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| 1 | Development of a procedure for estimating the parameters of mechanistic VOC emission source models from chamber testing data显示文摘In order to evaluate the impacts of volatile organic compounds(VOCs)emissions from building materials on the indoor air quality beyond the standard chamber test conditions and test period,mechanistic emission source models have been developed in the past.However,very limited data are available for the required model parameters including the initial concentration(C_(m0)),in-material diffusion coefficient(D_(m)),partition coefficient(Kma),and convective mass transfer coefficient(k_(m)).In this study,a procedure was developed for estimating the model parameters by using VOC emission data from standard small chamber tests.In the procedure,initial values of the model parameters were refined by multivariate regression analysis of the measured emission data.To verify the procedure and estimate its uncertainty,simulated chamber test data were generated by adding 10% experimental uncertainties on the theoretical curve from the analytical solution to a mechanistic emission model.Then the procedure was applied to the generated data to estimate the model parameters.Results indicated that estimates converged to the original parameter values used for the data generation and the error of estimated parameters D_(m1)C_(m0) and K_(ma) were within±10%,±23%,and±25%of the true values,respectively.The procedure was further demonstrated by applying it to estimate the model parameters from real chamber test data.Wide application of the procedure would result in a database of mechanistic source model parameters for assessing the impact of VOC emissions on indoor pollution load,which are essential input data for evaluating the effectiveness of various indoor air quality(IAQ)design and control strategies as well as the energy required for meeting given IAQ requirements. | Zhenlei Liu Andreas Nicolai Marc Abadie Menghao Qin John Grunewald Jianshun Zhang | 2021 | Building Simulation2021，14，2： | 4 |
| 2 | Mountain Water Tower and Ecological Risk Estimation of the Mesta-Nestos Transboundary River Basin (Bulgaria-Greece)显示文摘The Mesta-Nestos river basin in Bulgaria and Greece is a case study for transboundary decision-making support in south-eastern Europe and a show-case for the development of methodologies and information-gathering for the integrated regional planning of water resources. Land-use conflicts in this water-scarce region cover a wide spectrum of activities like agricultural irrigation,drinking water production,diversions for industrial water,and risk of pollution from mining,to name a few examples. Measurements of the water quality were carried out in the upper basin. Results will be illustrated by the example of the environmental situation in the alpine region of the Pirin National Park as well as in the Razlog Basin with a stronger anthropogenic impact and pollution around a former uranium mine near the village of Ele?nica. The social and economic development of this transboundary region is a recently established priority for the future. It will mean an increase in water usage and more stress for the water resources if regional impacts of global climate change are verified. Problem-focused management of the catchment area as a whole on the basis of proved geo-data sets is needed for the future. | K. Grunewald J. Scheithauer J.-M. Monget N. Nikolova | 2007 | Journal of Mountain Science2007，4，3： | 2 |
| 3 | Induction of ultra-morphological features of apoptosis in mature and immature sperm显示文摘有建议激活的 apoptosis 在呼喊的人的精子发信号否定地影响他们的授精潜力的证据的基本身体。然而,发信号的这 apoptotic 是否是与精子发生有关的未成功的 apoptosis 的一件遗物,仍然是争论的或如果它应该在导致 stereotypical 的成熟精子被认为是一条功能的 preformed 小径词法变化思考原子拆卸。探讨这个问题, apoptosis 在密度坡度 centrifugation 充实的成熟、不成熟的呼喊的人的精子用 betulinic 酸被导致。apoptosis 的执行被经由传播电子显微镜学观察极端词法的变化监视。在体的房间的 apoptosis 的典型词法符号与 apoptotic 身体,损害 mitochondrial 正直,原子信封的缺点,和原子破碎的形成包括血浆膜 blebbing;这些形态学也在人的精子被观察了。另外,这些 apoptotic 特征在与成熟精子相比的不成熟的精子是更经常的。后面的 betulinic 酸处理, apoptosis 相关的词法变化从健康施主在成熟精子被导致。这效果更不在不成熟的精子被读。而且在两部分, betulinic 酸处理增加了反应 acrosome 的精子的百分比。我们的极端词法的学习的结果在成熟呼喊的人的精子证明 apoptosis 的功能的胜任。一个唯一的未成功的过程的理论可能为不成熟的精子仅仅是有效的。由刺激 apoptosis 的 acrosome 反应的正式就职可能使精子 apoptosis 的生物关联清楚些。 | Sonja Grunewald Guenther Fitzl Christopher Springsguth | 2017 | Asian Journal of Andrology2017，19，5： | 2 |
| 4 | Immunomagnetic removal of cryo-damaged human spermatozoa显示文摘Aim: To estimate the dissipation of mitochondrial transmembrane potential (mTMP, △ψm) and activation of sperm caspases (aCP) as signs of apoptosis in human spermatozoa during cryopreservation and to evaluate the efficiency of immunomagnetic cell separation (MACS) of these spermatozoa via annexin V-binding. Methods: The mTMP and aCP in fresh and cryopreserved spermatozoa were detected by fluorescence microscopy and by Western blots. The sperm suspensions were divided into two sperm fractions (with intact and deteriorated membranes) by magnetic cell separation (MiniMACS, Miltenyi Biotec, Bergisch Gladbach, Germany) in dependence on their binding to superparamagnetic annexin V-microbeads (AN-MB). Results: The cryopreservation decreased the portion of spermatozoa with intact mTMP from 80.1% ± 7.2 % to 53.5 % ± 13.1% and increased the spermatozoa with activated pancaspases (aCP) from 21.8 % ± 2.6 % to 47.7 % ± 