|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current state of surgical treatment of liver metastases from colorectal cancer显示文摘Hepatic resection is the procedure of choice for curative treatment of colorectal liver metastases(CLM).Objectives of surgical strategy are low intraoperative blood loss,short liver ischemic times and minor postoperative morbidity and mortality.Blood loss is an independent predictor of mortality and compromises,in common with postoperative complications,long-term outcome after hepatectomy for CLM.The type of liver resection has no impact on the outcome of patients with CLM;wedge resections are not inferior to anatomical resections in terms of tumor clearance,pattern of recurrence or survival.Despite the lack of proof of survival benef it,routine lymphadenectomy has been advocated,allowing the detection of microscopic lymph node metastases and with prognostic value.In experienced hands,minimally invasive liver surgery is safe with acceptable morbidity and mortality and oncological results comparable to open hepatic surgery,but with reduced blood loss and earlier recovery.The European Colorectal Metastases Treatment Group recommended treating up front with chemotherapy for patients with both resectable and unresectable CLM.However,neoadjuvant chemotherapy can induce damage to the remnant liver,dependent on the number of chemotherapy cycles.Therefore,in our opinion,preoperative chemotherapy should be reserved for patients whose CLM are marginally resectable or unresectable.A meta analysis of randomized trials dealing with perioperative chemotherapy for the treatment of resectable CLM demonstrated a benefit of systemic chemotherapy but did not answer the question of whether a neoadjuvant or adjuvant approach should be preferred.Analysis of the literature demonstrates that the results of specialized centers cannot be attained in the reality of comprehensive patient care.Reasons behind the commonly poorer results seen in cancer networks as compared with literature-based data are,on the one hand,geographical disparities in access to specialized surgical and medical care.On the other hand,a selection bias in the reports of the literature may be assumed.Studies of surgical resection for CLM derive almost exclusively from case series generally drawn from large academic centers where patient selection or surgical expertise is superior to what is found in many communities.Therefore,we may conclude that the comprehensive propagation of the standards outlined in this paper constitutes a major task in the near future to reduce the variations in survival of patients with CLM. | Reinhart T Grundmann | 2011 | World Journal of Gastrointestinal Surgery2011，3，12： | 8 |
| 2 | Primary colon resection or Hartmann's procedure in malignant left-sided large bowel obstruction? The use of stents as a bridge to surgery显示文摘There is still significant debate regarding the best surgical treatment for malignant left-sided large bowel obstruction.Primary resection and anastomosis offers the advantages of a definite procedure without need for further surgery.Its main disadvantages are related to the increased technical challenge and to the potential higher risk of anastomotic leakage that occurs in the emergency setting.Primary resection with end colostomy(Hartmann's procedure) is considered the safer option.Tan et al compared in a systematic review and meta-analysis the use of self-expanding metallic stents(SEMS) as a bridge to surgery vs emergency surgery in the management of acute malignant left-sided large bowel obstruction.The authors concluded that the technical and clinical success rates for stenting were lower than expected.SEMS was associated with a high incidence of clinical and silent perforation.Stenting instead of loop colostomy can be recommended only if the appropriate expertise is available in the hospital.The goal of stenting,a decrease of the stoma rate,may be advocated only if the complication rates of stenting are lower than those of stoma creation in the emergency situation.Until now,this was not demonstrated in a prospective randomized trial. | Reinhart T Grundmann | 2013 | World Journal of Gastrointestinal Surgery2013，5，1： | 5 |
| 3 | MicroRNA-100 regulates neovascularization by suppres- sion of mammalian target of rapamycin in endothelial and vas- cular smooth muscle cells 显示文摘 | Grundmann S Hans FP Kirmiry S Heinke J Helbing T Blubm F et 02 | 2011 | Circulation2011，123，9： | 1 |
| 4 | Effect of sodium on material and device quality in low temperature deposited Cu(In,Ga)Se 2显示文摘 | S. Puttnins S. Levcenco K. Schwarzburg G. Benndorf F. Daume A. Rahm A. Braun M. Grundmann T Unold | 2013 | Solar Energy Materials and Solar Cells2013，，： | 1 |
| 5 | Trentment of Associated polyposis(ASSAP)with a cysteiny 1 leukotrene receptor antagonist a prospective drug study on antiinflammatory effect显示文摘 | Grundmann T Topfner M | 2001 | Laryngorhinootologie2001，80，10： | 1 |
| 6 | The value of hyperbaric oxygen therapy(HBO) in treatment of problem wounds in the area of plastic-reconstructive head and neck surgery 显示文摘 | GRUNDMANN T JAEHNE M FRITZE G | 2000 | Laryngorhinootologie2000，79，： | 1 |
| 7 | Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat显示文摘 | Knittel T Mehde M Grundmann A | 2000 | Histochem Cell Biol2000，113，6： | 1 |
| 8 | Treatment of ASS-associated polyposis (ASSAP) with a cysteinyl leukotriene receptor antagonist: a prospective drug study on its anti-inflammatory effects 显示文摘 | Grundmann T Topfner M | 2001 | Laryngorhi- noctologie2001，80，10： | 1 |
| 9 | Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat显示文摘 | Knittel T Mehde M Grundmann A | 2000 | Histochem Cell Biol2000，113，6： | 1 |
| 10 | 查看详情显示文摘 | Bundesmann C Ashkenov N Shubert M Spemann D Butz T Kaida- shev E M Lorenz M Grundmann M | | 0，，： | 1 |
| 11 | Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rats显示文摘 | Knittel T Mehde M Grundmann A | 2000 | Histochem Cell Biol2000，113，6： | 1 |
| 12 | Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat显示文摘 | Knittel T Mehde M Grundmann A | 2000 | Histochem Cell Biol2000，113，6： | 1 |
| 13 | Complete cDNA sequence encoding human (-galactoside alpha 2, 6-sialyltransferase显示文摘 | Grundmann U Nehrlich C Rein T | 1990 | Nucleic Acids Res1990，18，3： | 1 |
| 14 | A framework for global surveillance of antibiotic resistance 显示文摘 | Grundmann H Klugman K P Walsh T | 2011 | Drug Resistance Updates2011，14，2： | 1 |
| 15 | MicroRNA-100 regulates neovascularization by suppression of mammalian target of rapamycin in endothelial and vascular smooth muscle cells 显示文摘 | Grundmann S Hans FP Kinniry S Heinke J Helbing T Blulun F et at | 2011 | Circulation2011，123，9： | 1 |
| 16 | Expression of matrix metalloproteinases and their inhihitors during hepatic tissue re- pair in the rat显示文摘 | Knittel T Mehde M Grundmann A | 2000 | Histochem Cell Biol2000，113，： | 1 |
| 17 | The reconstruction of auricular defects-operative systematics and first experiences for the use of a combined skinflap显示文摘 | Grundmann T | 2000 | HNO2000，48，2： | 1 |
| 18 | A frame- work for global surveillance of antibiotic resistance 显示文摘 | Grundmann H Klugman KP Walsh T etal | 2011 | Drug Resist Updat2011，14，2： | 1 |
| 19 | Low-order optical whispering gallery mode in hexagonal nanocavities 显示文摘 | T Nobis M Grundmann | 2005 | Phys Rev A2005，72，06： | 1 |
| 20 | FtmPT2, an N- prenyltransferase from AspergiUus fumigatus, catalyses the last step in the biosynthesis of furaitremorgin B显示文摘 | Grundmann A Kuznetsova T Afiyatullov S S | 2008 | Chembiochem2008，9，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员