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62篇 您的检索式:作者名="Grzelak"
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1Preoperative high level of D-dimers predicts unresectability of pancreatic head cancer显示文摘AIM: To assess the value of D-dimer level in determining resectability of pancreatic cancer. METHODS: Preoperative prediction of pancreatic head cancer resectability remains inaccurate. The use of hemostatic factors may be of potential help, since D-dimers correlate with tumor stage. Single center clinical trial study comprised patients with potentially resectable pancreatic head tumor and without detectable venous thrombosis(n = 64). Resectability was defined as no evidence of nodal involvement, distant spread and no invasion of mesenteric vessels. Final decision of resectability was confirmed intraoperatively. Experienced pancreatic surgeon performed all surgeries. Following the dissection of hepatoduodenal ligament, samples of portal blood and bile were taken. Peripheral blood via central line and urine via Foley catheter were sampled. D-dimer levels were further measured.RESULTS: At laparotomy only 29(45.3%) tumors were found to be resectable. Our analysis showed higher by 57.5%(P < 0.001) mean D-dimer values in peripheral and 43.7%(P = 0.035) in portal blood of patients with unresectable pancreatic cancer. Significant differences were not observed when analyzing D-dimer levels in bile and urine. Peripheral D-dimer level correlated with pancreatic cancer resectability. When cut-off D-dimer value of 570.6 μg/L was used, the sensitivity for assessment of tumor unresectability was 82.8%. Furthermore, D-dimer level in peripheral blood of metastatic disease(n = 15) was significantly higher when compared to locally advanced(n = 20) pancreatic cancer(2470 vs 1168, P = 0.029). The area under ROC curve for this subgroup of patients was 0.87; for determination of unresectable disease when threshold of 769.8 μg/L was used, sensitivity and specificity was 86.6% and 80%, respectively.CONCLUSION: Patients with resectable pancreatic head cancer based on preoperative imaging studies and high D-dimer level may be considered unresectable due to occult hepatic metastases. These patients may benefit from diagnostic laparoscopy to avoid exploratory laparotomy.Adam Durczynski Anna Kumor Piotr Hogendorf Dariusz Szymanski Piotr Grzelak Janusz Strzelczyk 2014World Journal of Gastroenterology2014,20,36:9
2Time-interval measuring module with short dead-time 显示文摘Zielifiski M Chbaerski D Grzelak S 2003Metrology and Measurements Systems2003,,3:1
3Quechers methodologies as an alternative to solid phase extraction(SPE)for the determination and characterization of residues of cephalosporins in beef muscle using LC-MS/MS显示文摘PREZ-BURGOS R Grzelak E M Gokce G 2012J Chromatogr B Analyt Technol Biomed Life Sci2012,899,12:1
4Benefits and risks associated with genetically modified food products显示文摘Kramkowska M Grzelak T Czyzewska K 2013Ann Agric Environ Med2013,20,3:1
5Composition and properties of chicory extracts rich in fructans and polyphenols显示文摘Milala J Grzelak K Krol B 2009Polish Journal of Food and Nutrition Sciences2009,59,1:1
6Serum osteopro- tegerin is a predictor of progression of atherosclerosis and coronary calcification in hemodialysis patients 显示文摘Kuroatowska I Grzelak P Kaczmarska M 2011Nephron Clin Pract2011,117,4:1
7Control of expression of silk protein genes显示文摘Grzelak K 1995Comparative Biochemistry and Physiology(Part B:Bio- chemistry & Molecular Biology)1995,110,4:1
8Brain metabolism alterations in patients with anorexia nervosa observed in 1H-MRS显示文摘Grzelak P Gajewicz W Wyszogrodzka-Kucharska A 2005Psychiatr Pol2005,39,4:1
9Bioautography detection in thin - layer chromatography 显示文摘Choma IM Grzelak EM 2011Journal of Chromatography2011,1218,19:1
10Perfusion of kidney graft pyramids and cortex in contrast enhanced ultrasonography in the determination of the cause of delayed graft function 显示文摘Grzelak P Szymczyk K Strzelczyk J 2011Ann Transplant2011,23,:1
11Perfusion Disturbances of Kidney Graft Parenchyma Evaluated with Contrast-Enhanced Ultrasonography in the Immediate Period following Kidney Transplantation显示文摘Grzelak P Kurnatowska I Nowicki M etal 2013Nephron Clin Pract2013,124,34:1
12Risk factors for Anterior Cruciate Ligament injury in skeletal y immature patients:analysis of intercondylar notch width using Magnetic Resonance Imaging显示文摘Domzalski M Grzelak P Gabos P 0,,05:1
13Rare infraglottic lesions in magnetic resonance imaging显示文摘BLASIAK-KOLACINSKA N PIETRUSZEWSKA W GRZELAK P 2014Pol J Radiol2014,79,:1
14Disturbances of kidney graft perfusion as indicators of acute renal vein thrombosis in contrast-enhanced ultrasonography 显示文摘Grzelak P Kurnatowska I Sapieha M 2011Transplant Proc2011,43,8:1
15Bone mar- row stem cells and the liver:are they relevant? 显示文摘Eckersley-Maslin M A Warner F J Grzelak C A 2009Gastroenterol Hepatol2009,24,10:1
16Brain metabolism alterations in patients with anorexia nervo- sa observed in 1 H-MRS 显示文摘Grzelak P Gajewicz W Wyszogrodzka-Kucharska A 2005Psychiatr Po2005,39,4:1
17MRI evaluation of the de- velopment of intercondylar notch width in children 显示文摘Domzalski ME Keller MS Grzelak P 2015Surg Radiol Anat2015,37,6:1
18Risk factors for anterior cruciate ligament injury in skeletally immature patients: analysis of intercon- dylar notch width using magnetic resonance Imaging显示文摘Domzalski M Grzelak P Gabos P 2010Int Orthop2010,34,5:1
19Risk factors for anterior cruciate ligament injury in skeletally immature patients: analysis of intercondylar notch width using Magnetic Resonance Imaging显示文摘Domzalski M Grzelak P Gabos P 2010Int Ort hop2010,34,5:1
20Risk factors for Anterior Cruciate Ligament injury in skeletally immature patient:analysis of intercondylar notch width using Magnetic Resonance Imaging显示文摘Domzalsk M Grzelak P Gabos P 2010Int Orthop2010,34,5:1
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