5.8 % (n = 10; mean ± SEM; P < 0.01). The activation of caspases 1, 3, 8, and 9 in the cryopreserved spermatozoa was confirmed by Western blots (n = 22). MACS reduced significantly the percentage of cryopreserved spermatozoa with dissipated mTMP to 8.1 ± 3.9 (P < 0.01) and also those with aCP to 9.3 % ± 2.2 %. Western blot analyses confirmed the increase of the activated caspase3, 9, and 8 in the AN-MB-positive fraction (P < 0.05) compared with the AN-MB-negative fraction. The MACS separation effect was confirmed by anti-annexin V-antibodies. There was no significant influence of the separation column and the magnetic field on the sperm functions. Conclusion: The cryopreservation impaired the mTMP and enhanced the activation status of caspases in human spermatozoa. The immunomagnetic sperm separation via binding of AN-MB could deplete low quality spermatozoa from cryopreserved semen samples. | Uwe Paasch Sonja Grunewald Katja Wuendrich Tbrsten Jope Hans-Jurgen Glander | 2005 | Asian Journal of Andrology2005，7，1： | 2 |
| 5 | Role of hetero- mer formation in GABAB receptor function 显示文摘 | Kuner R Kohr G Grunewald S | 1999 | Sci- ence1999，283，： | 1 |
| 6 | Cell shape changes during gastrilation in Drosophila显示文摘 | Leptin M Grunewald B | 1990 | Development1990，110，1： | 1 |
| 7 | Molecular glass wool filtration as a new tool for sperm preparation 显示文摘 | Grunewald S Miska W Miska G | 2007 | Hum Reprod2007，22，5： | 1 |
| 8 | Tourism and cultural revival显示文摘 | Grunewald R | 2002 | Annals of Tourism Research2002，29，4： | 1 |
| 9 | Effect of cultivation parameters on growth and pigment biosynthesis in flafellated cells of Haematococcus pluvialis显示文摘 | Grunewald K Xylander M | 2001 | J Appl Phycol2001，13，： | 1 |
| 10 | CASE : a frame- work for computer supported outbreak detection显示文摘 | Cakici B Hebing K Grunewald M | 2010 | BMC Med Inform Decis Mak2010，10，1： | 1 |
| 11 | Optimized and standardized isolation and structural characterization of anti-inflammatory sulfated polysaccharides from the red alga Delesseria sanguinea (Hudson) Lamouroux (Ceramiales, Delesseriaceae) 显示文摘 | Grunewald N Alban S | 2009 | Biomacromolecules2009，10，11： | 1 |
| 12 | Diffusion tensor imaging in the diagnosis of lateral sclerosis 显示文摘 | Ulug AM Grunewald T 1in Lin MT | 2004 | J Magn Reson Imaging2004，19，1： | 1 |
| 13 | Tourism and cultural revival 显示文摘 | Grunewald R A | 2002 | Annals of Tourism Research2002，29，4： | 1 |
| 14 | Review: role of genetics in susceptibility and outcome of sarcoidosis显示文摘 | Grunewald J | 2010 | Semin Respir Crit Care Med2010，31，4： | 1 |
| 15 | Saturation of 2' ,2' -difluorodeoxycytidine 5' -triphosphate accumulation by mononuclear cells during a phase Ⅰ trial of gemcitabine 显示文摘 | Grunewald R Abbruzzese JL TarassoffP | 1991 | Cancer Chemother Pharmacol1991，27，： | 1 |
| 16 | Pharmacologically directed design of the dose rate and schedule of 2' ,2' - difluorodeoxycitidine (gemcitabine) administration in leukemia 显示文摘 | Grunewald R Kantarjian H Keating M | 1990 | Cancer Res1990，50，： | 1 |
| 17 | Activation pattern of caspases in human spermatozoa显示文摘 | PAASCH U GRUNEWALD S AGARWAL A | 2004 | Fertility and Sterility2004，81，1： | 1 |
| 18 | Paradoxical hyperfibrinolysis is associated with a more intensely haemorrhagic phenotype in severe congenital haemophilia显示文摘 | Grunewald M Siegemund A Grunewald A | 2002 | Haemophilia2002，8，6： | 1 |
| 19 | Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial显示文摘 | Ralf-Dieter Hofheinz Frederik Wenz Stefan Post Axel Matzdorff Stephan Laechelt J?rg T Hartmann Lothar Müller Hartmut Link Markus Moehler Erika Kettner Elisabeth Fritz Udo Hieber Hans Walter Lindemann Martina Grunewald Stephan Kremers Christian Constantin | 2012 | Lancet Oncology2012，，6： | 1 |
| 20 | A probabilistic-based method to evaluate hygrothermal performance of an internally insulated brick wall显示文摘Uncertainty exists in many aspects of building simulation.A deterministic hygrothermal analysis may not sufficiently give a reliable guidance if a number of input variables are subject to uncertainty.In this paper,a probabilistic-based method was developed to evaluate the hygrothermal performance of building components.The approach accounts for the uncertainties from model inputs and propagates them to the outputs through the simulation model,thus it provides a likelihood of performance risk.Latin hypercube sampling technique,incorporated with correlation structure among the inputs,was applied to generate the random samples that follows the intrinsic relations.The performance of an internally insulated masonry wall was evaluated by applying the proposed approach against different criteria.Thermal performance,condensation and mould growth potential of the renovated wall can overall satisfy the requirements stipulated in multifold standards.The most influential inputs were identified by the standardized regression sensitivity analysis and partial correlation technique.Both methods deliver the same key parameters for the single and time-dependent output variables in the case study.The probabilistic method can provide a comprehensive risk analysis and support the decision-maker and engineer in the design and optimization of building components. | Jianhua Zhao Jianshun Zhang John Grunewald Shuo Feng | 2021 | Building Simulation2021，14，2： | 1 |
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