prokosch | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 2 |
| 4 | Striatal antibodies in children with Tourette's syndrome: multivariate discriminant analysis of IgG repertoires显示文摘 | Wendlandt JT Grus FH Hansen BH | 2001 | J Neuroimmunol2001，119，1： | 1 |
| 5 | Morbidity asso ciatedwith ORIF of intraarticular calcaneus fraetures using a lateral approach显示文摘 | Harvey EJ Gru]ic L Early JS | 2001 | Foot Ankle Int2001，22，1： | 1 |
| 6 | Autologous fat transfer-induced facial nodule显示文摘 | Brodell L A Gru A A Haughey B | 2013 | J Am Acad Dermatol2013，69，2： | 1 |
| 7 | SELDI- TOF- MS proteinchip array profiling of tears from patients with dry eye 显示文摘 | Grus FH Podust VN Bruns K | 2005 | Invest Ophthalmol Vis Sci2005，46，3： | 1 |
| 8 | Changes in the tear proteins of diabetic patients显示文摘 | Grus F H Sabuncuo P Dick H B | 2002 | BMC Ophthalmol2002，2，1： | 1 |
| 9 | A daptive Least Squares Correlation A Powerful Image Matching Technique显示文摘 | GRU EN A | 1985 | South African Journal of Photogrammetry Remote Sensing and Cartography1985，14，3： | 1 |
| 10 | Bedeutung der TSH-Rezeptor-Antik?rper für die Diagnose des Morbus Basedow sowie die Prognoseabsch?tzung der Schilddrüsenüberfunktion und der endokrinen Orbitopathie显示文摘 | Anja Eckstein Klaus Mann George J. Kahaly Martin Gru?endorf Christoph Reiners Joachim Feldkamp Beate Quadbeck Andreas Bockisch Prof. Dr. Matthias Schott | 2009 | Medizinische Klinik2009，，5： | 1 |
| 11 | Model selection based on minimum description length 显示文摘 | Gru nwald P | 2000 | Journal of Mathematical Psychology2000，44，1： | 1 |
| 12 | Road Extraction from Aerial and Satellite Images by Dynamic Programming显示文摘 | GRU EN A L I H | 1995 | ISPRS Journal of Photogrammetry and Remote Sensing1995，50，4： | 1 |
| 13 | Analysis of tear protein patterns by a neural network as a diagnostical tool for the detection of dry eyes显示文摘 | Grus FH Augustin AJ | 1999 | Electrophoresis1999，20，45： | 1 |
| 14 | Three-to 7 years results with the uncemented SL femoral revision prosthesis显示文摘 | Gruing R Morscher E Ochsner PE | 1996 | Arch Orthop Trauma Surg1996，116，： | 1 |
| 15 | Comparison of dynamic contour tonometry and goldmann applanation tonometry in glaucoma patients and healthy subjects显示文摘 | Barleon L Hoffmann EM Berres M Pfeiffer N Grus FH | 2006 | Am J Ophthalmol2006，142，： | 1 |
| 16 | Changes in the tear protein patterns of diabetic patients using two-dimensional electrophoresis显示文摘 | Herber S Grus FH Sabuncuo P Augustin AJ | 2002 | Adv Exp Med Biol2002，505，： | 1 |
| 17 | Multinational production, absorptive capacity and endogenous R&D spillovers 显示文摘 | Gru nfeld L A | 2006 | Review of international economics2006，14，5： | 1 |
| 18 | Effect of smoking on tear proteins 显示文摘 | Grus FH Sanuncuo P Augustin A Pfeiffer N | 2002 | Graefes Arch Clin Exp Ophthalmol2002，240，11： | 1 |
| 19 | Neonatal screening for congenital adrenal hyperplasia:experience and results in Argentina显示文摘 | Gru(n)ieiro-Papendieck L Chiesa A Mendez V | 2008 | J Pediatr Endocrinol Metab2008，21，1： | 1 |
| 20 | Photocatalytic Degradation of Organic Pollutants at Solution Bulk with Pigment/TiO<sub>2</sub> Nanocomposite显示文摘 | Xin Shu Wen Zhong Lou Yue Zhao Min Gru Guo Yue Fu Ying Wang | 2013 | Key Engineering Materials2013，，562： | 1 |
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